1995
PEC‐A: An immortalized porcine aortic endothelial cell
Khodadoust M, Candal F, Maher S, Murray A, Pober J, Davis W, Ades E, Bothwell A. PEC‐A: An immortalized porcine aortic endothelial cell. Xenotransplantation 1995, 2: 79-87. DOI: 10.1111/j.1399-3089.1995.tb00070.x.Peer-Reviewed Original ResearchAortic endothelial cellsCultured porcine aortic endotheliumNormal aortic endothelial cellsSignificant T-cell proliferative responsesMHC class II antigensT cell proliferative responsesEndothelial cellsClass IPorcine aortic endotheliumClass II antigensClass II expressionImmortalized porcine aortic endothelial cellsExpression of CD44Porcine aortic endothelial cellsCell surface antigensVon Willebrand factorPorcine ECII antigensT cellsProliferative responseHuman CD4Aortic endotheliumSurface antigenEndothelial responseAcetylated LDL
1994
Antigen-presenting function of human endothelial cells. Direct activation of resting CD8 T cells.
Epperson DE, Pober JS. Antigen-presenting function of human endothelial cells. Direct activation of resting CD8 T cells. The Journal Of Immunology 1994, 153: 5402-12. PMID: 7989746, DOI: 10.4049/jimmunol.153.12.5402.Peer-Reviewed Original ResearchConceptsCD8 T cellsMemory CD8 T cellsT cell proliferative responsesAllogeneic endothelial cellsCell proliferative responsesT cellsAdhesion molecule-1Endothelial cellsCD8/IL-2Proliferative responseMolecule-1CD4 T cell proliferative responsesLate activation Ag-4Human CD8 T cellsVascular cell adhesion molecule-1Class II MHC expressionIntercellular adhesion molecule-1Cell adhesion molecule-1CD4 T cellsIFN-gamma secretionOrgan graft rejectionIL-2R alpha subunitIntercellular adhesion molecule-2CD8 cells
1985
Human dermal fibroblasts present tetanus toxoid antigen to antigen-specific T cell clones.
Umetsu DT, Pober JS, Jabara HH, Fiers W, Yunis EJ, Burakoff SJ, Reiss CS, Geha RS. Human dermal fibroblasts present tetanus toxoid antigen to antigen-specific T cell clones. Journal Of Clinical Investigation 1985, 76: 254-260. PMID: 3160726, PMCID: PMC423759, DOI: 10.1172/jci111955.Peer-Reviewed Original ResearchConceptsAntigen-presenting cellsTetanus toxoidProliferative responseClassical antigen-presenting cellsAntigen-specific proliferative responsesAntigen-specific T cell clonesHLA-DR antigensHelper T cellsTetanus toxoid antigenT cell proliferationT cell clonesHuman dermal fibroblastsPresent tetanus toxoidMonoclonal antibody OKM1Cultured human dermal fibroblastsDermal fibroblastsLeu-M1DR expressionHLA-DRUbiquitous cell typeAntigen presentationT cellsToxoid antigenSephadex G10 columnImmune interferon