1994
Activation of heat-shock transcription factor by graded reductions in renal ATP, in vivo, in the rat.
Van Why S, Mann A, Thulin G, Zhu X, Kashgarian M, Siegel N. Activation of heat-shock transcription factor by graded reductions in renal ATP, in vivo, in the rat. Journal Of Clinical Investigation 1994, 94: 1518-1523. PMID: 7929828, PMCID: PMC295298, DOI: 10.1172/jci117492.Peer-Reviewed Original ResearchConceptsRenal cortexHsp-70 mRNA inductionCortical ATP levelsRenal ischemia resultsPartial aortic occlusionActivation of HSFATP levelsCellular ATPHSF activationHSP-70 mRNAReduction of ATPAortic occlusionPreocclusion levelsProfound fallTotal occlusionIschemia resultsPreocclusion valuesHeat shock transcription factorLow-level expressionMetabolic consequencesVivo 31P NMR spectroscopyControl valuesHSP-70Vigorous responseRenal ATP
1988
Metabolic and functional consequences of inhibiting adenosine deaminase during renal ischemia in rats.
Stromski M, van Waarde A, Avison M, Thulin G, Gaudio K, Kashgarian M, Shulman R, Siegel N. Metabolic and functional consequences of inhibiting adenosine deaminase during renal ischemia in rats. Journal Of Clinical Investigation 1988, 82: 1694-1699. PMID: 3263396, PMCID: PMC442739, DOI: 10.1172/jci113782.Peer-Reviewed Original ResearchConceptsPostischemic restorationFunctional recoveryBilateral renal artery occlusionAdenosine deaminaseResidual nucleotide poolRenal artery occlusionEnd of ischemiaMin of ischemiaMin of reflowArtery occlusionAdenine nucleotide poolPostischemic recoveryRenal ischemiaNucleotide poolIschemia resultsUntreated animalsDegradation of ATPIschemiaBasal levelsRenal ATPATP levelsInitial recoveryRatsInsultFunctional consequences