2018
Inflammatory signature in lung tissues in patients with combined pulmonary fibrosis and emphysema
Cornwell WD, Kim C, Lastra AC, Dass C, Bolla S, Wang H, Zhao H, Ramsey FV, Marchetti N, Rogers TJ, Criner GJ. Inflammatory signature in lung tissues in patients with combined pulmonary fibrosis and emphysema. Biomarkers 2018, 24: 232-239. PMID: 30411980, PMCID: PMC6509019, DOI: 10.1080/1354750x.2018.1542458.Peer-Reviewed Original ResearchConceptsInterstitial pulmonary fibrosisInflammatory profilePulmonary fibrosisLung tissueInflammatory proteinDistinct inflammatory profilesCohort of patientsCombined pulmonary fibrosisDistinct inflammatory processesEmphysematous lung tissueInflammatory protein levelsExplanted LungsInflammatory signatureInflammatory processDisease processEmphysemaPatientsEmphysematous tissueFibrosisLungProtein levelsTissue sectionsCPFETissueTissue extracts
2008
Transgenic overexpression of a stable Plasminogen Activator Inhibitor-1 variant
Fahim A, Wang H, Feng J, Ginsburg D. Transgenic overexpression of a stable Plasminogen Activator Inhibitor-1 variant. Thrombosis Research 2008, 123: 785-792. PMID: 18774162, PMCID: PMC2670886, DOI: 10.1016/j.thromres.2008.07.004.Peer-Reviewed Original ResearchConceptsPlasminogen activator inhibitor-1Plasma PAI-1 levelsPAI-1 levelsPAI-1 mRNAHigher plasma PAI-1 levelsTransgenic overexpressionEvidence of thrombosisActivator inhibitor-1PAI-1 variantsApparent thrombosisHistologic examinationSerine protease inhibitor gene familyPhysiologic effectsTransgenic miceChicken beta-actin promoterModerate expressionInhibitor-1High expressionBeta-actin promoterBiologic importanceThrombosisPhysiologic conditionsKidneyMiceLiver