2020
Paracrine orchestration of intestinal tumorigenesis by a mesenchymal niche
Roulis M, Kaklamanos A, Schernthanner M, Bielecki P, Zhao J, Kaffe E, Frommelt LS, Qu R, Knapp MS, Henriques A, Chalkidi N, Koliaraki V, Jiao J, Brewer JR, Bacher M, Blackburn HN, Zhao X, Breyer RM, Aidinis V, Jain D, Su B, Herschman HR, Kluger Y, Kollias G, Flavell RA. Paracrine orchestration of intestinal tumorigenesis by a mesenchymal niche. Nature 2020, 580: 524-529. PMID: 32322056, PMCID: PMC7490650, DOI: 10.1038/s41586-020-2166-3.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsAntigens, LyArachidonic AcidCarcinogenesisCell Cycle ProteinsCell ProliferationColorectal NeoplasmsCyclooxygenase 2DinoprostoneFemaleFibroblastsHumansIntestinal MucosaIntestinesMaleMembrane ProteinsMesodermMiceNeoplastic Stem CellsOrganoidsParacrine CommunicationReceptors, Prostaglandin E, EP4 SubtypeSingle-Cell AnalysisStem Cell NicheYAP-Signaling ProteinsConceptsSingle-cell RNA-sequencing analysisTumor-initiating stem cellsRNA sequence analysisMesenchymal nicheStem cellsTumor initiationSca-1Hippo pathway effector YAPStem cell functionCell expansionPathway effector YAPMutant stem cellsEpithelial-specific ablationIntestinal stem cellsEarly tumor initiationProstaglandin E2Regenerative reprogrammingNormal epithelial stem cellsParacrine controlTumorigenic programsNiche modelsNuclear localizationTranscriptional activityYAP dephosphorylationEpithelial stem cells
2018
Gastric Adenocarcinoma of the Fundic Gland Type
Benedict MA, Lauwers GY, Jain D. Gastric Adenocarcinoma of the Fundic Gland Type. American Journal Of Clinical Pathology 2018, 149: 461-473. PMID: 29648578, DOI: 10.1093/ajcp/aqy019.Peer-Reviewed Original ResearchConceptsFundic gland typeGA-FGGastric adenocarcinomaParietal cellsEndoscopic mucosal resectionGeneral surgical pathologistsFeatures of malignancyChief cell differentiationGland typeDeeper invasionExtragastric spreadGastric atrophyLymphovascular invasionBenign courseIntestinal metaplasiaMucosal resectionNodal metastasisSurgical excisionChronic gastritisRare lesionsUncommon neoplasmHelicobacter infectionOxyntic mucosaSurgical pathologistsAdequate treatment