2004
Impaired angiogenesis in SHR is associated with decreased KDR and MT1-MMP expression
Wang H, Olszewski B, Rosebury W, Wang D, Robertson A, Keiser J. Impaired angiogenesis in SHR is associated with decreased KDR and MT1-MMP expression. Biochemical And Biophysical Research Communications 2004, 315: 363-368. PMID: 14766216, DOI: 10.1016/j.bbrc.2004.01.059.Peer-Reviewed Original ResearchMeSH KeywordsAdenoviridaeAnimalsCell DivisionDNA, ComplementaryDown-RegulationEnzyme-Linked Immunosorbent AssayGene Transfer TechniquesHumansImmunoblottingImmunohistochemistryMatrix Metalloproteinases, Membrane-AssociatedMetalloendopeptidasesNeovascularization, PathologicProliferating Cell Nuclear AntigenRatsRats, Inbred SHRRats, Inbred WKYRats, Sprague-DawleySignal TransductionSpectrophotometryTime FactorsUp-RegulationVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-2ConceptsSpontaneous hypertensive ratsKinase insert domain-containing receptorMT1-MMP expressionAge-matched normotensive Wistar-KyotoImpaired angiogenesisEndothelial proliferationHypertension animal modelsNormotensive Wistar-KyotoSponge implantation modelLevel of angiogenesisSprague-Dawley ratsVEGF gene transferHypertensive ratsWistar KyotoDomain-containing receptorMembrane type 1 matrix metalloproteinaseAnimal modelsImmunohistological analysisMatrix metalloproteinaseImpaired VEGFSponge implantationAngiogenesisVEGF addition
2000
Hepatocyte Growth Factor Enhances MMP Activity in Human Endothelial Cells
Wang H, Keiser J. Hepatocyte Growth Factor Enhances MMP Activity in Human Endothelial Cells. Biochemical And Biophysical Research Communications 2000, 272: 900-905. PMID: 10860849, DOI: 10.1006/bbrc.2000.2852.Peer-Reviewed Original ResearchMeSH KeywordsCell LineCell MovementCollagenCoronary VesselsDermisDose-Response Relationship, DrugDrug CombinationsEndothelium, VascularEnzyme ActivationEnzyme InductionFlavonoidsHepatocyte Growth FactorHumansLamininMAP Kinase Signaling SystemMatrix Metalloproteinase 2Matrix Metalloproteinase InhibitorsMatrix Metalloproteinases, Membrane-AssociatedMetalloendopeptidasesMitogen-Activated Protein KinasesMolecular WeightPhosphorylationProteoglycansProto-Oncogene Proteins c-metRNA, MessengerConceptsSF/HGFHepatocyte growth factorExtracellular matrixMAP kinase cascadeSignal transduction pathwaysScatter factorMT1-MMP synthesisMatrix metalloproteinasesGrowth factorHuman EC linesKinase cascadeTransduction pathwaysEC invasionHGF stimulationEndothelial cell productionHuman endothelial cellsMMP-2 activationArterial ECsMT1-MMPVessel stabilizationTube formationCurrent studyAngiogenic factorsEC linesMMP activity
1998
Expression of Membrane-Type Matrix Metalloproteinase in Rabbit Neointimal Tissue and Its Correlation with Matrix-Metalloproteinase-2 Activation
Wang H, Keiser J. Expression of Membrane-Type Matrix Metalloproteinase in Rabbit Neointimal Tissue and Its Correlation with Matrix-Metalloproteinase-2 Activation. Journal Of Vascular Research 1998, 35: 45-54. PMID: 9482695, DOI: 10.1159/000025564.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAortaBase SequenceBlotting, NorthernCells, CulturedDNA, ComplementaryEnzyme ActivationGelatinasesGene ExpressionHumansMaleMatrix Metalloproteinase 2Matrix Metalloproteinases, Membrane-AssociatedMetalloendopeptidasesMolecular Sequence DataMuscle, Smooth, VascularPolymerase Chain ReactionRabbitsRNA ProbesRNA, MessengerSequence HomologyConceptsBalloon catheter de-endothelializationMMP-2 activationArterial SMCsTemporal expression patternsMembrane-type matrix metalloproteinasesMembrane-type matrix metalloproteinaseNorthern blot analysisMatrix metalloproteinasesExtracellular matrix degradationRabbit cDNAMammalian cellsMT-MMP-1Matrix metalloproteinase-2 activationMT-MMP-1 expressionExpression patternsVascular neointimal formationSequence analysisMMP-2MMP cDNAPhenotypic alterationsCDNAPeak expressionRNA probesBlot analysisMatrix degradation