1998
Antibodies against mesangial cells and their secretory products in chronic renal allograft rejection in the rat.
Paul L, Muralidharan J, Muzaffar S, Manting E, Valentin J, de Heer E, Kashgarian M. Antibodies against mesangial cells and their secretory products in chronic renal allograft rejection in the rat. American Journal Of Pathology 1998, 152: 1209-23. PMID: 9588890, PMCID: PMC1858589.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoantibodiesAutoantigensBasement MembraneBiglycanBlotting, WesternCells, CulturedChronic DiseaseDecorinEndothelium, VascularExtracellular Matrix ProteinsFlow CytometryFluorescent Antibody Technique, IndirectGlomerular MesangiumGraft RejectionKidney TransplantationMaleProteoglycansRatsRats, Inbred F344Rats, Inbred LewTransplantation, HomologousConceptsMesangial cell culture supernatantsChronic renal allograft rejectionRenal allograft rejectionMesangial cellsChronic rejectionAllograft rejectionCell culture supernatantsChronic renal transplant rejectionFlow cytometryWestern blotEndothelial cellsGlomerular basement membrane antigenPost-transplant seraRenal transplant rejectionCell-mediated immunityPost-immunization seraPresence of antibodiesMesangial cell surfaceStrong autoantibody responseCulture supernatantsCultured mesangial cellsIndirect immunofluorescent studiesBasement membrane antigensIndirect immunofluorescent stainingTissue repair process
1990
Morphological and physiological responses to aldosterone: time course and sodium dependence
Wade J, Stanton B, Field M, Kashgarian M, Giebisch G. Morphological and physiological responses to aldosterone: time course and sodium dependence. American Journal Of Physiology 1990, 259: f88-f94. PMID: 2375395, DOI: 10.1152/ajprenal.1990.259.1.f88.Peer-Reviewed Original ResearchConceptsOsmotic minipumpsMale Sprague-Dawley ratsPrincipal cellsElevated aldosterone levelsSprague-Dawley ratsImplanted osmotic minipumpsTime courseBasolateral membraneAldosterone levelsIntravenous infusionAldosterone treatmentPhysiological elevationReplacement infusionsAldosteroneAcute exposureChronic exposureDetectable proliferationFurther elevationDays of exposureSodium dependenceBasolateral membrane areaMinipumpsInfusionSecretionExposure
1986
Progressive Glomerular Sclerosis in Experimental Antiglomerular Basement Membrane Glomerulonephritis
Foellmer H, Sterzel R, Kashgarian M. Progressive Glomerular Sclerosis in Experimental Antiglomerular Basement Membrane Glomerulonephritis. American Journal Of Kidney Diseases 1986, 7: 5-11. PMID: 3510536, DOI: 10.1016/s0272-6386(86)80050-6.Peer-Reviewed Original ResearchConceptsGlomerular filtration rateAntiglomerular basement membrane glomerulonephritisProgressive glomerular sclerosisGlomerular sclerosisPara-aminohippuric acidGlomerular hypercellularityFiltration fractionWistar ratsInitial inflammatory changesNormal renal clearanceIntrinsic glomerular cellsChronic glomerulosclerosisRenal insufficiencyInflammatory changesAcute phaseChronic phaseSignificant proteinuriaFiltration rateLeukocytic infiltrationCrescent formationFunctional abnormalitiesSclerotic processRenal clearanceGlomerular cellsGlomerulonephritis
1984
Cellular ultrastructure of Amphiuma distal nephron: effects of exposure to potassium
Stanton B, Biemesderfer D, Stetson D, Kashgarian M, Giebisch G. Cellular ultrastructure of Amphiuma distal nephron: effects of exposure to potassium. American Journal Of Physiology 1984, 247: c204-c216. PMID: 6476108, DOI: 10.1152/ajpcell.1984.247.3.c204.Peer-Reviewed Original ResearchConceptsEarly distal tubuleDistal tubulesDistal nephronPotassium adaptationRenal distal nephronLarge cell typeLate distal tubuleCortical collecting tubuleSmooth muscle cellsLate distalAfferent arteriolesEffects of exposureJuxtaglomerular apparatusMammalian cortical collecting tubuleCollecting tubuleEarly distalHenle's loopBasolateral membrane surface densityMuscle cellsPrincipal cellsCellular mechanismsNephronStereological techniquesTubulesUseful preparation
1982
Mesangial disposal of glomerular immune deposits in acute malarial glomerulonephritis of rats.
