2024
Clinicopathologic features and prognosis of steatohepatitic hepatocellular carcinoma based on varying cutoffs of tumoral steatohepatitic changes
Zhang T, Niu N, Taddei T, Jain D, Zhang X. Clinicopathologic features and prognosis of steatohepatitic hepatocellular carcinoma based on varying cutoffs of tumoral steatohepatitic changes. American Journal Of Clinical Pathology 2024, aqae136. PMID: 39418121, DOI: 10.1093/ajcp/aqae136.Peer-Reviewed Original ResearchSH-HCCSteatohepatitic hepatocellular carcinomaHepatocellular carcinomaLiver diseaseHepatitis C virus infectionC virus infectionStage of fibrosisPresence of steatohepatitisOverall survivalHistological subtypesPrognostic factorsHCC subtypesBackground liverHCC casesClinicopathological featuresConventional HCCHistopathological patternsHyaline globulesTumor cellsMallory-Denk bodiesGlycogenated nucleiSteatotic liver diseaseHCCSurvival analysisSteatohepatitis
2023
Clinicopathologic characterization of hepatocellular adenomas in men: a multicenter experience
González I, Torbenson M, Sharifai N, Byrnes K, Chatterjee D, Kakar S, Yeh M, Wu T, Zhang X, Jain D. Clinicopathologic characterization of hepatocellular adenomas in men: a multicenter experience. Human Pathology 2023, 138: 24-33. PMID: 37245629, DOI: 10.1016/j.humpath.2023.05.010.Peer-Reviewed Original ResearchConceptsHepatocellular adenomaHepatocellular carcinomaMalignant transformationMulticenter experienceMean ageWorld Health Organization classificationConcomitant hepatocellular carcinomaAndrogen receptor expressionBenign liver neoplasmUnclassified hepatocellular adenomaUncertain malignant potentialInflammatory hepatocellular adenomaΒ-catenin-activated hepatocellular adenomaClinicopathologic characterizationEntire cohortHCA casesCommon subtypeMalignant potentialOrganization classificationReproductive ageAllred score systemResection casesReceptor expressionHepatocellular neoplasmsLiver neoplasms
2022
Experimental VX2 Rabbit Liver Tumor Model in Carbon Tetrachloride–Induced Cirrhosis of the Liver
Santana J, Shewarega A, Nam D, Kahl V, Madoff D, Zhang X, Chapiro J. Experimental VX2 Rabbit Liver Tumor Model in Carbon Tetrachloride–Induced Cirrhosis of the Liver. Journal Of Vascular And Interventional Radiology 2022, 34: 404-408.e1. PMID: 36473611, PMCID: PMC11037556, DOI: 10.1016/j.jvir.2022.11.026.Peer-Reviewed Original ResearchConceptsLiver cirrhosisMale New Zealand white rabbitsRabbit liver tumor modelCirrhotic liver backgroundReproducible tumor growthVX2 liver cancerLeft hepatic lobeNew Zealand white rabbitsDuration of treatmentLiver tumor modelCross-sectional imagingVX2 rabbit liver tumor modelZealand white rabbitsHepatic lobeHistopathological evaluationMajor underlying factorHepatic tumorsIntragastric administrationHepatocellular carcinomaLiver tumorsLiver cancerCirrhosisUnmet needTumor growthVX2 tumorsProminent Pseudoacini in Focal Nodular Hyperplasia
Wang D, González IA, Russo PA, Jain D, Zhang X. Prominent Pseudoacini in Focal Nodular Hyperplasia. The American Journal Of Surgical Pathology 2022, 46: 1380-1385. PMID: 35749760, DOI: 10.1097/pas.0000000000001931.Peer-Reviewed Original ResearchConceptsFocal nodular hyperplasiaHepatocellular carcinomaNodular hyperplasiaFNH casesPotential diagnostic pitfallInspissated bileChronic cholestasisInitial biopsyPathologic featuresClinicopathologic correlationDiagnostic challengeNeedle biopsyDifferential diagnosisHepatocellular neoplasmsHepatocellular adenomaDiagnostic pitfallsMorphologic featuresLobular parenchymaStaining patternPseudoaciniBiliary transdifferentiationBiopsyHyperplasiaLesionsHepatocytes
