2012
SEC23B is required for the maintenance of murine professional secretory tissues
Tao J, Zhu M, Wang H, Afelik S, Vasievich M, Chen X, Zhu G, Jensen J, Ginsburg D, Zhang B. SEC23B is required for the maintenance of murine professional secretory tissues. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: e2001-e2009. PMID: 22745161, PMCID: PMC3406820, DOI: 10.1073/pnas.1209207109.Peer-Reviewed Original ResearchMeSH KeywordsAlcian BlueAnimalsAnthraquinonesApoptosisEndoplasmic ReticulumFluorescent Antibody TechniqueHumansIn Situ Nick-End LabelingMiceMice, Inbred C57BLMice, TransgenicMicroscopy, ImmunoelectronMutationPancreasReal-Time Polymerase Chain ReactionSecretory PathwaySpecies SpecificityVesicular Transport ProteinsConceptsEndoplasmic reticulumSecretory tissueSpecies-specific shiftsGTPase-activating proteinsUnfolded protein responseAccumulation of proteinsSimilar ultrastructural alterationsAbundant cargoCargo recognitionEukaryotic cellsSar1 GTPaseER exitER lumenSecretory pathwayTissue-specific dependenceProtein responseHypomorphic mutationsSecretory proteinsSEC23BDisparate phenotypesCOPIICongenital dyserythropoietic anemia type IIEmbryonic pancreasAnemia phenotypeProapoptotic pathways
2008
Transgenic overexpression of a stable Plasminogen Activator Inhibitor-1 variant
Fahim A, Wang H, Feng J, Ginsburg D. Transgenic overexpression of a stable Plasminogen Activator Inhibitor-1 variant. Thrombosis Research 2008, 123: 785-792. PMID: 18774162, PMCID: PMC2670886, DOI: 10.1016/j.thromres.2008.07.004.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsLungMiceMice, TransgenicMutationPlasminogen Activator Inhibitor 1RNA, MessengerTransgenesConceptsPlasminogen activator inhibitor-1Plasma PAI-1 levelsPAI-1 levelsPAI-1 mRNAHigher plasma PAI-1 levelsTransgenic overexpressionEvidence of thrombosisActivator inhibitor-1PAI-1 variantsApparent thrombosisHistologic examinationSerine protease inhibitor gene familyPhysiologic effectsTransgenic miceChicken beta-actin promoterModerate expressionInhibitor-1High expressionBeta-actin promoterBiologic importanceThrombosisPhysiologic conditionsKidneyMiceLiver