Sterzel R, Ehrich J, Lucia H, Thomson D, Kashgarian M. Mesangial disposal of glomerular immune deposits in acute malarial glomerulonephritis of rats. Laboratory Investigation 1982, 46: 209-14. PMID: 7038293.Peer-Reviewed Original ResearchConceptsGlomerular immune depositsImmune depositsElectron-dense depositsDay 10Day 20Young Sprague-Dawley ratsRenal functional damageUrinary protein excretionInfiltration of monocytesGlomerular cell countSprague-Dawley ratsEsterase-positive monocytesGlomerular basement membraneAcute malariaProtein excretionGlomerular injuryMesangial distributionSerum urea valuesDay 100Granular depositionImmune complexesFunctional damageNormal rangeMesangial matrixCell count
1980
Activation of the Classic Complement Pathway in Patients with the C3 Nephritic Factor
McLean R, Siegel N, Kashgarian M. Activation of the Classic Complement Pathway in Patients with the C3 Nephritic Factor. Nephron 1980, 25: 57-64. PMID: 6986570, DOI: 10.1159/000181754.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBasement MembraneBiopsyCapillariesChildComplement ActivationComplement C3 Nephritic FactorComplement Inactivator ProteinsComplement Pathway, ClassicalFemaleFluorescent Antibody TechniqueGlomerulonephritisHemolysisHumansImmunoelectrophoresis, Two-DimensionalKidneyLipodystrophyMagnesiumMaleMicroscopy, ElectronConceptsC3 nephritic factorNephritic factorPartial lipodystrophyClassic complement pathwayDense deposit diseaseDense intramembranous depositsRenal diseaseDeposit diseaseIntramembranous depositsPatientsFactor assaysComplement pathwayComplement componentsUltrastructural evidenceCurrent criteriaLipodystrophyDiseaseType IHemolytic assayMCGNAssays
1977
Renal disease.
Kashgarian M, Hayslett J, Spargo B. Renal disease. American Journal Of Pathology 1977, 89: 183-272. PMID: 143893, PMCID: PMC2032191.Peer-Reviewed Original Research
1975
Glomerulonephropathy.
Hayslett J, Siegel N, Kashgarian M. Glomerulonephropathy. Advances In Internal Medicine 1975, 20: 215-48. PMID: 1090119.Peer-Reviewed Original ResearchAdolescentAdultAmyloidosisBasement MembraneBlood Coagulation DisordersChildChild, PreschoolDiabetic NephropathiesFemaleGlomerulonephritisGranulomatosis with PolyangiitisHematuriaHumansImmunoglobulin GImmunoglobulin MKidney DiseasesKidney GlomerulusLupus Erythematosus, SystemicMaleMiddle AgedNephrosis, LipoidProteinuriaStreptococcal InfectionsUremia
1971
Successful Treatment of Renal Failure in Goodpasture's Syndrome
Hayslett J, Berte J, Kashgarian M. Successful Treatment of Renal Failure in Goodpasture's Syndrome. JAMA Internal Medicine 1971, 127: 953-957. PMID: 5560872, DOI: 10.1001/archinte.1971.00310170161025.Peer-Reviewed Original ResearchConceptsGoodpasture's syndromeRenal failureYale-New Haven HospitalEvaluation of hemoptysisSymptoms of bronchospasmFurther renal deteriorationGlomerular basement membraneAcute bronchitisRenal deteriorationRenal insufficiencyPulmonary functionPulmonary tuberculosisSuccessful treatmentRapid progressionProlonged survivalImmune responseSerial studiesSyndromeWhite womenHemoptysisRecent evidenceBasement membraneComplete restorationWomenBronchospasm