Placenta Research

Articles, chapters, abstracts, and patents regarding Placental Research.
  1. Soto EA, Kliman HJ, Strauss JF III and Paavola L. (1986) Gonadotrophin-induced changes in morphology of human granulosa cells in culture. Biol Reprod 34: 559-569.
  2. Kliman HJ, Nestler JE, Sermasi E, Sanger JM, and Strauss JF III. (1986) Purification, characterization and in vitro differentiation of cytotrophoblasts from human term placentae. Endocrinol. 118: 1567-1582.
  3. Feinman MA, Kliman HJ, Caltabiano S, and Strauss JF III. (1986) 8-Bromo-3'5' AMP stimulates the endocrine activity of human cytotrophoblasts in culture. J Clin End Metab 63: 1211-1217.
  4. Ulloa-Aguirre A., August AM, Golos, TG, Kao L-C, Sukuragi N, Kliman HJ, and Strauss, JF III (1987). 8-Bromo-3'5' adenosine monophosphate regulates expression of chorionic gonadotropin and fibronectin in human cytotrophoblasts. J. Clin. End. Metab., 64: 1002-1009.
  5. Feinman MA, Kliman HJ, and Main EK. (1987) HLA antigen-expression and induction by gamma-interferon in cultured trophoblasts. Am. J. Obstet. Gynecol. 157: 1429-34.
  6. Kliman HJ, Feinman MA and Strauss JF III. (1987) Differentiation of human cytotrophoblasts into syncytiotrophoblasts in culture. Trophoblast Research 2: 407-421.
  7. Roy-Choudhury, S., Sen-Majumdar A., Murthy U, Mishra VS, Kliman HJ, Nestler JE, Strauss JF III, and Das M. (1988). Biosynthesis and turnover of a 34,000 molecular weight protein growth factor in human cytotrophoblasts. Eur J. Biochem. 172: 777-783.
  8. Kao L-C, Caltabiano S, Wu S, Strauss JF III, Kliman HJ. (1988) The human villous cytotrophoblast: Interaction with extracellular matrix proteins, endocrine function, and cytoplasmic differentiation in the absence of syncytium formation. Developmental Biol. 130: 693-702.
  9. Nulsen, JC, Silavin S. L, Kao L-C, Ringler GE, Kliman HJ, and Strauss JF III (1989) Control of the steroidogenic machinery of the human trophoblasts by cyclic AMP. J. Reprod Fert, Suppl., 37: 147-153.
  10. Kliman HJ, Coutifaris C, Babalola GO, Soto EA, Kao L-C, Queenan JT, Feinberg RF, Strauss JF III. (1989) The human trophoblast: Homotypic and heterotypic cell-cell interactions. Prog. Clin. Biol. Res. 294: 425-34.
  11. Feinberg RF, Kao L-C, Haimowitz JE, Queenan JT Jr, Wun T-C Strauss JF III, Kliman HJ. (1989) Plasminogen activator inhibitors types 1 and 2 in human trophoblasts: PAI-1 is a marker of invading trophoblasts. Laboratory Investigation, 61: 20-26.
  12. Babalola, GO, Coutifaris C, Soto EA, Kliman HJ, Shuman H, Strauss JF III. (1990) Aggregation of dispersed human cytotrophoblastic cells: lessons relevant to the morphogenesis of the placenta. Developmental Biology, 137: 100-108.
  13. Kliman HJ, Feinberg RF. (1990) Human trophoblast-extracellular matrix (ECM) interactions in vitro: ECM thickness modulates morphology and proteolytic activity. Proc Natl Acad Sci U S A, 87:3057-3061.
  14. Kliman HJ, Feinberg RF, Haimowitz JE. (1990) Interactions between human term trophoblasts and endometrium in vitro. Colloques INSERM, 199: 3-9.
  15. Kliman HJ, Feinberg RF, Haimowitz JE. (1990) Human trophoblast-endometrial interactions in an in vitro suspension culture system. Placenta, 11:349-367.
