2015
ENPP1-Fc prevents mortality and vascular calcifications in rodent model of generalized arterial calcification of infancy
Albright RA, Stabach P, Cao W, Kavanagh D, Mullen I, Braddock AA, Covo MS, Tehan M, Yang G, Cheng Z, Bouchard K, Yu ZX, Thorn S, Wang X, Folta-Stogniew EJ, Negrete A, Sinusas AJ, Shiloach J, Zubal G, Madri JA, De La Cruz EM, Braddock DT. ENPP1-Fc prevents mortality and vascular calcifications in rodent model of generalized arterial calcification of infancy. Nature Communications 2015, 6: 10006. PMID: 26624227, PMCID: PMC4686714, DOI: 10.1038/ncomms10006.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseVascular calcificationArterial calcificationOrphan diseaseCommon diseaseSequelae of diseaseEctopic vascular calcificationInternal elastic laminaPrevent mortalityRenal failureCardiac failureKidney diseaseSubcutaneous administrationRodent modelsAnimal modelsEctopic calcificationVascular wallLarge arteriesElastic laminaDiseaseCalcificationCalciphylaxisDecreased concentrationSclerosisArtery
2009
Strain Differences in Behavioral and Cellular Responses to Perinatal Hypoxia and Relationships to Neural Stem Cell Survival and Self-Renewal Modeling the Neurovascular Niche
Li Q, Liu J, Michaud M, Schwartz ML, Madri JA. Strain Differences in Behavioral and Cellular Responses to Perinatal Hypoxia and Relationships to Neural Stem Cell Survival and Self-Renewal Modeling the Neurovascular Niche. American Journal Of Pathology 2009, 175: 2133-2145. PMID: 19815710, PMCID: PMC2774076, DOI: 10.2353/ajpath.2009.090354.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBehavior, AnimalCell DifferentiationCell MovementCell SurvivalCells, CulturedChemokine CXCL12Endothelial CellsEnzyme ActivationFemaleHumansHypoxiaHypoxia-Inducible Factor 1, alpha SubunitHypoxia-Inducible Factor-Proline DioxygenasesInfantInfant, NewbornInfant, PrematureMaleMiceMice, Inbred C57BLMice, Inbred StrainsNeuronsNeuropsychological TestsPhosphatidylinositol 3-KinasesProcollagen-Proline DioxygenaseProto-Oncogene Proteins c-aktSignal TransductionStem CellsConceptsChronic hypoxiaC57 miceHIF-1alphaLow birth weight infant populationMatrix metalloproteinase-9 activityStromal-derived factor-1CD-1 miceMetalloproteinase-9 activityAdult C57 miceHypoxia-induced factorNeural stem cell survivalHigher apoptosis ratePerinatal hypoxiaRepair/recoveryClinical improvementNeurodevelopmental handicapPreventive therapyPremature infantsNeurogenic zonesNeurovascular nicheInfant populationC57BL/6 pupsProlyl hydroxylase domain 2Migratory responsivenessStem cell survivalModeling the neurovascular niche: implications for recovery from CNS injury.
