2020
Lysis of cold‐storage‐induced microvascular obstructions for ex vivo revitalization of marginal human kidneys
DiRito JR, Hosgood SA, Reschke M, Albert C, Bracaglia LG, Ferdinand JR, Stewart BJ, Edwards CM, Vaish AG, Thiru S, Mulligan DC, Haakinson DJ, Clatworthy MR, Saltzman WM, Pober JS, Nicholson ML, Tietjen GT. Lysis of cold‐storage‐induced microvascular obstructions for ex vivo revitalization of marginal human kidneys. American Journal Of Transplantation 2020, 21: 161-173. PMID: 32627324, PMCID: PMC7775334, DOI: 10.1111/ajt.16148.Peer-Reviewed Original ResearchConceptsNormothermic machine perfusionHuman kidneyMicrovascular obstructionMarginal organsHigh-risk donorsSevere organ shortageLikelihood of complicationsMicrovascular blood flowAccumulation of fibrinogenCold storage injuryTissue plasminogen activatorImmediate translational potentialMicrovascular pluggingRenal functionRenal injuryMachine perfusionTubular epitheliumBlood flowIntravascular releaseOrgan shortagePhysiologic impactKidneyTranslational potentialPlasminogen activatorVivo assessment
2008
Chapter 2 Physiology and Pathobiology of Microvascular Endothelium
Pober J. Chapter 2 Physiology and Pathobiology of Microvascular Endothelium. 2008, 37-55. DOI: 10.1016/b978-0-12-374530-9.00002-4.Peer-Reviewed Original ResearchMicrovascular ECsVascular ECsRegulation of inflammationType II activationEarly activation eventsPlastic cell typeCell typesEndothelial dysfunctionInflammatory processAdaptive immunityChapter 2 PhysiologyBlood flowMicrovascular endotheliumVascular endotheliumBlood fluidityInflammation processEpithelial-like cellsHost defenseInflammationEntire circulatory systemCirculatory systemDysfunctionInjuryEndotheliumBlood