  16. Kliman HJ. (1990) Three steps to knowledge. Surgical Pathology, 3:161.
  17. Feinberg RF, Kliman HJ, Lockwood CJ. (1991) Oncofetal fibronectin: A trophoblast "glue" for human implantation? Am J Pathology, 138:537-543.
  18. Kliman HJ, Strauss JF III, Kao L-C, Caltabiano S, Wu S. (1991) Cytoplasmic and biochemical differentiation of the human villous cytotrophoblast in the absence of syncytium formation. Trophoblast Research 5:297-309.
  19. Feinberg RF, Kliman HJ, Cohen AW (1991) Preeclampsia, trisomy 13, and the placental bed. Obstet Gynecol 78:505-8.
  20. Coutifaris C, Babalola GO, Abisogun AO, Kao LC, Chin U, Vadillo OF, Osheroff J, Kliman HJ, Strauss JF3 (1991) In vitro systems for the study of human trophoblast implantation. Ann N Y Acad Sci 622:191-201.
  21. Feinberg RF, Kliman HJ (1992) Fetal fibronectin and preterm labor [letter]. N Engl J Med 326:708; discussion 709.
  22. Kliman HJ. (1993) The placenta revealed. Am J Path 143:332-336.
  23. Feinberg RF, Kliman HJ. (1993) Tropho-uteronectin (TUN): A unique oncofetal fibronectin deposited in the extracellular matrix of the tropho-uterine junction and regulated in vitro by cultured human trophoblasts. Trophoblast Research 7:167-179.
  24. Feinberg RF, Kliman HJ, Wang CL. (1994) Transforming growth factor beta (TGFß) stimulates tropho-uteronectin (TUN) synthesis in vitro: Implications for trophoblast implantation in vivo. J Clin Endocrinology Metabolism 78:1241-48.
  25. Rotmensch S, Liberati M, Juo J-S, Kliman HJ, Gollin Y, Bellati U, Hobbins JC, Copel JA. (1994) Color Doppler flow patterns and flow velocity wave forms of the intraplacental fetal circulation in growth-retarded fetuses. Am J Obstet Gynecol 171:1257-64.
  26. Feinberg RF, Kliman HJ, Bedian V, Monzon-Bordonaba F, Menzin AW, Wang C-L. (1995) Monoclonal antibody X18A4 identifies an oncofetal fibronectin epitope distinct from the FDC-6 binding site. Am J Obstet Gynecol 172:1526-36.
  27. Bahado-Singh RO, Kliman H, Feng TY, Hobbins J, Copel JA, Mahoney MJ. (1995) First-trimester endocervical irrigation: feasibility of obtaining trophoblast cells for prenatal diagnosis. Obstet Gynecol 85:461-4.
  28. Kliman HJ, Perrotta P, Jones D. (1995) The efficacy of the placental biopsy. Am J Ob Gyn 173:1084-8.
  29. Nachtigall MJ, Kliman HJ, Feinberg RF, Meaddough EL, Arici A. (1996) The effect of leukemia inhibitory factor (LIF) on trophoblast differentiation: A potential role in human implantation. J Clin Endo Met 81:801-6.
  30. Kliman HJ. (2000) Uteroplacental blood flow: The story of decidualization, menstruation and trophoblast invasion. Am J Pathol 157:1759-68.
  31. Kliman HJ, Segel L. (2003) The placenta may predict the baby. J Ther Biol, 225: 143-145 (pdf).
  32. Rejniak KA, Kliman HJ, Fauci LJ. (2004) A computational model of the mechanics of growth of the villous trophoblast bilayer. Bull Math Biol, 66:199-23.
  33. Than NG, Pick E, Bellyei S, Szigeti A, Burger O, Berente Z, Janaky T, Boronkai A, Kliman HJ, Meiri H, Bohn H, Than GN, Sumegi B. (2004) Functional analyses ofplacental protein 13/galectin-13. Eur J Biochem, 271:1065-1078.
