2001
K+-induced HSP-72 expression is mediated via rapid Ca2+ influx in renal epithelial cells
Eickelberg O, Geibel J, Seebach F, Giebisch G, Kashgarian M. K+-induced HSP-72 expression is mediated via rapid Ca2+ influx in renal epithelial cells. American Journal Of Physiology. Renal Physiology 2001, 281: f280-f287. PMID: 11457719, DOI: 10.1152/ajprenal.2001.281.2.f280.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCalciumCalcium Channel BlockersCell LineDiltiazemEgtazic AcidEnzyme InhibitorsEpithelial CellsGallic AcidGenes, ReporterHeat-Shock ProteinsHSP72 Heat-Shock ProteinsImmunoblottingKidney Tubules, ProximalMicroscopy, ConfocalPotassiumPromoter Regions, GeneticRecombinant Fusion ProteinsSodiumSwineThapsigarginUrotheliumConceptsHSP 72 expressionPromoter activityHSP 72Protein expressionProtective cellular responseLuciferase reporter geneHSP-25Heat shock protein expressionRenal epithelial cellsTranscriptional inductionShock protein expressionIonic stressReporter geneHSP-90 levelsHSC 73Cellular responsesChannel blocker diltiazemIntracellular lumenWestern blot analysisChelator EGTA-AMPathophysiological stimuliBlot analysisConfocal microscopyProtein levelsExtracellular space
1989
Aldosterone induction of electrogenic sodium transport in the apical membrane vesicles of rat distal colon*
Rajendran V, Kashgarian M, Binder H. Aldosterone induction of electrogenic sodium transport in the apical membrane vesicles of rat distal colon*. Journal Of Biological Chemistry 1989, 264: 18638-18644. PMID: 2553716, DOI: 10.1016/s0021-9258(18)51514-3.Peer-Reviewed Original ResearchConceptsDistal colonRat distal colonNa-H exchangeElectrogenic sodium transportSodium transportExperimental ratsMicroM amilorideAmiloride-sensitive electrogenic sodium transportNormal rat distal colonEffects of aldosteroneElectroneutral sodium absorptionSodium concentrationApical membrane vesiclesAnalogues of amilorideVoltage-clamp conditionsDietary sodiumNormal ratsAldosterone inductionSodium absorptionColonComparable inhibitionRatsAmilorideAldosteronePotent inhibitor
1987
Response of collecting tubule cells to aldosterone and potassium loading
Kashgarian M, Ardito T, Hirsch D, Hayslett J. Response of collecting tubule cells to aldosterone and potassium loading. American Journal Of Physiology 1987, 253: f8-f14. PMID: 3605352, DOI: 10.1152/ajprenal.1987.253.1.f8.Peer-Reviewed Original ResearchConceptsInitial collecting tubuleCortical collecting tubuleBasolateral membrane surfaceCollecting tubuleChronic potassium loadingElevated levelsDuct structuresPotassium loadingSite of actionPlasma levelsRat modelOuter stripeInner stripeTubule cellsNormal physiological levelsControl valuesAldoMorphometric studyAldosteronePhysiological levelsDuct systemTubulesConcomitant changesDuct
1984
Role of aldosterone in the mechanism of potassium adaptation in the initial collecting tubule
Hirsch D, Kashgarian M, Boulpaep E, Hayslett J. Role of aldosterone in the mechanism of potassium adaptation in the initial collecting tubule. Kidney International 1984, 26: 798-807. PMID: 6099857, DOI: 10.1038/ki.1984.221.Peer-Reviewed Original ResearchConceptsInitial collecting tubuleCollecting tubuleDistal convolutionAldosterone levelsPotassium adaptationChronic potassium loadingMineralocorticoid-sensitive tissuesRole of aldosteronePlasma aldosterone levelsAction of aldosteroneIntact adrenal glandsPotassium loadingPhysiological plasma levelsChronic hyperaldosteronismTransepithelial potential differenceChronic administrationEpithelial changesAdrenal glandPlasma levelsDietary potassium loadingBasal valuesAldosteroneTubule cellsNephron segmentsTarget tissuesCellular ultrastructure of Amphiuma distal nephron: effects of exposure to potassium
Stanton B, Biemesderfer D, Stetson D, Kashgarian M, Giebisch G. Cellular ultrastructure of Amphiuma distal nephron: effects of exposure to potassium. American Journal Of Physiology 1984, 247: c204-c216. PMID: 6476108, DOI: 10.1152/ajpcell.1984.247.3.c204.Peer-Reviewed Original ResearchConceptsEarly distal tubuleDistal tubulesDistal nephronPotassium adaptationRenal distal nephronLarge cell typeLate distal tubuleCortical collecting tubuleSmooth muscle cellsLate distalAfferent arteriolesEffects of exposureJuxtaglomerular apparatusMammalian cortical collecting tubuleCollecting tubuleEarly distalHenle's loopBasolateral membrane surface densityMuscle cellsPrincipal cellsCellular mechanismsNephronStereological techniquesTubulesUseful preparation
1980
Changes in membrane surfaces of collecting duct cells in potassium adaptation
Rastegar A, Biemesderfer D, Kashgarian M, Hayslett J, Kashgarian M. Changes in membrane surfaces of collecting duct cells in potassium adaptation. Kidney International 1980, 18: 293-301. PMID: 6257963, DOI: 10.1038/ki.1980.139.Peer-Reviewed Original ResearchAmplification of cell membrane surface in potassium adaptation.
