2013
Early B-cell factor 1 is an essential transcription factor for postnatal glomerular maturation
Fretz JA, Nelson T, Velazquez H, Xi Y, Moeckel GW, Horowitz MC. Early B-cell factor 1 is an essential transcription factor for postnatal glomerular maturation. Kidney International 2013, 85: 1091-1102. PMID: 24172684, PMCID: PMC4006322, DOI: 10.1038/ki.2013.433.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAlbuminuriaAnimalsBlood Urea NitrogenCell DifferentiationCells, CulturedGene Expression Regulation, DevelopmentalGenotypeGlomerular Filtration RateKidney GlomerulusMice, 129 StrainMice, Inbred C57BLMice, KnockoutOrganogenesisPhenotypePodocytesSignal TransductionTime FactorsTrans-ActivatorsVascular Endothelial Growth Factor AConceptsEarly B-cell factor 1B cell factor 1Transcription factorsNovel roleTranscription factor early B cell factor 1Expression of Ebf1Essential transcription factorFactor 1Podocyte maturationMesenchymal progenitorsB cell maturationProper maturationBlood urea nitrogen levelsElevated blood urea nitrogen levelsWild-type control miceGlomerular filtration rateVascular endothelial growth factor AGlomerular maturationUrea nitrogen levelsGrowth factor ARenal developmentEBF1Factor AGlomerular developmentNephron maturation
1997
Kidney-targeted liposome-mediated gene transfer in mice
Lai L, Moeckel G, Lien Y. Kidney-targeted liposome-mediated gene transfer in mice. Gene Therapy 1997, 4: 426-431. PMID: 9274719, DOI: 10.1038/sj.gt.3300406.Peer-Reviewed Original ResearchConceptsBlood urea nitrogen levelsUrea nitrogen levelsRenal tubular cellsTubular epithelial cellsGene therapyRenal histologyLeft kidneyArterial injectionArterial groupParenchymal groupTubular cellsGene transferParenchymal injectionOuter medullaD-galactopyranoside stainingKidneyEpithelial cellsInterstitial compartmentCytomegalovirus immediate-early gene promoterInjectionLiposome-mediated gene deliveryTherapyΒ-galactosidase expressionTransient gene transferImmediate-early gene promoter