1989
Metabolic alterations in proximal tubule suspensions obtained from ischemic kidneys
Gaudio K, Thulin G, Ardito T, Kashgarian M, Siegel N. Metabolic alterations in proximal tubule suspensions obtained from ischemic kidneys. American Journal Of Physiology 1989, 257: f383-f389. PMID: 2551186, DOI: 10.1152/ajprenal.1989.257.3.f383.Peer-Reviewed Original ResearchConceptsProximal tubule suspensionsIschemic injuryTubule suspensionsRenal artery ischemiaVivo ischemic injurySprague-Dawley ratsMin of reflowOxygen consumptionPresence of ouabainBasal O2 consumptionArtery ischemiaIschemic kidneyHistopathological appearanceMetabolic alterationsProximal tubulesControl levelsProtein 1
1980
Enhanced recovery from acute renal failure by the postischemic infusion of adenine nucleotides and magnesium chloride in rats
Siegel N, Glazier W, Chaudry I, Gaudio K, Lytton B, Baue A, Kashgarian M. Enhanced recovery from acute renal failure by the postischemic infusion of adenine nucleotides and magnesium chloride in rats. Kidney International 1980, 17: 338-349. PMID: 7401453, DOI: 10.1038/ki.1980.39.Peer-Reviewed Original ResearchConceptsAcute renal failureRenal injuryRenal failureAcute renal injuryIschemic renal injuryAdenine nucleotidesFocal cellular necrosisElevated FENaRenal insultIschemic kidneyIschemic periodTubular functionAcute insultNonischemic kidneysPostischemic infusionFunctional impairmentTubular cellsDegree of improvementCellular necrosisRatsInfusionCINUltrastructural changesUltrastructural studyFENa