1998
Indinavir nephropathy in an AIDS patient with renal insufficiency and pyuria.
Perazella M, Kashgarian M, Cooney E. Indinavir nephropathy in an AIDS patient with renal insufficiency and pyuria. Clinical Nephrology 1998, 50: 194-6. PMID: 9776425.Peer-Reviewed Original ResearchConceptsRenal biopsy findingsRenal insufficiencyBiopsy findingsMild renal insufficiencyAcute renal failureIndinavir crystalsIndinavir therapyRenal failureAntiretroviral agentsUrinary obstructionAIDS patientsCellular castsPatientsPyuriaInsufficiencyRecent reportsSmall percentDiscontinuationNephropathyMedicationsSecond caseDiuresisNephrolithiasisIndinavirObstruction
1993
Transport defects of rabbit medullary thick ascending limb cells in obstructive nephropathy.
Hwang S, Haas M, Harris H, Silva P, Yalla S, Sullivan M, Otuechere G, Kashgarian M, Zeidel M. Transport defects of rabbit medullary thick ascending limb cells in obstructive nephropathy. Journal Of Clinical Investigation 1993, 91: 21-28. PMID: 8380811, PMCID: PMC329990, DOI: 10.1172/jci116173.Peer-Reviewed Original ResearchConceptsMedullary thick ascending limbNa-K-ATPase activityNa-K-ATPaseBasolateral Na-K-ATPaseObstructed kidneysObstructive nephropathyUreteral obstructionLuminal NaRelease of obstructionThick ascending limbMajor sodium transportersUntreated kidneysTransport defectSpecific monoclonal antibodiesSodium transport defectsControl animalsAscending limbOuter medullaKidneyApical NaMarked reductionMonoclonal antibodiesMTAL cellsInhibitory effectObstruction
1977
Renal cortical blood flow distribution in obstructive nephropathy in rats.
Siegel N, Feldman R, Lytton B, Hayslett J, Kashgarian M. Renal cortical blood flow distribution in obstructive nephropathy in rats. Circulation Research 1977, 40: 379-384. PMID: 844151, DOI: 10.1161/01.res.40.4.379.Peer-Reviewed Original ResearchConceptsCortical blood flow distributionBilateral ureteral occlusionUnilateral ureteral occlusionRenal blood flowGlomerular filtration rateOuter cortical perfusionBlood flow distributionCortical perfusionObstructive nephropathyUreteral occlusionRenal cortical blood flow distributionRelease of obstructionIntrarenal hemodynamicsCortical ischemiaUUO ratsRapid normalizationFiltration ratePostobstructive diuresisBlood flowComplete returnRapid returnObstructionRatsNormal patternNephropathy