2020
Tumor necrosis factor receptor‐2 signaling pathways promote survival of cancer stem‐like CD133+ cells in clear cell renal carcinoma
Bradley JR, Wang J, Pacey S, Warren AY, Pober JS, Al‐Lamki R. Tumor necrosis factor receptor‐2 signaling pathways promote survival of cancer stem‐like CD133+ cells in clear cell renal carcinoma. FASEB BioAdvances 2020, 2: 126-144. PMID: 32123862, PMCID: PMC7003657, DOI: 10.1096/fba.2019-00071.Peer-Reviewed Original ResearchCancer stem-like cellsClear cell renal cell carcinomaCell survivalPromotes cell survivalCytochrome c releaseCell cycle entryMitochondrial morphological changesPI-3KTumor necrosis factor receptor 2Kinase cascadePhosphorylation of VEGFR2Stem-like cellsC releaseReactive oxygen speciesZ-VADCycle entrySignal transducerTranscription 3Cell cycleNecrostatin-1Cell deathClear cell renal carcinomaSiRNA knockdownMixed lineageCell renal cell carcinoma
1996
"Cytosolic" phospholipase A2 is in the nucleus of subconfluent endothelial cells but confined to the cytoplasm of confluent endothelial cells and redistributes to the nuclear envelope and cell junctions upon histamine stimulation.
Sierra-Honigmann MR, Bradley JR, Pober JS. "Cytosolic" phospholipase A2 is in the nucleus of subconfluent endothelial cells but confined to the cytoplasm of confluent endothelial cells and redistributes to the nuclear envelope and cell junctions upon histamine stimulation. Laboratory Investigation 1996, 74: 684-95. PMID: 8600319.Peer-Reviewed Original ResearchConceptsSubconfluent endothelial cellsConfluent endothelial cellsNuclear envelopeNuclear localizationConfocal immunofluorescence microscopyEndothelial cellsDose-dependent redistributionGrowth-arrested cellsSubcellular localizationCell density dependencePlasma membraneCell cycleCytoplasmic enzymeNuclear extractsCell junctionsPhospholipase A2 enzymeBovine endothelial cellsHeLa cellsImmunofluorescence microscopyCell lysatesCell nucleiIntercellular junctionsSubconfluent cellsPredominant MrAcid metabolism