2020
B cell-intrinsic TLR9 expression is protective in murine lupus
Tilstra JS, John S, Gordon RA, Leibler C, Kashgarian M, Bastacky S, Nickerson KM, Shlomchik MJ. B cell-intrinsic TLR9 expression is protective in murine lupus. Journal Of Clinical Investigation 2020, 130: 3172-3187. PMID: 32191633, PMCID: PMC7260024, DOI: 10.1172/jci132328.Peer-Reviewed Original ResearchConceptsToll-like receptor 9Systemic lupus erythematosusTLR9 deficiencyTLR9 expressionDendritic cellsB cellsPlasmacytoid dendritic cellsAnti-nucleosome antibodiesLupus erythematosusAutoantibody productionMurine lupusSLE pathogenesisTLR9 signalsReceptor 9Cell type-specific effectsType-specific effectsDisease pathogenesisTherapeutic potentialSelective deletionDiseaseNonredundant roleNephritisLupusPathogenesisDeficiency
2008
Disruption of Myosin 1e Promotes Podocyte Injury
Krendel M, Kim SV, Willinger T, Wang T, Kashgarian M, Flavell RA, Mooseker MS. Disruption of Myosin 1e Promotes Podocyte Injury. Journal Of The American Society Of Nephrology 2008, 20: 86-94. PMID: 19005011, PMCID: PMC2615733, DOI: 10.1681/asn.2007111172.Peer-Reviewed Original ResearchConceptsChronic renal injuryNormal glomerular filtrationGlomerular basement membraneRenal injuryKidney inflammationPodocyte foot processesGlomerular diseasePodocyte injuryGlomerular filtrationRenal tissueFoot processesPodocyte functionBasement membraneInjuryUltrastructural levelDiseaseMiceType IProteinuriaInflammationKidneyImportant rolePodocytes
1995
Heat-insoluble cryoglobulin in a patient with essential type I cryoglobulinemia and massive cryoglobulin-occlusive glomerulonephritis
Ishimura E, Nishizawa Y, Shoji S, Okumura M, Nishitani H, Kim C, Watanabe Y, Wakasa K, Morii H, Kashgarian M. Heat-insoluble cryoglobulin in a patient with essential type I cryoglobulinemia and massive cryoglobulin-occlusive glomerulonephritis. American Journal Of Kidney Diseases 1995, 26: 654-657. PMID: 7573022, DOI: 10.1016/0272-6386(95)90604-5.Peer-Reviewed Original ResearchConceptsEnd-stage renal failureMonoclonal IgG-kappaType I cryoglobulinemiaOnset of diseaseElectron-dense depositsEssential cryoglobulinemiaRenal failureClinical courseRenal biopsyNephrotic syndromeIgG kappaLower extremitiesCryoglobulinsGelatinous appearanceGlomerular capillariesCryoglobulinemiaGlomerulonephritisInitial onsetBiopsyDiseaseOnsetYears
1992
The pathobiology of the mesangium
Kashgarian M, Sterzel R. The pathobiology of the mesangium. Kidney International 1992, 41: 524-529. PMID: 1573822, DOI: 10.1038/ki.1992.74.Peer-Reviewed Original ResearchConceptsGlomerular diseaseAdvanced glomerular lesionsProgressive glomerular diseaseGlomerular capillary tuftDiabetic nephropathyIgA nephropathyMesangiocapillary glomerulonephritisGlomerular lesionsHistologic abnormalitiesGlomerular morphologySegmental glomerulosclerosisChronic diseasesSclerotic responseProliferative responseEpithelial cell layerMesangial matrixMesangial cellsCapillary tuftMesangiumDiseaseNephropathyCell layerObvious involvementPathobiologyMammalian kidney
1986
A Review of Nephrotic Syndrome Associated With Chronic Lymphocytic Leukemia
Seney F, Federgreen W, Stein H, Kashgarian M. A Review of Nephrotic Syndrome Associated With Chronic Lymphocytic Leukemia. JAMA Internal Medicine 1986, 146: 137-141. PMID: 3942445, DOI: 10.1001/archinte.1986.00360130167023.Peer-Reviewed Original ResearchConceptsChronic lymphocytic leukemiaNephrotic syndromeLymphocytic leukemiaNephrotic Syndrome AssociatedCommon glomerular lesionImmune complex diseaseRenal diseaseMembranoproliferative glomerulonephritisCellular immunitySyndrome AssociatedGlomerular lesionsImmunoglobulin productionPatientsAvailable evidenceSyndromeLeukemiaDiseaseGlomerulonephritisLesionsImmunity
1985
Pathology of Small Blood Vessel Disease in Hypertension
Kashgarian M. Pathology of Small Blood Vessel Disease in Hypertension. American Journal Of Kidney Diseases 1985, 5: a104-a110. PMID: 2581443, DOI: 10.1016/s0272-6386(85)80072-x.Peer-Reviewed Original ResearchConceptsHyaline arteriolosclerosisPerpetuation of hypertensionSmall blood vessel diseaseBlood vessel diseasesArteriolar diseaseMyointimal hyperplasiaVessel diseasePathogenic rolePathophysiologic consequencesAnatomic correlatesHypertensionTransmural pressureArteriolosclerosisLesionsDiseaseExtracellular matrixArteriolonecrosisHyperplasiaArteriolesPathogenesisTherapyPathologyLyme arthritis. Spirochetes found in synovial microangiopathic lesions.
