2008
Disruption of Myosin 1e Promotes Podocyte Injury
Krendel M, Kim SV, Willinger T, Wang T, Kashgarian M, Flavell RA, Mooseker MS. Disruption of Myosin 1e Promotes Podocyte Injury. Journal Of The American Society Of Nephrology 2008, 20: 86-94. PMID: 19005011, PMCID: PMC2615733, DOI: 10.1681/asn.2007111172.Peer-Reviewed Original ResearchConceptsChronic renal injuryNormal glomerular filtrationGlomerular basement membraneRenal injuryKidney inflammationPodocyte foot processesGlomerular diseasePodocyte injuryGlomerular filtrationRenal tissueFoot processesPodocyte functionBasement membraneInjuryUltrastructural levelDiseaseMiceType IProteinuriaInflammationKidneyImportant rolePodocytes
1983
Role of angiotensin II-induced renal functional changes in mesangial deposition of exogenous ferritin in rats.
Stein H, Feddergreen W, Kashgarian M, Sterzel R. Role of angiotensin II-induced renal functional changes in mesangial deposition of exogenous ferritin in rats. Laboratory Investigation 1983, 49: 270-80. PMID: 6350702.Peer-Reviewed Original ResearchConceptsBlood pressureFiltration fractionMesangial localizationAngiotensin IIFunctional changesAcute angiotensin IIAminohippuric acid clearanceRenal functional changesSystolic blood pressureExcretion of albuminSingle intravenous doseGlomerular capillary permeabilityGroups of ratsInjection of ferritinPressor doseAcid clearanceIntravenous doseMesangial depositionMesangial accumulationFerritin concentrationInulin clearanceTreatment periodRenal tissueSerial measurementsFerritin depositionDisposal of ferritin in the glomerular mesangium of rats
Sterzel R, Perfetto M, Biemesderfer D, Kashgarian M. Disposal of ferritin in the glomerular mesangium of rats. Kidney International 1983, 23: 480-488. PMID: 6188874, DOI: 10.1038/ki.1983.45.Peer-Reviewed Original ResearchConceptsGlomerular mesangiumDay 3DE ratsVascular poleIa-negative cellsMacula densa cellsIa-positive cellsGlomerular stainingMacula densaMesangial patternIntravenous injectionRenal tissueFerritin injectionIa antigensGlomerular tuftBearing cellsMesangial matrixMesangial cellsLacis areaMesangiumRatsCryostat sectionsInterstitial areaStudy periodFerritin
1981
Wegener's Granulomatosis — Clinical-Pathologic Correlations and Long-Term Course
Appel G, Gee B, Kashgarian M, Hayslett J. Wegener's Granulomatosis — Clinical-Pathologic Correlations and Long-Term Course. American Journal Of Kidney Diseases 1981, 1: 27-37. PMID: 7332000, DOI: 10.1016/s0272-6386(81)80008-x.Peer-Reviewed Original ResearchConceptsEnd-stage renal diseaseModern immunosuppressive therapyLong-term courseClinical-pathologic entityLong-term reportsImmunosuppressive therapyRenal involvementRenal manifestationsSerum creatinineWegener's granulomatosisRenal diseaseEventual prognosisSingle institutionLight microscopic morphologyPathologic correlationMedical CenterRenal tissueDisease processRespiratory tissuesSpecific diagnosisPotential diagnosisPatientsDiagnosisGranulomatosisBiopsy
1974
Compensatory adaptation of structure and function following progressive renal ablation
Kaufman J, DiMeola H, Siegel N, Lytton B, Kashgarian M, Hayslett J. Compensatory adaptation of structure and function following progressive renal ablation. Kidney International 1974, 6: 10-17. PMID: 4419711, DOI: 10.1038/ki.1974.72.Peer-Reviewed Original ResearchConceptsRenal ablationRenal tissueNephron glomerular filtration rateCompensatory adaptationGlomerular filtration rateClearance of inulinRenal insufficiencyUninephrectomized ratsFour-week intervalsFiltration rateRenal massesGroup BGroup AControl animalsGroup CLE ratsFunctional changesMass of tissueSegmental lossRatsSurgeryAdaptive changesAblationClearanceTissue
1969
Mechanism of change in the excretion of sodium per nephron when renal mass is reduced
Hayslett J, Kashgarian M, Epstein F. Mechanism of change in the excretion of sodium per nephron when renal mass is reduced. Journal Of Clinical Investigation 1969, 48: 1002-1006. PMID: 5771184, PMCID: PMC322314, DOI: 10.1172/jci106056.Peer-Reviewed Original ResearchConceptsSodium excretionRenal tissueProximal tubular absorptionExcretion of sodiumHealthy nephronsPopulation of nephronsRenal insufficiencyRenal ablationRenal failureTubular absorptionRenal massesSodium balanceGlomerular filtrationDistal tubulesExcretionNephronOsmotic loadEarly adjustmentStepwise increaseMechanisms of changeTissueUninephrectomyHyperfiltrationInsufficiencyRats