2021
Hepatocellular Carcinoma
Jain A, Mazer B, Deng Y, Ciarleglio M, Jain D, Taddei T, Zhang X. Hepatocellular Carcinoma. American Journal Of Clinical Pathology 2021, 157: 305-313. PMID: 34542582, DOI: 10.1093/ajcp/aqab125.Peer-Reviewed Original ResearchConceptsAnaplastic tumor cellsHepatocellular carcinomaNoncirrhotic liverVascular invasionHistologic patternCirrhotic liverTumor cellsClear cell subtypePathogenesis of HCCHigh histologic gradeLarger tumor sizeHigher tumor stageHigh tumor gradeHigh rateHepatitis BHepatitis CLiver diseaseTumor sizeHistologic gradeTumor stageTumor gradePathologic differencesHCC casesRetrospective analysisPathology archivesCan primary hepatocellular carcinoma histomorphology predict extrahepatic metastasis?
Kumar D, Hafez O, Jain D, Zhang X. Can primary hepatocellular carcinoma histomorphology predict extrahepatic metastasis? Human Pathology 2021, 113: 39-46. PMID: 33905775, DOI: 10.1016/j.humpath.2021.04.008.Peer-Reviewed Original ResearchConceptsMetastatic hepatocellular carcinomaHepatocellular carcinomaHistologic patternHistomorphologic featuresPrimary tumorMetastatic tumorsMacrotrabecular-massive hepatocellular carcinomaCommon histologic patternPathogenesis of metastasisSignificant intratumoral heterogeneityExtrahepatic metastasesLymph nodesMicrovascular invasionAdrenal glandCommon subtypeNoncirrhotic liverCirrhotic liverCommon siteMetastatic tissuesLarge cohortAbdominal cavityHCC subtypesPathology archivesMetastasisHCC metastasisα-Fetoprotein mRNA in situ hybridisation is a highly specific marker of hepatocellular carcinoma: a multi-centre study
Lu SX, Huang YH, Liu LL, Zhang CZ, Yang X, Yang YZ, Shao CK, Li JM, Xie D, Zhang X, Jain D, Yun JP. α-Fetoprotein mRNA in situ hybridisation is a highly specific marker of hepatocellular carcinoma: a multi-centre study. British Journal Of Cancer 2021, 124: 1988-1996. PMID: 33824478, PMCID: PMC8184895, DOI: 10.1038/s41416-021-01363-4.Peer-Reviewed Original ResearchConceptsHepatocellular carcinomaHepatocytic lesionsDiagnosis of HCCLiver biopsy cohortHepatocyte paraffin 1Independent retrospective cohortsBenign liver lesionsMulti-center studyGood diagnostic valueNovel diagnostic biomarkersArginase-1 (Arg-1) proteinsΑ-fetoprotein mRNASurgical cohortRetrospective cohortBiopsy cohortHepPar-1Arg-1Liver lesionsDiagnostic biomarkersDiagnostic valueMalignancy lesionsLesionsGlypican3CohortSpecific markersDeep learning–assisted differentiation of pathologically proven atypical and typical hepatocellular carcinoma (HCC) versus non-HCC on contrast-enhanced MRI of the liver