Johnston Y, Duray P, Steere A, Kashgarian M, Buza J, Malawista S, Askenase P. Lyme arthritis. Spirochetes found in synovial microangiopathic lesions. American Journal Of Pathology 1985, 118: 26-34. PMID: 3966535, PMCID: PMC1887850.Peer-Reviewed Original ResearchConceptsDieterle silver stainObliterative microvascular lesionsSynovial cell hyperplasiaMicroangiopathic lesionsProminent microvasculatureSynovial stromaMicrovascular injuryMicrovascular lesionsVillous hypertrophySynovial specimensCell hyperplasiaSynovial diseaseEndarteritis obliteransLymphoplasmacellular infiltrationStriking depositionNeedle biopsyStromal depositionLyme spirocheteLyme diseaseBlood vesselsPatientsSilver stainLesionsDiseaseSpirochetes
1980
Activation of the Classic Complement Pathway in Patients with the C3 Nephritic Factor
McLean R, Siegel N, Kashgarian M. Activation of the Classic Complement Pathway in Patients with the C3 Nephritic Factor. Nephron 1980, 25: 57-64. PMID: 6986570, DOI: 10.1159/000181754.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBasement MembraneBiopsyCapillariesChildComplement ActivationComplement C3 Nephritic FactorComplement Inactivator ProteinsComplement Pathway, ClassicalFemaleFluorescent Antibody TechniqueGlomerulonephritisHemolysisHumansImmunoelectrophoresis, Two-DimensionalKidneyLipodystrophyMagnesiumMaleMicroscopy, ElectronConceptsC3 nephritic factorNephritic factorPartial lipodystrophyClassic complement pathwayDense deposit diseaseDense intramembranous depositsRenal diseaseDeposit diseaseIntramembranous depositsPatientsFactor assaysComplement pathwayComplement componentsUltrastructural evidenceCurrent criteriaLipodystrophyDiseaseType IHemolytic assayMCGNAssays
1974
Clinical spectrum of postpartum renal failure
Finkelstein F, Kashgarian M, Hayslett J. Clinical spectrum of postpartum renal failure. The American Journal Of Medicine 1974, 57: 649-654. PMID: 4432867, DOI: 10.1016/0002-9343(74)90019-9.Peer-Reviewed Original ResearchConceptsPostpartum renal failureRenal failureFibrin depositionExtensive fibrin depositionFulminant renal failureMinor renal dysfunctionRenal functional abnormalitiesSpectrum of diseaseRenal dysfunctionFatal courseClinical spectrumPostpartum periodRenal abnormalitiesRenal vasculatureFunctional abnormalitiesPatientsAbnormalitiesFailureDysfunctionDiseaseVasculatureMinimal Change and Focal Sclerotic Lesions in Lipoid Nephrosis
Siegel N, Kashgarian M, Spargo B, Hayslett J. Minimal Change and Focal Sclerotic Lesions in Lipoid Nephrosis. Nephron 1974, 13: 125-137. PMID: 4368918, DOI: 10.1159/000180385.Peer-Reviewed Original ResearchConceptsSteroid-sensitive diseaseFocal sclerotic lesionsNephrotic syndromeSclerotic lesionsMinimal change lesionCourse of diseaseMinimal glomerular changesYears of ageLipoid nephrosisSteroid resistanceClinicopathological relationshipRenal biopsyGlomerular changesFocal glomerulosclerosisUltrastructural examinationDiseaseLesionsSyndromeChildrenLight microscopyMinimal changesOnsetEarly evidenceYearsBroad spectrum
1972
CLINICOPATHOLOGICAL CORRELATIONS OF PRIMARY HÆMATURIA
Hendler E, Kashgarian M, Hayslett J. CLINICOPATHOLOGICAL CORRELATIONS OF PRIMARY HÆMATURIA. The Lancet 1972, 299: 458-463. PMID: 4109816, DOI: 10.1016/s0140-6736(72)90121-3.Peer-Reviewed Original ResearchConceptsRenal diseaseProliferative glomerulonephritisPathological lesionsMild proliferative glomerulonephritisUrinary tract lesionsUrinary protein excretionGroup of patientsTypes of glomerulonephritisSevere proliferative glomerulonephritisType of lesionIntercurrent infectionRenal functionRenal biopsyProtein excretionPrimary lesionClinicopathological correlationDistribution of ageCorrect diagnosisPatientsGlomerulonephritisLesionsYoung adultsDiseaseHæmorrhageUseful index
1969
Progression of Lipoid Nephrosis to Renal Insufficiency
Hayslett J, Krassner L, Bensch K, Kashgarian M, Epstein F. Progression of Lipoid Nephrosis to Renal Insufficiency. New England Journal Of Medicine 1969, 281: 181-187. PMID: 5790494, DOI: 10.1056/nejm196907242810402.Peer-Reviewed Original Research