2001
Molecular mechanisms of TGF‐β antagonism by interferon γ and cyclosporine A in lung fibroblasts
EICKELBERG O, PANSKY A, KOEHLER E, BIHL M, TAMM M, HILDEBRAND P, PERRUCHOUD A, KASHGARIAN M, ROTH M. Molecular mechanisms of TGF‐β antagonism by interferon γ and cyclosporine A in lung fibroblasts. The FASEB Journal 2001, 15: 797-806. PMID: 11259398, DOI: 10.1096/fj.00-0233com.Peer-Reviewed Original ResearchMeSH KeywordsCells, CulturedCollagenCyclosporineDNA-Binding ProteinsExtracellular MatrixFibroblastsGenes, ReporterHumansInterferon-gammaLungModels, BiologicalOligonucleotides, AntisenseProto-Oncogene Proteins c-junPulmonary FibrosisSignal TransductionSTAT1 Transcription FactorTrans-ActivatorsTranscription Factor AP-1Transforming Growth Factor betaConceptsCollagen depositionLung fibroblastsIFN-gammaExcess extracellular matrix depositionGrowth factor-beta activityPrimary human lung fibroblastsFibrotic lung diseaseHuman lung fibroblastsTGF-beta antagonismAP-1IFN-gamma treatmentExtracellular matrix depositionLung fibrosisFatal conditionLung diseaseMolecular mechanismsPathological featuresInterferon γTranscription factor AP-1Future therapiesPharmacological agentsJunD homodimersFactor AP-1Novel targetDirect inhibition
1995
PDGF and TGF-β mediate collagen production by mesangial cells exposed to advanced glycosylation end products
Throckmorton D, Brogden A, Min B, Rasmussen H, Kashgarian M. PDGF and TGF-β mediate collagen production by mesangial cells exposed to advanced glycosylation end products. Kidney International 1995, 48: 111-117. PMID: 7564067, DOI: 10.1038/ki.1995.274.Peer-Reviewed Original Research
1993
Spatial organization of the extracellular matrix modulates the expression of PDGF-receptor subunits in mesangial cells
Marx M, Daniel T, Kashgarian M, Madri J. Spatial organization of the extracellular matrix modulates the expression of PDGF-receptor subunits in mesangial cells. Kidney International 1993, 43: 1027-1041. PMID: 8510381, DOI: 10.1038/ki.1993.145.Peer-Reviewed Original ResearchConceptsPDGF receptor subunitsMesangial cell phenotypeCell surfaceExtracellular matrixCell phenotypeExtracellular matrix environmentSpatial organizationPDGF responsivenessPDGF receptor alphaTwo-dimensional cultureMulticellular structuresThree-dimensional cultureMetabolic labelingDifferential expressionQuiescent cellsRat mesangial cell growthCell growthPDGF isoforms AASubunitsMatrix environmentCell proliferationPDGF isoformsReceptor subunitsUltrastructural analysisSurface expressionEffect of transforming growth factor-β on extracellular matrix productionby cultured rat mesangial cells
ISHIMURA E, MORII H, STERZEL R, KASHGARIAN M. Effect of transforming growth factor-β on extracellular matrix productionby cultured rat mesangial cells. 日本腎臓学会誌 1993, 35: 311-320. PMID: 8341006, DOI: 10.14842/jpnjnephrol1959.35.311.Peer-Reviewed Original ResearchConceptsNorthern blottingCultured rat mesangial cellsRat mesangial cellsCollagen IExtracellular matrix constituentsMesangial cellsGrowth factorEnzyme-linked immunoadsorbent assayGene expressionProtein productionSingle growth factorECM constituentsProtein synthesisGenetic expressionMatrix componentsLamininExpressionGlomerular remodelingECM accumulationTGF-beta administrationBlottingMRNA expressionMatrix constituentsCellsGlomerular injury
1992
The pathobiology of the mesangium
Kashgarian M, Sterzel R. The pathobiology of the mesangium. Kidney International 1992, 41: 524-529. PMID: 1573822, DOI: 10.1038/ki.1992.74.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DivisionCytokinesExtracellular MatrixGlomerular MesangiumHumansSignal TransductionTransforming Growth Factor betaConceptsGlomerular diseaseAdvanced glomerular lesionsProgressive glomerular diseaseGlomerular capillary tuftDiabetic nephropathyIgA nephropathyMesangiocapillary glomerulonephritisGlomerular lesionsHistologic abnormalitiesGlomerular morphologySegmental glomerulosclerosisChronic diseasesSclerotic responseProliferative responseEpithelial cell layerMesangial matrixMesangial cellsCapillary tuftMesangiumDiseaseNephropathyCell layerObvious involvementPathobiologyMammalian kidney
1989
Formation of extracellular matrix by cultured rat mesangial cells.
Ishimura E, Sterzel R, Budde K, Kashgarian M. Formation of extracellular matrix by cultured rat mesangial cells. American Journal Of Pathology 1989, 134: 843-55. PMID: 2650558, PMCID: PMC1879799.Peer-Reviewed Original Research
1986
Mesangial cell hillocks. Nodular foci of exaggerated growth of cells and matrix in prolonged culture.
Sterzel R, Lovett D, Foellmer H, Perfetto M, Biemesderfer D, Kashgarian M. Mesangial cell hillocks. Nodular foci of exaggerated growth of cells and matrix in prolonged culture. American Journal Of Pathology 1986, 125: 130-40. PMID: 3535527, PMCID: PMC1888434.Peer-Reviewed Original ResearchConceptsMesangial cellsNecrotic cell debrisCollagen type IMesangial matrix productionCultured mesangial cellsGlomerular mesangial cellsIsolated rat glomeruliType ISpecific rabbit polyclonal antibodiesNodular fociFetal calf serumDiseased glomeruliMC proliferationRabbit polyclonal antibodyStellate cellsNormal glomeruliMatrix proteinsInterstitial collagen types ICell debrisImmunocytochemical studyNodular accumulationMetabolic stimuliIntracellular fibrilsRat glomeruliGlomeruli
1985
Pathology of Small Blood Vessel Disease in Hypertension
Kashgarian M. Pathology of Small Blood Vessel Disease in Hypertension. American Journal Of Kidney Diseases 1985, 5: a104-a110. PMID: 2581443, DOI: 10.1016/s0272-6386(85)80072-x.Peer-Reviewed Original ResearchMeSH KeywordsArteriolesArteriosclerosisExtracellular MatrixHumansHyalinHyperplasiaHypertension, RenovascularKidneyNecrosisConceptsHyaline arteriolosclerosisPerpetuation of hypertensionSmall blood vessel diseaseBlood vessel diseasesArteriolar diseaseMyointimal hyperplasiaVessel diseasePathogenic rolePathophysiologic consequencesAnatomic correlatesHypertensionTransmural pressureArteriolosclerosisLesionsDiseaseExtracellular matrixArteriolonecrosisHyperplasiaArteriolesPathogenesisTherapyPathology