2021
ZFYVE21 is a Mediator of Non-Canonical Hedgehog Signaling Activating NLRP3 Inflammasomes in a Pathologic Subset of CD4+PD-1hi T Cells
Jiang B, Fang C, Soh C, Li X, Geirsson A, Tellides G, Pober J, Jane-Wit D. ZFYVE21 is a Mediator of Non-Canonical Hedgehog Signaling Activating NLRP3 Inflammasomes in a Pathologic Subset of CD4+PD-1hi T Cells. The Journal Of Heart And Lung Transplantation 2021, 40: s136. DOI: 10.1016/j.healun.2021.01.422.Peer-Reviewed Original ResearchT cellsNLRP3 inflammasomeEndothelial cellsDelayed graft functionSubset of CD4Humanized mouse modelComplement-mediated injuryNLRP3 inflammasome activityHuman lymphoid cellsNon-canonical Hedgehog signallingNon-canonical hedgehogGraft functionPeripheral injuryMemory CD4Human endothelial cellsPD-1Injury showCellular immunityVascular injuryChemokine receptorsTissue injuryPrimary human endothelial cellsInflammasome activityMouse modelLymphoid cells
1989
Functions of vascular wall cells related to development of transplantation-associated coronary arteriosclerosis.
Libby P, Salomon RN, Payne DD, Schoen FJ, Pober JS. Functions of vascular wall cells related to development of transplantation-associated coronary arteriosclerosis. Transplantation Proceedings 1989, 21: 3677-84. PMID: 2669279.Peer-Reviewed Original ResearchConceptsArterial diseaseT cellsVascular cellsChronic immune reactionsTransplantation-associated arteriosclerosisTypical acute rejectionDelayed-type hypersensitivityHelper T cellsWall cellsClass II HLACytolytic T cellsVascular wall cellsClass I HLAVessel wall cellsUnderstanding of atherogenesisAcute rejectionGraft arteryCoronary arteriosclerosisCoronary atherosclerosisBasic pathobiologyCellular immunityImmune activationSelective therapeutic strategiesCoronary circulationAccelerated disease