Dose‐Dependent Neovascularization‐Promoting Effect of Adenovirus Vector CI‐1023 in a Rat Hindlimb Ischaemic Model
Wang H, Keiser J, Olszewski B, Brammer D, Gordon D. Dose‐Dependent Neovascularization‐Promoting Effect of Adenovirus Vector CI‐1023 in a Rat Hindlimb Ischaemic Model. Basic & Clinical Pharmacology & Toxicology 2004, 95: 76-80. PMID: 15379784, DOI: 10.1111/j.1742-7843.2004.950206.x.Peer-Reviewed Original ResearchConceptsHindlimb ischemic modelDose-dependent effectIschemic modelObvious dose-dependent effectDose rangeLocal tissue expressionVascular endothelial growth factor (VEGF) proteinReplication-deficient adenovirus vectorLaser Doppler scanningEfficacy of CIWide dose rangeGrowth factor proteinDoppler scanningImmuno-histochemistryTissue blood perfusionBlood perfusionTissue expressionAdenovirus vectorFactor proteinPrevious studiesAngiography