Pietro De Camilli, MD
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About
Titles
John Klingenstein Professor of Neuroscience and Professor of Cell Biology
Investigator, Howard Hughes Medical Institute; Director, Program in Cellular Neuroscience, Neurodegeneration and RepairBiography
A native of Italy, De Camilli studied at the Liceo Manzoni in Milan, earned his M.D. degree from the University of Milano in 1972 and obtained a postgraduate degree in medical endocrinology from the University of Pavia in Italy. He was a postdoctoral fellow (1978-79) with Paul Greengard in the Department of Pharmacology at Yale, and subsequently an assistant professor in the Yale Section of Cell Biology. Following a return of a few years to Milan, he moved back to Yale in the late 1980s, where he is now John Klingenstein Professor of Neuroscience. He became an Investigator in the Howard Hughes Medical Institute in 1992. From 1997 to 2000 he served as Chair of the Department of Cell Biology and since 2005 he is Founding Director of the Yale Program in Cellular Neuroscience, Neurodegeneration and Repair (CNNR). He also served as Chair of the Department of Neuroscience from 2015 to 2021, and as Director of the Kavli Institute for Neuroscience from 2015 to 2022.
The De Camilli lab is interested in the cell biology of neuronal synapses. His studies on synaptic vesicle dynamics have contributed to the general fields of exocytosis and endocytosis. His research has provided insight into mechanisms of membrane fission and has revealed ways through which membrane-associated proteins can generate, sense and stabilize lipid bilayer curvature. His discovery and characterization of the role of phosphoinositide metabolism in the control of endocytosis have broad implications in the fields of phospholipid signaling and of membrane traffic. Building on this work, he has recently become interested in the role of membrane contact sites in the control of the homeostasis of bilayer lipids. His studies of synapses have also contributed to the elucidation of pathogenetic mechanisms of human diseases, with recent emphasis on Parkinson's disease.
Appointments
Neuroscience
ProfessorFully JointCell Biology
ProfessorFully Joint
Other Departments & Organizations
- Alzheimer's Disease Research Center (ADRC)
- Cell Biology
- De Camilli Lab
- Developmental Cell Biology and Genetics
- Diabetes Research Center
- Fellowship Training
- Interdepartmental Neuroscience Program
- Kavli Institute for Neuroscience
- Membrane Traffic
- Molecular Cell Biology, Genetics and Development
- Neuroscience
- Neuroscience Track
- NIDA Neuroproteomics Center
- Program in Cellular Neuroscience, Neurodegeneration and Repair
- Wu Tsai Institute
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
- Yale Ventures
Education & Training
- MD
- University of Milan (1972)
Research
Overview
Medical Subject Headings (MeSH)
Academic Achievements and Community Involvement
Links & Media
Media
Screen Shot 2017-10-04 at 4.25.34 PM
FIB-SEM generated 3D reconstruction of subcellular organelles present in dendritic spines of cortical neurons. (from Wu et al. PNAS 2016, PMID:28559323)dyn 1,3 DKO synapse
EM tomographic reconstruction: plasma membrane (green lines) and clathrin coated endocytic intermediates in an axon terminal from a neuron that lacks both dynamin 1 and dynamin 3 (dynamin 1 and 3 double KO mouse).
News
- May 03, 2024
Hao, Chen, and Bhaskar Honored With 2024 Kavli Postdoctoral Fellowship
- August 15, 2023
Yale Researchers Reveal Key to Neuronal Transport System
- April 27, 2023
De Camilli awarded the van Deenan Medal for Biomembrane Research
- July 14, 2022Source: YaleNews
Scientists Zero in on Genetic Causes of Parkinson’s