  34. Anderson GM, Jacobs-Stannard A, Chawarska K, Volkmar FR, Kliman HJ. Placental Trophoblast Inclusions in Autism Spectrum Disorder, Biological Psychiatry, June 22, 2006
  35. Hecht JL, Kliman HJ, Allred EN, Pflueger SM, Chang CH, Doss BJ, Roberts D, Livasy CA, Bhan I, Zambrano E, Ross DW, Senagore P, Husain AN, Leviton A. (2007) Reference Weights for Placentas Delivered before the 28th Week of Gestation. Placenta, 28:987-90.
  36. Hecht JL, Onderdonk A, Delaney M, Allred EN, Kliman HJ, Zambrano E, Pflueger SM, Livasy CA, Bhan I, Leviton A. (2008) ELGAN Study Investigators. Characterization of chorioamnionitis in 2nd-trimester C-section placentas and correlation with microorganism recovery from subamniotic tissues. Pediatric & Developmental Pathology, 11:15-22.
  37. Hecht JL, Allred EN, Kliman HJ, Zambrano E, Doss BJ, Husain A, Pflueger SM, Chang CH, Livasy CA, Roberts D, Bhan I, Ross DW, Senagore PK, Leviton A, Elgan Study Investigators. (2008) Histological characteristics of singleton placentas delivered before the 28th week of gestation. Pathology, 40:372-6.
  38. Yusuf K, Kliman HJ. (2008) The fetus, not the mother, elicits maternal immunologic rejection: lessons from discordant dizygotic twin placentas. J Perinat Med, 36:291-296.
  39. Funai EF, Labowsky AT, Drewes CE, Kliman HJ. (2009) Timing of Fetal Meconium Absorption by Amnionic Macrophages. Am J Perinatology, 26:93-7.
  40. Lash GE, Ansari T, Bischof P, Burton GJ, Chamley L, Crocker I, Dantzer V, Desoye G, Drewlo S, Fazleabas A, Jansson T, Keating S, Kliman HJ, Lang I, Mayhew T, Meiri H, Miller RK, Nelson DM, Pfarrer C, Roberts C, Sammar M, Sharma S, Shiverick K, Strunk D, Turner MA, Huppertz B 2009 IFPA meeting 2008 workshops report. Placenta 30 Suppl A:S4-14.
  41. Azpurua HJ, Funai EF, Coraluzzi L, Sasson I, Doherty L, Kliman M, Kliman HJ. (2010) Determination of placental weight using two-dimensional sonography and volumetric mathematic modeling, Am J Perinatology, 27:151-155.
  42. Kliman HJ, Sammar M, Gimpel Y, Lynch SK, Milano SK, Pick E, Bejar J, Arad A, Lee JJ, Meiri H, Gonen R. (2012) Placental protein 13 and decidual zones of necrosis: an immunologic diversion that may be linked to preeclampsia. Reproductive Sciences, 19:12-26.
  43. Trivedi S, Joachim M, McElrath T, Kliman HJ, Allred EN, Fichorova RN, Onderdonk A, Heitor F, Chaychi L, Leviton A, Majzoub JA (2012) Fetal-placental inflammation, but not adrenal activation, is associated with extreme preterm delivery. Am J Obstet Gynecol, 206:236e1-e8.
