2014
Role of medullary progenitor cells in epithelial cell migration and proliferation
Chen D, Chen Z, Zhang Y, Park C, Al-Omari A, Moeckel GW. Role of medullary progenitor cells in epithelial cell migration and proliferation. American Journal Of Physiology. Renal Physiology 2014, 307: f64-f74. PMID: 24808539, PMCID: PMC4080159, DOI: 10.1152/ajprenal.00547.2013.Peer-Reviewed Original ResearchConceptsProgenitor cellsEpithelial cell migrationSide populationInterstitial cell lineEpithelial cellsBone marrow-derived stem cellsCell migrationMarrow-derived stem cellsInjury repairMedullary interstitiumDuct cellsInner medullaCell proliferationCell linesProliferationTubule formationStem cellsInterstitial progenitor cellsDifferentiation mediumCellsPhenotypic characteristicsCritical roleIMCD3 cellsPGE2CXCR4
2008
Fibrocystin/Polyductin Modulates Renal Tubular Formation by Regulating Polycystin-2 Expression and Function
Kim I, Fu Y, Hui K, Moeckel G, Mai W, Li C, Liang D, Zhao P, Ma J, Chen XZ, George AL, Coffey RJ, Feng ZP, Wu G. Fibrocystin/Polyductin Modulates Renal Tubular Formation by Regulating Polycystin-2 Expression and Function. Journal Of The American Society Of Nephrology 2008, 19: 455-468. PMID: 18235088, PMCID: PMC2391052, DOI: 10.1681/asn.2007070770.Peer-Reviewed Original ResearchConceptsFibrocystin/polyductinPC2 channel activityRenal cystic phenotypeGene-targeted mutationPolycystic kidney diseaseCultured renal epithelial cellsAutosomal recessive polycystic kidney diseaseHuman autosomal recessive polycystic kidney diseaseCommon molecular pathwaysEpithelial cellsRecessive polycystic kidney diseaseRenal epithelial cellsAberrant ciliogenesisKidney diseasePolycystin-2Polycystin-2 expressionPrimary ciliaCystic phenotypeSingle mutationMolecular pathwaysGenetic modifiersPhenotypic characteristicsMutationsMolecular interactionsAutosomal dominant polycystic kidney disease