Regulation of TGF-β ligand and receptor expression in neonatal rat lungs exposed to chronic hypoxia
Vicencio AG, Eickelberg O, Stankewich MC, Kashgarian M, Haddad GG. Regulation of TGF-β ligand and receptor expression in neonatal rat lungs exposed to chronic hypoxia. Journal Of Applied Physiology 2002, 93: 1123-1130. PMID: 12183510, DOI: 10.1152/japplphysiol.00031.2002.Peer-Reviewed Original ResearchConceptsRat lungChronic hypoxiaArrest of alveolarizationTGF-beta levelsPostnatal day 14 ratsBronchoalveolar lavage fluidTGF-beta receptor INeonatal rat lungSprague-Dawley ratsPostnatal day 14Day 14 ratsTGF-beta activityWk of lifeTGF-beta systemEffects of hypoxiaHypoxic adultsWestern blot analysisLavage fluidReceptor expressionLong-term effectsAdult ratsAlveolar epitheliumImmunohistochemical analysisModulatory effectsDay 14