2007
CTGF, intestinal stellate cells and carcinoid fibrogenesis.
Kidd M, Modlin I, Shapiro M, Camp R, Mane S, Usinger W, Murren J. CTGF, intestinal stellate cells and carcinoid fibrogenesis. World Journal Of Gastroenterology 2007, 13: 5208-16. PMID: 17876891, PMCID: PMC4171302, DOI: 10.3748/wjg.v13.i39.5208.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCarcinoid TumorCase-Control StudiesCells, CulturedConnective Tissue Growth FactorExtracellular MatrixFemaleFibrosisGastrointestinal NeoplasmsHumansImmediate-Early ProteinsIntercellular Signaling Peptides and ProteinsIntestine, SmallMaleMiddle AgedRNA, MessengerTissue Array AnalysisTransforming Growth Factor beta1ConceptsCarcinoid tumor patientsStellate cellsCarcinoid tumorsTumor patientsTissue microarrayGI carcinoid tumorsDevelopment of agentsGI carcinoidsPlasma CTGFSerum CTGFSystemic complicationsFibrotic mediatorsGastric carcinoidsHistological fibrosisPeritoneal fibrosisNormal mucosaTumor fibrosisFibrotic responseFibrosisFibrotic tissueRT-PCR analysisCTGFTGFbeta1Q-RT-PCR analysisSandwich ELISA
2006
Genetic Differentiation of Appendiceal Tumor Malignancy
Modlin IM, Kidd M, Latich I, Zikusoka MN, Eick GN, Mane SM, Camp RL. Genetic Differentiation of Appendiceal Tumor Malignancy. Annals Of Surgery 2006, 244: 52-60. PMID: 16794389, PMCID: PMC1570599, DOI: 10.1097/01.sla.0000217617.06782.d5.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAdolescentAdultAgedAged, 80 and overAntigens, NeoplasmApoptosis Regulatory ProteinsAppendiceal NeoplasmsAppendicitisBiomarkers, TumorCarcinoid TumorCell Cycle ProteinsChildChromogranin AChromograninsDiagnosis, DifferentialFemaleGene ExpressionGenetic MarkersHistone DeacetylasesHumansImmunohistochemistryMaleMiddle AgedNLR ProteinsNuclear ProteinsNucleosome Assembly Protein 1Repressor ProteinsReverse Transcriptase Polymerase Chain ReactionTrans-ActivatorsConceptsAppropriate surgical managementAppendiceal carcinoidsAppendiceal tumorsSurgical managementMAGE-D2Malignant appendiceal tumorsAppendiceal adenocarcinoidAdenocarcinoid tumorCarcinoid tumorsHistologic evidenceIncidental lesionsColorectal cancerPathologic criteriaQ-RT-PCRAppendiceal tissueGene expressionNormal mucosaTumor potentialCarcinoidsTumor behaviorAppendicitisAdenocarcinoidMorphologic assessmentTumor typesTumor malignancy
2005
Microsatellite instability and gene mutations in transforming growth factor‐beta type II receptor are absent in small bowel carcinoid tumors
Kidd M, Eick G, Shapiro MD, Camp RL, Mane SM, Modlin IM. Microsatellite instability and gene mutations in transforming growth factor‐beta type II receptor are absent in small bowel carcinoid tumors. Cancer 2005, 103: 229-236. PMID: 15599934, DOI: 10.1002/cncr.20750.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBase Pair MismatchBase SequenceCarcinoid TumorCase-Control StudiesCohort StudiesDNA Mutational AnalysisFemaleGene Expression Regulation, NeoplasticGenomic InstabilityHumansIntestinal NeoplasmsIntestine, SmallMaleMicrosatellite RepeatsMiddle AgedMolecular Sequence DataMutationProbabilityPrognosisProtein Serine-Threonine KinasesReceptor, Transforming Growth Factor-beta Type IIReceptors, Transforming Growth Factor betaReverse Transcriptase Polymerase Chain ReactionSensitivity and SpecificityConceptsSmall bowel carcinoidsSmall bowel carcinoid tumorsCarcinoid tumorsGrowth factor beta type II receptorMicrosatellite instabilityMismatch repair genesType II receptorLiver metastasesNormal mucosaII receptorsBAT-26Carcinoid tumor metastasisVariable expressionMicrosatellite stable phenotypeRepair genes