1993
Prognostic significance of K-ras mutations in colorectal carcinoma
Benhattar J, Losi L, Chaubert P, Givel J, Costa J. Prognostic significance of K-ras mutations in colorectal carcinoma. Gastroenterology 1993, 104: 1044-1048. PMID: 8462792, DOI: 10.1016/0016-5085(93)90272-e.Peer-Reviewed Original ResearchConceptsK-ras mutationsPrognostic significanceColorectal carcinomaK-ras geneRecurrent diseaseCodon 12Good prognostic factorAdvanced colorectal carcinomaPossible prognostic significanceHuman colorectal carcinomaPolymerase chain reaction-based techniquesDukes' BPrognostic factorsColorectal cancerPrimary tumorOverall prevalenceHigh riskPatientsRas mutationsCarcinomaHuman tumorsTumorsDiseasePrevalenceGGT
1992
Stability of K-ras mutations throughout the natural history of human colorectal cancer
Losi L, Benhattar J, Costa J. Stability of K-ras mutations throughout the natural history of human colorectal cancer. European Journal Of Cancer 1992, 28: 1115-1120. PMID: 1627381, DOI: 10.1016/0959-8049(92)90468-h.Peer-Reviewed Original ResearchConceptsK-ras mutationsPrimary tumorRas mutationsNatural historyColorectal cancerTumor markersStable tumor markerHuman colorectal cancerDistant recurrenceRecurrent cancerRecurrent tumorsPolymerase chain reactionColorectal carcinomaCodon 12TumorsArchival tissueCancerChain reactionAllele-specific amplificationPatientsRecurrenceMarkersMutationsCarcinomaDisease
1991
Alveolar soft-part sarcoma of the uterine corpus: Histological, immunocytochemical and ultrastructural study of a case
Guillou L, Lamoureux E, Masse S, Costa J. Alveolar soft-part sarcoma of the uterine corpus: Histological, immunocytochemical and ultrastructural study of a case. Virchows Archiv A Pathological Anatomy And Histopathology 1991, 418: 467-471. PMID: 2035261, DOI: 10.1007/bf01605935.Peer-Reviewed Original ResearchConceptsAlveolar soft part sarcomaSoft part sarcomaUterine corpusHMB-45 antibodyEvidence of diseaseNK1/C3Hysterectomy specimenClinical managementIncidental findingDifferential diagnosisElectron microscopic examinationTumor cellsSarcomaMicroscopic examinationCytoplasmic granulesUltrastructural studyPatientsImmunoreactivityCytokeratinCrystalloidsDiseaseDiagnosisVimentinDesminAntibodies
1988
The Pathological Staging of Sarcomas
Costa J, Leyvraz S. The Pathological Staging of Sarcomas. Developments In Oncology 1988, 18-21. DOI: 10.1007/978-94-009-2691-2_4.Peer-Reviewed Original Research
1980
Advanced ovarian cancer correlation of histologic grade with response to therapy and survival
Ozols R, Garvin A, Costa J, Simon R, Young R. Advanced ovarian cancer correlation of histologic grade with response to therapy and survival. Cancer 1980, 45: 572-581. PMID: 7353206, DOI: 10.1002/1097-0142(19800201)45:3<572::aid-cncr2820450325>3.0.co;2-3.Peer-Reviewed Original ResearchConceptsHistologic gradeStage IIIGrade 4 patientsAdvanced ovarian cancerGrade 1 patientsProspective clinical trialsSurvival of patientsChoice of chemotherapyDegree of anaplasiaDifferent survival outcomesEfficacy of chemotherapyAdvanced diseaseCombination chemotherapyProspective studySurvival outcomesCytologic gradeClinical trialsOvarian cancerStratification factorsChemotherapyPatientsGrade 2Therapeutic importanceDiseaseSurvival