Kashgarian M, Taylor C, Binder H, Hayslett J. Amplification of cell membrane surface in potassium adaptation. Laboratory Investigation 1980, 42: 581-8. PMID: 6248685.Peer-Reviewed Original Research
1978
Micropuncture study on the effects of lithium on proximal and distal tubule function in the rat kiney
Hecht B, Kashgarian M, Forrest J, Hayslett J. Micropuncture study on the effects of lithium on proximal and distal tubule function in the rat kiney. Pflügers Archiv - European Journal Of Physiology 1978, 377: 69-74. PMID: 569282, DOI: 10.1007/bf00584376.Peer-Reviewed Original ResearchConceptsFractional reabsorptionDistal tubule functionProximal fractional reabsorptionPlasma lithium concentrationReabsorption of bicarbonateMultiple nephron segmentsEnd-proximal tubuleEffects of lithiumLithium treatmentPotassium secretionAntidiuretic hormoneDistal tubulesMicropuncture studiesTubule functionProximal tubulesDistal convolutionExperimental animalsNephron segmentsReabsorptionDistal portionTubulesPrevious studiesRatsSodiumHormone
1976
Ion transport and structure of urinary bladder epithelium of Amphiuma
Mullen T, Kashgarian M, Biemesderfer D, Giebisch G, Biber T. Ion transport and structure of urinary bladder epithelium of Amphiuma. American Journal Of Physiology 1976, 231: 501-508. PMID: 961904, DOI: 10.1152/ajplegacy.1976.231.2.501.Peer-Reviewed Original Research
1975
Effect of lithium on water and electrolyte metabolism.
Galla J, Forrest J, Hecht B, Kashgarian M, Hayslett J. Effect of lithium on water and electrolyte metabolism. The Yale Journal Of Biology And Medicine 1975, 48: 305-14. PMID: 1202760, PMCID: PMC2595176.Peer-Reviewed Original ResearchConceptsEffects of lithiumElectrolyte transportSame nephron segmentsAction of vasopressinChronic administrationOral intakeLithium administrationIntravenous infusionPlasma levelsPotassium secretionElectrolyte metabolismMaximum urineCorticomedullary gradientUrinary acidificationNephron segmentsSustained increaseDistal portionAdministrationNatriuresisInfusionRatsVasopressinIntakeNephronSecretion
1974
Na-K-ATPase-mediated seasonal variation of sodium transport in Necturus kidney
Spector D, Hayslett J, Kashgarian M. Na-K-ATPase-mediated seasonal variation of sodium transport in Necturus kidney. American Journal Of Physiology 1974, 227: 873-877. PMID: 4279558, DOI: 10.1152/ajplegacy.1974.227.4.873.Peer-Reviewed Original ResearchEffect of luminal permeability on net transport across the amphibian proximal tubule
Stroup R, Weinman E, Hayslett J, Kashgarian M. Effect of luminal permeability on net transport across the amphibian proximal tubule. American Journal Of Physiology 1974, 226: 1110-1116. PMID: 4824863, DOI: 10.1152/ajplegacy.1974.226.5.1110.Peer-Reviewed Original Research
1973
The ultrastructure of the adrenal zona glomerulosa of rats on patassium-supplemented or sodium-depleted diets.
Domoto D, Boyd J, Mulrow P, Kashgarian M. The ultrastructure of the adrenal zona glomerulosa of rats on patassium-supplemented or sodium-depleted diets. American Journal Of Pathology 1973, 72: 433-46. PMID: 4728893, PMCID: PMC1904037.Peer-Reviewed Original ResearchConceptsSodium-deficient dietAldosterone productionPrincipal ultrastructural changesZona glomerulosa cellsAdrenal zona glomerulosaSodium-depleted animalsUltrastructural changesSodium-depleted dietGroups of animalsZona glomerulosaGlomerulosa cellsAdrenal cortexControl animalsMorphologic changesRatsSteroid synthesisMitochondrial changesDietAnimalsDaysInitial increaseGlomerulosaCortexCristae
1970
Effects of Chloride Restriction and Depletion on Acid-Base Balance and Chloride Conservation in the Rat
Luke R, Warren Y, Kashgarian M, Levitin H. Effects of Chloride Restriction and Depletion on Acid-Base Balance and Chloride Conservation in the Rat. Clinical Science 1970, 38: 385-396. PMID: 5442558, DOI: 10.1042/cs0380385.Peer-Reviewed Original ResearchConceptsUrinary net acid excretionNet acid excretionAcid excretionPlasma bicarbonateProximal tubulesBicarbonate absorptionDietary chloride restrictionProximal tubular absorptionUrinary acid excretionEndogenous acid productionLow chloride dietDegree of elevationAcid-base balanceDietary sodiumPlasma chlorideSerum bicarbonateTubular absorptionPhosphate excretionRespiratory acidosisMicropuncture experimentsDepleted ratsHypochloraemiaRatsExcretionRates of sodium
1961
Renal Tubular Acidosis and Renal Potassium Wasting Acquired as a Result of Hypercalcemic Nephropathy
Ferris T, Kashgarian M, Levitin H, Brandt I, Epstein F. Renal Tubular Acidosis and Renal Potassium Wasting Acquired as a Result of Hypercalcemic Nephropathy. New England Journal Of Medicine 1961, 265: 924-928. PMID: 13892591, DOI: 10.1056/nejm196111092651902.Peer-Reviewed Original Research
1959
Effect of acute potassium deficiency on susceptibility to infection with particular reference to the kidney.
Carone F, Kashgarian M, Epstein F. Effect of acute potassium deficiency on susceptibility to infection with particular reference to the kidney. The Yale Journal Of Biology And Medicine 1959, 32: 100-8. PMID: 13807844, PMCID: PMC2604070.Peer-Reviewed Original Research