2020
The role of survivin in the progression of pancreatic ductal adenocarcinoma (PDAC) and a novel survivin-targeted therapeutic for PDAC
Brown M, Zhang W, Yan D, Kenath R, Le L, Wang H, Delitto D, Ostrov D, Robertson K, Liu C, Pham K. The role of survivin in the progression of pancreatic ductal adenocarcinoma (PDAC) and a novel survivin-targeted therapeutic for PDAC. PLOS ONE 2020, 15: e0226917. PMID: 31929540, PMCID: PMC6957139, DOI: 10.1371/journal.pone.0226917.Peer-Reviewed Original ResearchConceptsPancreatic ductal adenocarcinomaTypes of cancerDuctal adenocarcinomaSurvivin expressionSurvivin inhibitorClinical response rateNovel survivin inhibitorHalf of patientsElevated survivin expressionLower patient survivalPancreatic tumor microenvironmentPotential therapeutic targetExpression of survivinRole of survivinField of oncologyPancreatic cancer linesImmunotherapeutic approachesPatient survivalUntreated cohortTherapeutic responseInhibitor of survivinTreatment resistancePDAC progressionEffective treatmentTumor cell migration
2014
Expression of ERCC1, TYMS, RRM1, TUBB3, non-muscle myosin II, myoglobin and MyoD1 in lung adenocarcinoma pleural effusions predicts survival in patients receiving platinum-based chemotherapy
JIANG H, WANG H, WANG S, PEI Z, FU Z, FANG C, WANG J, LU Q, WANG E, LI J. Expression of ERCC1, TYMS, RRM1, TUBB3, non-muscle myosin II, myoglobin and MyoD1 in lung adenocarcinoma pleural effusions predicts survival in patients receiving platinum-based chemotherapy. Molecular Medicine Reports 2014, 11: 3523-3532. PMID: 25573098, DOI: 10.3892/mmr.2014.3141.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdenocarcinoma of LungAdultAgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsBiomarkers, TumorDNA-Binding ProteinsDrug Resistance, NeoplasmEndonucleasesFemaleGene ExpressionHumansImmunohistochemistryKaplan-Meier EstimateLung NeoplasmsMaleMiddle AgedMyoD ProteinMyoglobinMyosin Type IIPlatinumPleural Effusion, MalignantPrognosisRibonucleoside Diphosphate ReductaseThymidylate SynthaseTubulinTumor Suppressor ProteinsConceptsExcision repair cross-complementing gene 1Expression of ERCC1Platinum-based chemotherapyMetastatic lung adenocarcinomaLung adenocarcinomaPleural effusionLung Adenocarcinoma Pleural EffusionsPlatinum-based chemotherapy treatmentTumor cellsUntreated lung adenocarcinomasSurvival of patientsMalignant pleural effusionPleural fluid samplesExpression levelsProtein expression levelsWestern blot analysisClinical outcomesPatient survivalLung cancerChemotherapy treatmentLung carcinomaNon-muscle myosin IIPatientsAdenocarcinomaSurvival rate