2022
Microangiopathic Hemolytic Anemia Is a Late and Fatal Complication of Gastric Signet Ring Cell Carcinoma: A Systematic Review and Case-Control Study
Lam R, Tarangelo N, Wang R, Horibe M, Grimshaw AA, Jain D, Haffar S, Bazerbachi F, Kunz PL, Li DK. Microangiopathic Hemolytic Anemia Is a Late and Fatal Complication of Gastric Signet Ring Cell Carcinoma: A Systematic Review and Case-Control Study. The Oncologist 2022, 27: 751-759. PMID: 35589098, PMCID: PMC9438916, DOI: 10.1093/oncolo/oyac093.Peer-Reviewed Original ResearchConceptsGastric signet ring cell carcinomaSignet ring cell carcinomaMicroangiopathic hemolytic anemiaHemolytic anemiaCell carcinomaMultivariable Cox proportional hazards regression modelingCox proportional hazards regression modelingSystematic reviewRare paraneoplastic syndromeStage-matched casesEnd Results (SEER) databaseLate-stage complicationsRisk of mortalityCase-control studyBone painParaneoplastic syndromeFatal complicationMedian survivalMetastatic diseaseOverall survivalLymph nodesIndex presentationPrognostic featuresResults databasePooled cohortAn Appraisal of Immunohistochemical Stain Use in Hepatic Metastasis Highlights the Effectiveness of the Individualized, Case-Based Approach: Analysis of Data From a Tertiary Care Medical Center.
Wang JD, Sebastian C, Walther Z, Suresh T, Lacy J, Zhang X, Jain D. An Appraisal of Immunohistochemical Stain Use in Hepatic Metastasis Highlights the Effectiveness of the Individualized, Case-Based Approach: Analysis of Data From a Tertiary Care Medical Center. Archives Of Pathology & Laboratory Medicine 2022, 147: 185-192. PMID: 35512224, DOI: 10.5858/arpa.2021-0457-oa.Peer-Reviewed Original ResearchConceptsLiver biopsyUnknown primaryIHC markersPrimary siteTrue carcinomaTertiary care medical centerAvailable clinicopathologic dataSquamous cell carcinomaClinicopathologic dataHepatic metastasesNonepithelial tumorsCell carcinomaInstitutional databaseClinical managementStain usePractice patternsNeuroendocrine neoplasmsImmunohistochemical markersMedical CenterMorphologic patternsIndividualized approachCarcinomaBiopsyMetastasisTumors
2020
Updates in staging and pathologic evaluation of esophageal carcinoma following neoadjuvant therapy
Zhang X, Jain D. Updates in staging and pathologic evaluation of esophageal carcinoma following neoadjuvant therapy. Annals Of The New York Academy Of Sciences 2020, 1482: 163-176. PMID: 32892349, DOI: 10.1111/nyas.14462.Peer-Reviewed Original ResearchConceptsNeoadjuvant therapyEsophageal cancerEsophageal carcinomaRecent American Joint CommitteePreoperative neoadjuvant therapyThorough pathologic assessmentTumor regression gradingAdvanced esophageal carcinomaAmerican Joint CommitteeCancer (AJCC) staging systemTumor regression gradeAccurate tumor stagingValuable prognostic informationRegression gradingSurgical resectionLymph nodesPathologic assessmentRegression gradeHistologic typePathologic evaluationResidual tumorPoor prognosisCell carcinomaGastrointestinal carcinomasStaging system
2015
Recurrence of Merkel cell carcinoma in the gastrointestinal tract: a case report
Tuktamyshov R, Jain D, Ginsburg PM. Recurrence of Merkel cell carcinoma in the gastrointestinal tract: a case report. BMC Research Notes 2015, 8: 188. PMID: 25947008, PMCID: PMC4430924, DOI: 10.1186/s13104-015-1139-3.Peer-Reviewed Original ResearchConceptsMerkel cell carcinomaCell carcinomaGastrointestinal tractYear old Caucasian femaleEvaluation of anemiaAggressive skin malignancyOld Caucasian femaleIron deficiency anemiaBackgroundMerkel cell carcinomaPrimary neural cellsRegional lymphLocal recurrenceCase presentationWeSkin malignanciesCase reportCaucasian femaleCarcinomaRecurrenceNeural cellsTractAnemiaMetastasisDistant historyLymphColonoscopy
2009
Lack of Immunohistochemical Detection of VEGF in Prostate Carcinoma
Kamath A, Helie M, Bifulco CB, Li WW, Concato J, Jain D. Lack of Immunohistochemical Detection of VEGF in Prostate Carcinoma. Applied Immunohistochemistry & Molecular Morphology 2009, 17: 227-232. PMID: 19098681, DOI: 10.1097/pai.0b013e31818f9e7f.Peer-Reviewed Original ResearchConceptsVascular endothelial growth factorVEGF expressionBenign glandsMalignant glandsDifferent antigen retrieval techniquesVeterans Health Administration hospitalsEndothelial cellsBenign prostatic hyperplasiaRenal cell carcinomaDifferent antibodiesNonspecific stainingPotential therapeutic targetEndothelial growth factorCell carcinomaProstatic hyperplasiaAntigen retrieval methodAntigen retrieval techniqueFibromuscular stromaAdministration HospitalBreast carcinomaProstatic adenocarcinomaHepatocellular carcinomaProstate carcinomaStudy populationIHC analysis
2000
Epstein-Barr virus RNA detection and glandular differentiation in nasopharyngeal carcinoma: report of 2 cases.
Jain D, Parkash V, Li M, Gill J, Crouch J, Howe G, Tallini G. Epstein-Barr virus RNA detection and glandular differentiation in nasopharyngeal carcinoma: report of 2 cases. Archives Of Pathology & Laboratory Medicine 2000, 124: 1369-72. PMID: 10975941, DOI: 10.5858/2000-124-1369-ebvrda.Peer-Reviewed Original ResearchConceptsGlandular differentiationNasopharyngeal typeUndifferentiated carcinomaEpstein-Barr virus latent membrane proteinEpstein-Barr virus genomeSquamous cell carcinomaLatent membrane proteinVirus RNA detectionCell carcinomaMost tumorsNasopharyngeal carcinomaCarcinomaTumorsRNA detectionUndifferentiated areasNasopharynxSitu hybridizationVirus genomeLight microscopyDifferentiationImmunohistochemistryPositivity