2021
International consensus to standardise histopathological scoring for small bowel strictures in Crohn’s disease
Gordon I, Bettenworth D, Bokemeyer A, Srivastava A, Rosty C, de Hertogh G, Robert M, Valasek M, Mao R, Li J, Harpaz N, Borralho P, Pai R, Odze R, Feakins R, Parker C, Guizzetti L, Nguyen T, Shackelton L, Sandborn W, Jairath V, Baker M, Bruining D, Fletcher J, Feagan B, Pai R, Rieder F. International consensus to standardise histopathological scoring for small bowel strictures in Crohn’s disease. Gut 2021, 71: 479-486. PMID: 33952604, PMCID: PMC8903083, DOI: 10.1136/gutjnl-2021-324374.Peer-Reviewed Original ResearchConceptsSmall bowel stricturesMucosal inflammatory diseasesBowel stricturesCrohn's diseaseHistopathological scoring systemScoring systemInflammatory diseasesIncreased bowel wall thicknessCrypt architectural distortionIntact surface epitheliumSurgically resected specimensPyloric gland metaplasiaSmall bowel Crohn's diseaseEffective medical therapyLos Angeles methodologyPaneth cell hyperplasiaBowel wall thicknessBasal lymphoplasmacytosisAnastomotic strictureMedical therapyStricture diseaseCell hyperplasiaClinical trial efficiencyNeutrophilic inflammationLymphoid aggregates
2019
Histopathology Scoring Systems of Stenosis Associated With Small Bowel Crohn’s Disease: A Systematic Review
Gordon IO, Bettenworth D, Bokemeyer A, Srivastava A, Rosty C, de Hertogh G, Robert ME, Valasek MA, Mao R, Kurada S, Harpaz N, Borralho P, Pai RK, Pai RK, Odze R, Feakins R, Parker CE, Nguyen T, Jairath V, Baker ME, Bruining DH, Fletcher JG, Feagan BG, Rieder F, Consortium S. Histopathology Scoring Systems of Stenosis Associated With Small Bowel Crohn’s Disease: A Systematic Review. Gastroenterology 2019, 158: 137-150.e1. PMID: 31476299, PMCID: PMC7649049, DOI: 10.1053/j.gastro.2019.08.033.Peer-Reviewed Original ResearchConceptsSmall bowel Crohn's diseaseCrohn's diseaseSystematic reviewScoring systemFibromuscular stenosisComputed tomography enterographyMEDLINE of studiesEffective medical therapyCross-sectional imaging techniquesStudy of patientsHistologic scoring systemSemiquantitative histologic evaluationSame scoring systemImportant pathologic componentHistopathology indexSymptomatic stricturesTomography enterographyCommon complicationMedical therapyResection specimenHistologic findingsAntifibrotic agentsFibrotic alterationsHistologic evaluationHistopathologic grading
1996
Rectal afferent function in patients with inflammatory and functional intestinal disorders
Bernstein C, Niazi N, Robert M, Mertz H, Kodner A, Munakata J, Naliboff B, Mayer E. Rectal afferent function in patients with inflammatory and functional intestinal disorders. Pain 1996, 66: 151-161. PMID: 8880836, DOI: 10.1016/0304-3959(96)03062-x.Peer-Reviewed Original ResearchConceptsIrritable bowel syndromeInflammatory bowel diseaseDiarrhea-predominant irritable bowel syndromeViscerosomatic referral patternCrohn's disease patientsIBS patientsDisease patientsCrohn's diseaseMale patientsReferral patternsAfferent pathwaysReflex responsesHealthy male control subjectsTissue irritationAutonomic reflex responsesChronic ileal inflammationLower distension pressuresRapid phasic distensionDorsal horn neuronsVisceral afferent pathwaysIleal Crohn's diseaseFunctional intestinal disordersMale control subjectsSkin conductance responsesBulbospinal inhibition
1993
Rectal substance P concentrations are increased in ulcerative colitis but not in Crohn's disease.
Bernstein C, Robert M, Eysselein V. Rectal substance P concentrations are increased in ulcerative colitis but not in Crohn's disease. The American Journal Of Gastroenterology 1993, 88: 908-13. PMID: 7684884.Peer-Reviewed Original ResearchConceptsSubstance P concentrationsSubstance P levelsCrohn's diseaseUlcerative colitisSubstance PIncreasing concentrations of substance PConcentrations of substance PPathogenesis of ulcerative colitisRectal mucosal biopsiesNon-inflammatory bowel disease patientsMucosal neutrophilsUC patientsMucosal levelMucosal biopsiesCD patientsAffected patientsIncreased inflammationInflammatory cellsRectal diseaseColonic mucosaInflammatory processPatientsDisease patientsBiopsyMotor phenomena