Angeliki Louvi, PhD

Cerebral Cavernous Malformations (CCM)

1. Louvi, A.*, Chen, L., Two, A. M., Zhang, H., Min, W., and Günel, M.* (2011). Loss of cerebral cavernous malformation 3 (Ccm3) in neuroglia leads to CCM and vascular pathology. Proc. Natl. Acad. Sci. USA. 108, 3737-3742. PMID: 21321212.
   
2. Louvi, A.*, Nishimura, S. and Gunel, M. (2014). Ccm3, a gene associated with cerebral cavernous malformations, is required for neuronal migration. Development, 141, 1404-1415. PMID: 24595293.
   
3. Nishimura, S., Mishra-Gorur, K., Park, J., Surovtseva, Y., Sebti, S.M., Levchenko, A., Louvi, A.* and Gunel, M.* (2017). Combined HMG-CoA reductase and prenylation inhibition in treatment of CCM. Proceedings of the National Academy of Sciences USA. 114(21):5503-5508. doi: 10.1073/pnas.1702942114. PMID: 28500274.
4. Peyre, M., Miyagishima, D., Bielle, F., Chapon, F., Sierant, M., Venot, Q., Lerond, J., Marijon, P., Abi-Jaoude, S., Le Van, T., Labreche, K., Houlston, R., Faisant, M., Clemenceau, S., Boch, A.-L., Nouet, A., Carpentier, A., Boetto, J., Louvi, A., Kalamarides, M. (2021) Recurrent Somatic PIK3CA mutations in Sporadic Cerebral Cavernous Malformations. New England Journal of Medicine 2021 Sep 9;385(11):996. doi: 10.1056/NEJMoa2100440. PMID: 34496175.
   
5. Louvi, A., Nishimura, S., and Gunel, M. (2022). Genetics of Cerebral Cavernous Malformations. In Youmans and Winn’s Neurological Surgery, 8^th edition, H. Richard Winn, Editor-in-Chief. Chapter 460, p.3760-3768.e6. Elsevier (Philadelphia, PA).

Structural Brain Disorders

1. Bilgüvar, K.*, Oztürk, A. K.*, Louvi, A., Kwan, K. Y., Choi, M., Tatli, B., Yalnizoglu, D., Tüysüz, B., Caglayan, A. O., Gökben, S., Kaymakçalan, H., Barak, T., Bakircioglu, M., Yasuno, K., Ho, W., Sanders, S., Zhu, Y., Yilmaz, S., Dinçer, A., Johnson, M. H., Bronen, R. A., Koçer, N., Per, H., Mane, S., Pamir, M. N., Yalçinkaya, C., Kumandas, S., Topçu, M., Ozmen, M., Sestan, N., Lifton, R. P., State, M. W., and Günel, M. (2010). Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations. Nature 467, 207-210. PMID: 20729831.
   
2. Sgourdou, P., Mishra-Gorur, K., Saotome, I., Henagariu, O., Tuysuz, B., Campos, C., Ishigame, K., Giannikou, K., Quon, J.L., Sestan, N., Caglayan, A.O., Gunel, M., and Louvi, A*. (2017) Disruptions in asymmetric centrosome inheritance and WDR62-Aurora kinase B interactions in primary microcephaly. Scientific Reports 7:43708. doi: 10.1038/srep43708. PMID: 28272472.
3. Dell’Amico, C., Angulo Salavarria, M.M., Takeo, Y., Saotome, I., Dell’Anno, M.T., Galimberti, M., Pellegrino, E., Cattaneo, E., Louvi, A.*, Onorati, M.* (2023) Microcephaly-associated protein WDR62 shuttles from the Golgi apparatus to the spindle poles in human neural progenitors. eLife Jun 5;12:e81716. doi: 10.7554/eLife.81716. PMID37272619.

Current Projects

• Cellular and Molecular Mechanisms of Structural Brain Disorders
• Biology and Pathobiology of Cerebral Cavernous Malformations
• Intracranial Aneurysms