2020
The role of survivin in the progression of pancreatic ductal adenocarcinoma (PDAC) and a novel survivin-targeted therapeutic for PDAC
Brown M, Zhang W, Yan D, Kenath R, Le L, Wang H, Delitto D, Ostrov D, Robertson K, Liu C, Pham K. The role of survivin in the progression of pancreatic ductal adenocarcinoma (PDAC) and a novel survivin-targeted therapeutic for PDAC. PLOS ONE 2020, 15: e0226917. PMID: 31929540, PMCID: PMC6957139, DOI: 10.1371/journal.pone.0226917.Peer-Reviewed Original ResearchConceptsPancreatic ductal adenocarcinomaTypes of cancerDuctal adenocarcinomaSurvivin expressionSurvivin inhibitorClinical response rateNovel survivin inhibitorHalf of patientsElevated survivin expressionLower patient survivalPancreatic tumor microenvironmentPotential therapeutic targetExpression of survivinRole of survivinField of oncologyPancreatic cancer linesImmunotherapeutic approachesPatient survivalUntreated cohortTherapeutic responseInhibitor of survivinTreatment resistancePDAC progressionEffective treatmentTumor cell migration
2012
Heterogeneity in signaling pathways of gastroenteropancreatic neuroendocrine tumors: a critical look at notch signaling pathway
Wang H, Chen Y, Castillo C, Yilmaz O, Deshpande V. Heterogeneity in signaling pathways of gastroenteropancreatic neuroendocrine tumors: a critical look at notch signaling pathway. Modern Pathology 2012, 26: 139-147. PMID: 22918166, DOI: 10.1038/modpathol.2012.143.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkers, TumorHumansImmunohistochemistryIntestinal NeoplasmsNeuroendocrine TumorsOligonucleotide Array Sequence AnalysisPancreatic NeoplasmsReal-Time Polymerase Chain ReactionReceptors, NotchRectal NeoplasmsReverse Transcriptase Polymerase Chain ReactionSignal TransductionTissue Array AnalysisTranscriptomeConceptsRectal neuroendocrine tumorsGastroenteropancreatic neuroendocrine tumorsIleal neuroendocrine tumorsNeuroendocrine tumorsPancreatic neuroendocrine tumorsClinical trialsISL LIM homeobox 1Tryptophan hydroxylase 1Quantitative reverse transcription PCRReverse transcription-PCRGene profiling studiesNotch1 inhibitorTissue microarrayImmunohistochemical analysisMolecular pathogenesisTumorsLIM homeobox 1Endocrine pathwaysGene expression profilingGlobal gene expression profilingHomeobox 1Gene profiling resultsNotch1Further studiesProliferation pathways