2017
Hemoglobin C trait accentuates erythrocyte dehydration in hereditary xerocytosis
Yang E, Voelkel EB, Lezon‐Geyda K, Schulz VP, Gallagher PG. Hemoglobin C trait accentuates erythrocyte dehydration in hereditary xerocytosis. Pediatric Blood & Cancer 2017, 64 PMID: 28121068, PMCID: PMC5858911, DOI: 10.1002/pbc.26444.Peer-Reviewed Original ResearchConceptsMean corpuscular hemoglobin concentrationElevated mean corpuscular hemoglobin concentrationHemoglobin C traitErythrocyte dehydrationC traitHereditary xerocytosisCorpuscular hemoglobin concentrationAcute hemolysisHbC traitHemoglobin concentrationEvidence of dehydrationOsmotic gradient ektacytometryPatientsPIEZO1 mutationsEktacytometryGenetic studies
2010
Determinants of erythrocyte hydration
Rinehart J, Gulcicek EE, Joiner CH, Lifton RP, Gallagher PG. Determinants of erythrocyte hydration. Current Opinion In Hematology 2010, 17: 191-197. PMID: 20182354, PMCID: PMC4155397, DOI: 10.1097/moh.0b013e32833800d0.Peer-Reviewed Original ResearchConceptsSickle cell diseaseErythrocyte hydrationCell diseaseNew therapeutic targetsGardos channel activationClinical complicationsPrimary disorderSecondary disordersTherapeutic targetErythrocyte dehydrationDisease preventionRelated disordersSolute homeostasisBiologic studiesDisordersChannel activationKCl cotransportDiseaseErythrocyte waterHomeostasisErythrocytesAnion transportersPremature destructionRecent studiesComplications