2017
Bile acids initiate cholestatic liver injury by triggering a hepatocyte-specific inflammatory response
Cai SY, Ouyang X, Chen Y, Soroka CJ, Wang J, Mennone A, Wang Y, Mehal WZ, Jain D, Boyer JL. Bile acids initiate cholestatic liver injury by triggering a hepatocyte-specific inflammatory response. JCI Insight 2017, 2: e90780. PMID: 28289714, PMCID: PMC5333973, DOI: 10.1172/jci.insight.90780.Peer-Reviewed Original ResearchConceptsLiver injuryInflammatory responseBile acid-induced liver injuryCholestatic liver injuryInflammatory liver injuryProinflammatory cytokine expressionCholestatic liver diseaseBile duct ligationVivo mouse modelHepatic infiltrationInflammatory injurySerum aminotransferasesLiver diseaseCholestatic patientsCytokine expressionChemokine inductionPathophysiologic concentrationsNeutrophil chemotaxisDuct ligationPathophysiologic levelsMouse modelNew therapiesInnate immunityInjuryPeriportal areas
2008
Colchicine-associated Ring Mitosis in Liver Biopsy and Their Clinical Implications
Kamath A, Mehal W, Jain D. Colchicine-associated Ring Mitosis in Liver Biopsy and Their Clinical Implications. Journal Of Clinical Gastroenterology 2008, 42: 1060-1062. PMID: 18391833, PMCID: PMC3730132, DOI: 10.1097/mcg.0b013e31803815b4.Peer-Reviewed Original ResearchConceptsChronic hepatitis CLiver biopsyHepatitis CColchicine toxicityMultiorgan failureLiver injuryHistopathologic manifestationsTissue injuryGastrointestinal tractMedical conditionsBiopsyClinical implicationsSalivary glandsInjuryAntimitotic activityMitosesColchicineToxicityTransfusionHistopathologicGoutYearsKidneyLiverTract