2018
The Value of Negative Diagnosis in Thyroid Fine-Needle Aspiration: a Retrospective Study with Histologic Follow-Up
Abi-Raad R, Prasad M, Baldassari R, Schofield K, Callender GG, Chhieng D, Adeniran AJ. The Value of Negative Diagnosis in Thyroid Fine-Needle Aspiration: a Retrospective Study with Histologic Follow-Up. Endocrine Pathology 2018, 29: 269-275. PMID: 29949024, DOI: 10.1007/s12022-018-9536-5.Peer-Reviewed Original ResearchConceptsFine-needle aspirationThyroid fine-needle aspirationFalse negative rateBenign diagnosisFNA diagnosisIncidence of malignancySubsequent surgical resectionCategory of patientsPapillary-like nuclear featuresNoninvasive follicular thyroid neoplasmLarge academic centerPapillary thyroid carcinomaThyroid FNA resultsFalse-negative casesFollicular thyroid neoplasmSurgical resectionRetrospective reviewBenign goiterInadequate biopsiesLymphocytic thyroiditisNeoplastic casesRetrospective studyTumor sizeNIFTP casesSurgical follow
2015
Diagnostic application of KRAS mutation testing in uterine microglandular proliferations
Hong W, Abi-Raad R, Alomari AK, Hui P, Buza N. Diagnostic application of KRAS mutation testing in uterine microglandular proliferations. Human Pathology 2015, 46: 1000-1005. PMID: 25997988, DOI: 10.1016/j.humpath.2015.03.010.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedAged, 80 and overBiopsyCell ProliferationCervix UteriDiagnosis, DifferentialDNA Mutational AnalysisEndometrial HyperplasiaEndometrial NeoplasmsFemaleHumansMiddle AgedMutationPredictive Value of TestsProto-Oncogene ProteinsProto-Oncogene Proteins p21(ras)Ras ProteinsConceptsKRAS mutation analysisEndometrial adenocarcinomaMicroglandular hyperplasiaMicroglandular patternKRAS mutationsCareful morphological assessmentEndometrial mucinous carcinomaKRAS mutation testingCases of EMAMutation analysisFrequent KRAS mutationsElectronic medical recordsDifferential diagnostic toolHigh mitotic activityEndometrial biopsyImmunohistochemical workupUterine cervixMucinous carcinomaClinical historyDiagnostic challengeDiagnostic dilemmaGlandular proliferationMucinous lesionsMedical recordsEAC cases
2013
Frequent KRAS mutation in complex mucinous epithelial lesions of the endometrium
Alomari A, Abi-Raad R, Buza N, Hui P. Frequent KRAS mutation in complex mucinous epithelial lesions of the endometrium. Modern Pathology 2013, 27: 675-680. PMID: 24186144, DOI: 10.1038/modpathol.2013.186.Peer-Reviewed Original ResearchConceptsPositive predictive valueMucinous lesionsKRAS mutationsMucinous changeMucinous adenocarcinomaEndometrial mucinous carcinomaHigh positive predictive valueComplex atypical hyperplasiaRisk stratification algorithmAtypical complex hyperplasiaImportant prognostic indicatorFrequent KRAS mutationsKRAS mutation analysisComplex hyperplasiaHysterectomy specimensClinical progressionEndometrial lesionsMucinous carcinomaAtypical hyperplasiaPrognostic indicatorMucinous differentiationEpithelial lesionsCurettage casesStratification algorithmPredictive value