Oestmann PM, Wang CJ, Savic LJ, Hamm CA, Stark S, Schobert I, Gebauer B, Schlachter T, Lin M, Weinreb JC, Batra R, Mulligan D, Zhang X, Duncan JS, Chapiro J. Deep learning–assisted differentiation of pathologically proven atypical and typical hepatocellular carcinoma (HCC) versus non-HCC on contrast-enhanced MRI of the liver. European Radiology 2021, 31: 4981-4990. PMID: 33409782, PMCID: PMC8222094, DOI: 10.1007/s00330-020-07559-1.Peer-Reviewed Original ResearchConceptsNon-HCC lesionsHepatocellular carcinomaHCC lesionsAtypical imagingGrading systemLI-RADS criteriaAtypical imaging featuresPrimary liver cancerTypical hepatocellular carcinomaAtypical hepatocellular carcinomaContrast-enhanced MRISensitivity/specificityLiver transplantMethodsThis IRBRetrospective studyLiver malignanciesImaging featuresLiver cancerAtypical featuresConclusionThis studyLesionsMRIClinical applicationCarcinomaImage-based diagnosis
2020
Hepatocellular Carcinoma Role of Pathology in the Era of Precision Medicine
Vyas M, Zhang X. Hepatocellular Carcinoma Role of Pathology in the Era of Precision Medicine. Clinics In Liver Disease 2020, 24: 591-610. PMID: 33012447, DOI: 10.1016/j.cld.2020.07.010.Peer-Reviewed Original ResearchConceptsHepatocellular carcinomaRole of pathologyTargetable genomic alterationsDistinct histologic subtypesConfirmation of diagnosisArchitectural growth patternRadiologic featuresHistologic subtypeHistopathologic diagnosisMolecular alterationsPersonalized careHeterogeneous tumorsPathologyPrecision oncologyGenomic alterationsPrecision medicineDiagnosisAlterationsFibronodular hepatocellular carcinoma—a new variant of liver cancer: clinical, pathological and radiological correlation
Tefera J, Revzin M, Chapiro J, Savic L, Mulligan D, Batra R, Taddei T, Jain D, Zhang X. Fibronodular hepatocellular carcinoma—a new variant of liver cancer: clinical, pathological and radiological correlation. Journal Of Clinical Pathology 2020, 74: 31-35. PMID: 32430483, PMCID: PMC7674234, DOI: 10.1136/jclinpath-2020-206574.Peer-Reviewed Original ResearchConceptsAdvanced Barcelona Clinic Liver Cancer stageBarcelona Clinic Liver Cancer stageScirrhous HCCMultiple rounded nodulesNon-peripheral washoutLiver Cancer stageRadiological featuresClinical featuresRadiological correlationCarcinoma variantsCancer stageHCC casesHepatocellular carcinomaLiver cancerFibrotic liverConventional HCCHCCLower ratesHigh rateRounded nodulesProgressionDistinct patternsCarcinomaSpecific variantsLesions
2019
Macrotrabecular Hepatocellular Carcinoma
Jeon Y, Benedict M, Taddei T, Jain D, Zhang X. Macrotrabecular Hepatocellular Carcinoma. The American Journal Of Surgical Pathology 2019, 43: 943-948. PMID: 31135484, DOI: 10.1097/pas.0000000000001289.Peer-Reviewed Original ResearchMeSH KeywordsAgedAlpha-FetoproteinsCarcinoma, HepatocellularDisease ProgressionFemaleHepatectomyHepatitis BHepatitis CHumansLiver CirrhosisLiver NeoplasmsLiver TransplantationMaleMiddle AgedNeoplasm GradingNeoplasm Recurrence, LocalNeoplasm StagingProgression-Free SurvivalRetrospective StudiesRisk FactorsTime FactorsTumor BurdenConceptsHepatocellular carcinomaHCC subtypesHigh alpha-fetoprotein levelsWorse recurrence-free survivalDistinct HCC subtypeHepatitis C infectionRecurrence-free survivalAlpha-fetoprotein levelsAnaplastic tumor cellsHigh histologic gradePoor overall survivalConventional hepatocellular carcinomaHigh recurrence rateHigher AJCC stageDetailed pathologic evaluationMacrotrabecular patternC infectionPrimary resectionHepatitis BOverall survivalPathologic evaluationAJCC stageClinicopathologic featuresHistologic subtypeRecurrence rate