  44. Walker CK, Anderson KW, Milano KM, Ye S, Tancredi DJ, Pessah IN, Hertz-Picciotto I, Kliman HJ. (2013) Trophoblast Inclusions are Significantly Increased in the Placentas of Children in Families at Risk for Autism, Biological Psychiatry, 74:204-211
  45. Arleo EK, Troiano RN, da Silva R, Greenbaum D, Kliman HJ. Utilizing 2-Dimensional Ultrasound to Develop Normative Curves for Estimated Placental Volume (EPV). Am J Perinatology. 2013 Oct 9. [Epub ahead of print]
  46. Kliman, HJ. (2014) Comment on “The placenta harbors a unique microbiome.” Sci Transl Med, 6(254):254le4
  47. Stephenson MD, McQueen D, Desjardins MD, Kliman HJ. (2016) Vaginal micronized progesterone started in the luteal phase improves live birth rate in women with recurrent pregnancy loss. Fertility and Sterility, online release
  48. Salvante KG, Milano K, Kliman HJ and Nepomnaschy PA. (2017) Placental 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) expression very early during human pregnancy. Journal of Developmental Origins of Health and Disease, 8(2), pp. 149–154. doi: 10.1017/S2040174416000611
  49. Sonek J, Krantz D, Carmichael J, Downing C, Jessup K, Haidar Z, Ho S, Hallahan T, Kliman HJ, McKenna D. (2018) First trimester screening for early and late preeclampsia using maternal characteristics, biomarkers, and estimated placental volume. American Journal of Obstetrics & Gynecology,  218:126.e1-126.e13; doi: 10.1016/j.ajog.2017.10.024
  50. Isakov KMM, Emerson JW, Campbell KH, Galerneau F, Anders AM, Lee YK, Roberts AE, Kliman HJ. (2018) Estimated placental volume and gestational age. American Journal of Perinatology, 35:748-57, 2018; doi: 10.1055/s-0037-1615285
  51. Kliman HJ, Quaratella SB, Setaro AC, Siegman EC, Subha ZT, Tal R, Milano KM, Steck TL. (2018) Pathway of Maternal Serotonin to the Human Embryo and Fetus. Endocrinology, 159:1609-1629.
  1. Feinberg RF, Blagowidow N, Pfendner EG, Wang C-L, Kliman HJ. Direct determination of fetal sex by polymerase chain reaction (PCR) amplification of amniocyte DNA: A model application for PCR in prenatal molecular diagnosis. 37th Annual Meeting of the Society for Gynecologic Investigation, 1990.
  2. Kliman HJ, Lee KS, Meaddough EL, Cole LA. hCG degradation in the human chorionic villous core. Serono SymposiumGlycoprotein Hormones, Santa Barbara, CA, 1993.
  3. Kliman HJ, Arici AM, Cunningham ME, Meaddough EL. Chorioamnionitis: a role for interleukin-8? European Placental Group 1993, Manchester, England, 1993.
  4. Kliman HJ, Meaddough EL. Placental interleukin-8 is predominantly made by villous macrophages, not trophoblasts. 42nd Annual Meeting of the Society for Gynecologic Investigation, 1995.
  5. Kliman HJ, Jones D, Morotti R. (1995) The rise and fall of villous edema as a function of time from initiation of intrauterine infection. Am J Ob Gyn 172:312 (Abstract #186).
  6. Asis A, Mari G, Rebarber A, Kern L, Kliman H. Syncytial knot (SK) formation in response to uteroplacental insufficiency (UPI) in small for gestational age (SGA) fetuses. Society of Perinatal Obstetricians, Miami, 1998.
  7. Kliman HJ, McSweet JC, La T. Syncytial knots are the source of placental CRH. Society for Maternal Fetal Medicine, Reno, NV, 2001.
  8. Kliman HJ, Segel L, Fauci L, Cortez R. Model for the formation of trophoblast inclusions in chorionic villi. Society for Maternal Fetal Medicine, Reno, NV, 2001.
  9. Kliman HJ, French L. Trophoblast inclusions are associated with karyotypic abnormalities. Society for Maternal Fetal Medicine, Reno, NV, 2001.
  10. Kliman HJ, McSweet JC, Franco A, Ying X, Zhao Y, Stetten G. Trophoblast inclusions are rare in elective terminations and normal deliveries, but common in cases with karyotypic abnormalities. American Society for Reproductive Medicine, San Antonio, Texas, 2003.
