1990
Morphological and physiological responses to aldosterone: time course and sodium dependence
Wade J, Stanton B, Field M, Kashgarian M, Giebisch G. Morphological and physiological responses to aldosterone: time course and sodium dependence. American Journal Of Physiology 1990, 259: f88-f94. PMID: 2375395, DOI: 10.1152/ajprenal.1990.259.1.f88.Peer-Reviewed Original ResearchConceptsOsmotic minipumpsMale Sprague-Dawley ratsPrincipal cellsElevated aldosterone levelsSprague-Dawley ratsImplanted osmotic minipumpsTime courseBasolateral membraneAldosterone levelsIntravenous infusionAldosterone treatmentPhysiological elevationReplacement infusionsAldosteroneAcute exposureChronic exposureDetectable proliferationFurther elevationDays of exposureSodium dependenceBasolateral membrane areaMinipumpsInfusionSecretionExposure
1984
HEMODYNAMIC EFFECT OF POST-ISCHEMIC ATP-MGCL2
Gaudio K, Thulin G, Kashgarian M, Siegel N. HEMODYNAMIC EFFECT OF POST-ISCHEMIC ATP-MGCL2. Pediatric Research 1984, 18: 362-362. DOI: 10.1203/00006450-198404001-01613.Peer-Reviewed Original ResearchRenal blood flowHemodynamic effectsATP-MgCl2Normal salineBlood flowInitial hemodynamic effectsAcute renal failureInfusion of dopamineRenal failureRenal ischemiaPostischemic infusionInulin clearanceVasoactive compoundsTubular cellsSalutary effectsCINInfusionHrDopamineCellular metabolismIschemiaInjuryRatsSalineClearance
1980
ISCHEMIC ACUTE RENAL FAILURE: DELAYED INFUSION OF ATP-MGCL2
Siegel N, Taylor M, Gaudio K, Chaudry I, Kashgarian M. ISCHEMIC ACUTE RENAL FAILURE: DELAYED INFUSION OF ATP-MGCL2. Pediatric Research 1980, 14: 1017-1017. DOI: 10.1203/00006450-198008000-00262.Peer-Reviewed Original ResearchMinutes of ischemiaATP-MgCl2Normal salineIschemic insultBilateral renal artery occlusionModerate ischemic insultRenal artery occlusionInfusion of ATPDelayed infusionRenal injuryArtery occlusionIschemic injuryRenal ischemiaInitial injuryInitial insultInulin clearanceInjuryIschemiaInfusionInsultCINAnimalsMinutesHoursPrevious studiesEnhanced recovery from acute renal failure by the postischemic infusion of adenine nucleotides and magnesium chloride in rats
Siegel N, Glazier W, Chaudry I, Gaudio K, Lytton B, Baue A, Kashgarian M. Enhanced recovery from acute renal failure by the postischemic infusion of adenine nucleotides and magnesium chloride in rats. Kidney International 1980, 17: 338-349. PMID: 7401453, DOI: 10.1038/ki.1980.39.Peer-Reviewed Original ResearchConceptsAcute renal failureRenal injuryRenal failureAcute renal injuryIschemic renal injuryAdenine nucleotidesFocal cellular necrosisElevated FENaRenal insultIschemic kidneyIschemic periodTubular functionAcute insultNonischemic kidneysPostischemic infusionFunctional impairmentTubular cellsDegree of improvementCellular necrosisRatsInfusionCINUltrastructural changesUltrastructural studyFENa
1975
Effect of lithium on water and electrolyte metabolism.
Galla J, Forrest J, Hecht B, Kashgarian M, Hayslett J. Effect of lithium on water and electrolyte metabolism. The Yale Journal Of Biology And Medicine 1975, 48: 305-14. PMID: 1202760, PMCID: PMC2595176.Peer-Reviewed Original ResearchConceptsEffects of lithiumElectrolyte transportSame nephron segmentsAction of vasopressinChronic administrationOral intakeLithium administrationIntravenous infusionPlasma levelsPotassium secretionElectrolyte metabolismMaximum urineCorticomedullary gradientUrinary acidificationNephron segmentsSustained increaseDistal portionAdministrationNatriuresisInfusionRatsVasopressinIntakeNephronSecretion
1967
Changes in Proximal and Distal Tubular Reabsorption Produced by Rapid Expansion of Extracellular Fluid*
Hayslett J, Kashgarian M, Epstein F. Changes in Proximal and Distal Tubular Reabsorption Produced by Rapid Expansion of Extracellular Fluid*. Journal Of Clinical Investigation 1967, 46: 1254-1263. PMID: 6027087, PMCID: PMC297124, DOI: 10.1172/jci105618.Peer-Reviewed Original ResearchConceptsTubular reabsorptionTubular diameterDistal tubular reabsorptionGlomerular filtration rateProximal tubular reabsorptionAdministration of aldosteroneLoop of HenleAcute infusionFiltration rateRenal contentSaline infusionGlomerular filtrationSegments of tubulesIsotonic salineProximal tubulesExcretion of saltTubular flowReabsorptionExtracellular fluidInfusionTubulesInterstitial volumeRatsTransit timeAldosterone