Heterogeneity in signaling pathways of gastroenteropancreatic neuroendocrine tumors: a critical look at notch signaling pathway
Wang H, Chen Y, Castillo C, Yilmaz O, Deshpande V. Heterogeneity in signaling pathways of gastroenteropancreatic neuroendocrine tumors: a critical look at notch signaling pathway. Modern Pathology 2012, 26: 139-147. PMID: 22918166, DOI: 10.1038/modpathol.2012.143.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkers, TumorHumansImmunohistochemistryIntestinal NeoplasmsNeuroendocrine TumorsOligonucleotide Array Sequence AnalysisPancreatic NeoplasmsReal-Time Polymerase Chain ReactionReceptors, NotchRectal NeoplasmsReverse Transcriptase Polymerase Chain ReactionSignal TransductionTissue Array AnalysisTranscriptomeConceptsRectal neuroendocrine tumorsGastroenteropancreatic neuroendocrine tumorsIleal neuroendocrine tumorsNeuroendocrine tumorsPancreatic neuroendocrine tumorsClinical trialsISL LIM homeobox 1Tryptophan hydroxylase 1Quantitative reverse transcription PCRReverse transcription-PCRGene profiling studiesNotch1 inhibitorTissue microarrayImmunohistochemical analysisMolecular pathogenesisTumorsLIM homeobox 1Endocrine pathwaysGene expression profilingGlobal gene expression profilingHomeobox 1Gene profiling resultsNotch1Further studiesProliferation pathwaysSEC23B is required for the maintenance of murine professional secretory tissues
Tao J, Zhu M, Wang H, Afelik S, Vasievich M, Chen X, Zhu G, Jensen J, Ginsburg D, Zhang B. SEC23B is required for the maintenance of murine professional secretory tissues. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: e2001-e2009. PMID: 22745161, PMCID: PMC3406820, DOI: 10.1073/pnas.1209207109.Peer-Reviewed Original ResearchMeSH KeywordsAlcian BlueAnimalsAnthraquinonesApoptosisEndoplasmic ReticulumFluorescent Antibody TechniqueHumansIn Situ Nick-End LabelingMiceMice, Inbred C57BLMice, TransgenicMicroscopy, ImmunoelectronMutationPancreasReal-Time Polymerase Chain ReactionSecretory PathwaySpecies SpecificityVesicular Transport ProteinsConceptsEndoplasmic reticulumSecretory tissueSpecies-specific shiftsGTPase-activating proteinsUnfolded protein responseAccumulation of proteinsSimilar ultrastructural alterationsAbundant cargoCargo recognitionEukaryotic cellsSar1 GTPaseER exitER lumenSecretory pathwayTissue-specific dependenceProtein responseHypomorphic mutationsSecretory proteinsSEC23BDisparate phenotypesCOPIICongenital dyserythropoietic anemia type IIEmbryonic pancreasAnemia phenotypeProapoptotic pathways