Madri JA. Modeling the neurovascular niche: implications for recovery from CNS injury. Journal Of Physiology And Pharmacology 2009, 60 Suppl 4: 95-104. PMID: 20083857.Peer-Reviewed Original ResearchConceptsNeurovascular nicheCNS injuryHIF-1alphaSpinal cord injuryNeural stem cell survivalNeurogenic zonesCord injuryTraumatic brainMurine modelSDF-1Sublethal hypoxiaInjuryStem cell survivalNRP-1Neurodegenerative diseasesEndothelial cellsHypoxiaExpression levelsSurvivalCell survivalFocused reviewDiseaseVariable responseTrkBBDNFUsing proteomics in perinatal and neonatal sepsis: hopes and challenges for the future
Buhimschi CS, Bhandari V, Han YW, Dulay AT, Baumbusch MA, Madri JA, Buhimschi IA. Using proteomics in perinatal and neonatal sepsis: hopes and challenges for the future. Current Opinion In Infectious Diseases 2009, 22: 235-243. PMID: 19395960, PMCID: PMC2763282, DOI: 10.1097/qco.0b013e32832a5963.Peer-Reviewed Original ResearchConceptsNeonatal sepsisEarly-onset neonatal sepsisInsulin-like growth factor-binding protein-1Growth factor-binding protein-1Proteomic biomarkersAdvanced glycation end productsAmniotic fluid biomarkersAmniotic fluid inflammationFetal immune responsePoor neurodevelopmental outcomesIntra-amniotic infectionRisk of sepsisGlycation end productsHistological chorioamnionitisPreterm birthInflammatory statusNeurodevelopmental outcomesNeuroprotection strategiesInflammatory stateNeurological injuryFluid biomarkersInflammatory processImmune responseAmniotic fluidDefensin 2
2007
Modeling the neurovascular niche: Murine strain differences mimic the range of responses to chronic hypoxia in the premature newborn
Li Q, Michaud M, Stewart W, Schwartz M, Madri JA. Modeling the neurovascular niche: Murine strain differences mimic the range of responses to chronic hypoxia in the premature newborn. Journal Of Neuroscience Research 2007, 86: 1227-1242. PMID: 18092360, PMCID: PMC2644407, DOI: 10.1002/jnr.21597.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornApoptosisBlotting, WesternBrainCell ProliferationDisease Models, AnimalGene ExpressionHematopoiesis, ExtramedullaryHumansHypoxia, BrainImmunohistochemistryImmunoprecipitationInfant, NewbornInfant, PrematureIntercellular Signaling Peptides and ProteinsMiceMice, Inbred C57BLNitric OxideStem CellsConceptsNeural progenitor cellsChronic hypoxiaSubventricular zonePreterm birth resultsLow baseline levelsHypoxia-induced levelsNeurogenic responseNeurovascular nicheHypoxic insultBlunted responseBirth resultsC57BL/6 pupsBaseline levelsMotor disabilityMouse strainsGrowth factorVariable recoveryHypoxiaProgenitor cellsPupsRecent evidenceSignificant cognitiveHypoxicApoptotic responseResponse
1995
Germinal matrix microvascular maturation correlates inversely with the risk period for neonatal intraventricular hemorrhage
Ment L, Stewart W, Ardito T, Madri J. Germinal matrix microvascular maturation correlates inversely with the risk period for neonatal intraventricular hemorrhage. Brain Research 1995, 84: 142-149. PMID: 7720213, DOI: 10.1016/0165-3806(94)00168-y.Peer-Reviewed Original ResearchConceptsNeonatal intraventricular hemorrhageIntraventricular hemorrhagePostnatal dayRisk periodDay 1Blood-brain barrierNewborn beagle pupsTenth postnatal dayEndothelial cell areaBasal lamina depositionPerinatal inductionPreterm neonatesBasement membrane areaWeeks' gestationGestational agePostnatal ageGerminal matrixBeagle pupsElectron microscopic examinationLuminal areaTight junction lengthWhite matterDay 10Time pointsBeagle model
1989
Dispase, a Neutral Protease From Bacillus Polymyxa, Is a Powerful Fibronectinase and Type IV Collagenase
Stenn K, Link R, Moellmann G, Madri J, Kuklinska E. Dispase, a Neutral Protease From Bacillus Polymyxa, Is a Powerful Fibronectinase and Type IV Collagenase. Journal Of Investigative Dermatology 1989, 93: 287-290. PMID: 2546994, DOI: 10.1111/1523-1747.ep12277593.Peer-Reviewed Original Research
1980
The collagenous components of the subendothelium. Correlation of structure and function.
Madri J, Dreyer B, Pitlick F, Furthmayr H. The collagenous components of the subendothelium. Correlation of structure and function. Laboratory Investigation 1980, 43: 303-15. PMID: 7003251.Peer-Reviewed Original ResearchConceptsCell surfaceEndothelial cell surfaceEndothelial cellsSpecific immunoprecipitation techniquesBiosynthetic incorporationImmunofluorescence microscopyImmunoelectron microscopyImmunoprecipitation techniquesAB2 collagenCellsCollagenous componentsAggregation occursCorrelation of structureCollagen typesImportant roleMonolayer of endotheliumCollagenPlatelet adhesionPlatelet aggregationImportant determinantNonthrombogenic surfaceVascular wallTreesType IVAdhesion