  11. Kliman HJ, Milano KM. The majority of miscarriages are caused by genetic abnormalities. 69th Conjoint Meeting of the International Federation of Fertility Societies and the American Society for Reproductive Medicine, October 12-17, 2013, Boston, MA. Fertility and Sterility, Volume 100, Issue 3, Supplement, September 2013, Page S306, ISSN 0015-0282,
  1. Ringler GE, Ulloa-Aguirre A, Kao L-C, Nulsen JC, Kallen CB, Kliman HJ, Strauss JF III. (1988) Control of chorionic gonadotropin (hCG) by cyclic AMP: Lessons from primary cultures of cytotrophoblasts. In: Placental protein hormones. Mochizuki M, Hussa R (eds), Elsevier Science Publishers, pp 183-190.
  2. Kliman HJ, Coutifaris C, Feinberg RF, Strauss JF III, Haimowitz JE. (1989) Implantation: In vitro human models utilizing human tissues. In: Blastocyst Implantation. Y. Yoshinaga (ed), Serono Symposia.
  3. Coutifaris C, Strauss JF III, Kliman HJ. (1989) Towards a cellular and molecular understanding of implantation in the human: Implications for assisted reproductive technologies. In: Institute of Medicine Monograph on Assisted Reproductive Technologies. National Academic Press, Washington D.C.
  4. Coutifaris C, Babalola GO, Feinberg RF, Kao L-C, Kliman HJ, Strauss JF III. (1990) Purified human cytotrophoblasts: Surrogates for the blastocysts in in vitro models of implantation. In: Advances in Assisted Reproductive Technologies. S. Mashiach et al (eds). Plenum Press, New York.
  5. Kliman HJ and Feinberg RF. (1992) Trophoblast Differentiation. In: The First Twelve Weeks of Gestation. Barnea ER, Hustin J, Jauniaux E (eds). Springer-Verlag, New York.
  6. Feinberg RF, Kliman HJ, Lockwood CJ. (1992) Oncofetal fibronectin: A trophoblast “glue” for human implantation? The Year Book of Obstetrics and Gynecology. Mishell et al., eds. Mosby Year Book, St. Louis, MO.
  7. Feinberg RF, Kliman HJ, Wang CL. Tropho-uteronectin (TUN): A fibronectin marker of trophoblast attachment and differentiation in vivo and in vitro. In: Local Systems in Reproduction. F. Naftolin and R. Magness (ed), Serono Symposia, 1992.
  8. Feinberg RF, Kliman HJ. (1993) Human trophoblasts and tropho-uteronectin (TUN): A model for studying early implantation events. Assisted Reproduction Rev 3:19-25.
  9. Kliman HJ. Placental Hormones. (1994) Infertility and Reproductive Medicine Clinics of North America 5:591-610.
  10. Kliman HJ. Trophoblast infiltration. (1994) Reproductive Medicine Review 3:137-157.
  11. Kliman HJ. Trophoblast to human placenta. Encyclopedia of Reproduction, Academic Press, 1999.
  12. Kliman HJ. The umbilical cord. Encyclopedia of Reproduction, Academic Press, 1999.
  13. Kliman HJ. Behind every healthy baby is a healthy placenta. In: Parenthood Lost. Berman MR (ed), Bergin & Garvey, Westport, CT, 2001, pgs 130-131.
  14. Kliman HJ. Trophoblast toxicity assay (TTA): A gestational toxicity test using human placental trophoblasts. In: Alternative toxicological methods. Salem H, Katz SA (eds), CRC Press, Boca Raton, FL, 2003, pgs 567-580.
  15. Kliman HJ, McSweet JC, Levin YA. (2005) Fetal death: etiology and pathological findings. UpToDate.
  16. Kliman HJ. Placenta. (2012) In: Encyclopedia of Autistic Spectrum Disorders. Volkmar FR (ed). Springer, New York.
Anchoring trophoblasts

Junction of normal placenta and maternal decidua showing anchoring trophoblasts (HE stain)

Mono di twin placenta

Mono chorionic diamniotic twin placenta