Marcelo de Oliveira Dietrich, MD, PhD
he/him/his
Associate Professor in Comparative MedicineDownloadHi-Res Photo
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Additional Titles
Associate Professor, Neuroscience
Founder and Director, NA
Contact Info
Appointments
Comparative Medicine
Primary
Neuroscience
Secondary
Additional Titles
Associate Professor, Neuroscience
Founder and Director, NA
Contact Info
Appointments
Comparative Medicine
Primary
Neuroscience
Secondary
Additional Titles
Associate Professor, Neuroscience
Founder and Director, NA
Contact Info
About
Titles
Associate Professor in Comparative Medicine
Associate Professor, Neuroscience; Founder and Director, NA
Appointments
Comparative Medicine
Associate Professor TenurePrimaryNeuroscience
Associate Professor on TermSecondary
Other Departments & Organizations
Education & Training
- Associate Research Scientist
- Yale School of Medicine (2014)
- Postdoctoral fellow
- Yale School of Medicine (2012)
- PhD
- Universidade Federal do Rio Grande do Sul, Biochemistry (2012)
- Physician (general practice)
- NA (2008)
- MD
- Universidade Federal do Rio Grande do Sul (2007)
- Research assistant
- Yale School of Medicine
- Research assistant
- Cajal Institute (2005)
Board Certifications
General Medicine
- Certification Organization
- Medical Council of the State of Rio Grande do Sul, Brazil
- Original Certification Date
- 2007
Research
Overview
Medical Research Interests
Animals; Behavior and Behavior Mechanisms; Hypothalamus; Mental Disorders; Mental Health; Nervous System; Neurobiology; Neurosciences; Obesity
Public Health Interests
Genetics, Genomics, Epigenetics; Evolution; Child/Adolescent Health; Aging; Behavioral Health; Bioinformatics; Nutrition; Obesity; Perinatal/Prenatal Health; Mental Health; Substance Use, Addiction; Metabolism
ORCID
0000-0001-9781-2221- View Lab Website
Dietrich Lab
Research at a Glance
Yale Co-Authors
Frequent collaborators of Marcelo de Oliveira Dietrich's published research.
Publications Timeline
A big-picture view of Marcelo de Oliveira Dietrich's research output by year.
Research Interests
Research topics Marcelo de Oliveira Dietrich is interested in exploring.
Tamas Horvath, DVM, PhD
Marcelo Rigon Zimmer, PhD, BS
Onur Iyilikci
Gustavo Madeira Santana
Jeremy Bober
Zhongwu Liu, MD
19Publications
1,482Citations
Publications
Featured Publications
Neurons for infant social behaviors in the mouse zona incerta
Li Y, Liu Z, Santana G, Capaz A, Doumazane E, Gao X, Renier N, Dietrich M. Neurons for infant social behaviors in the mouse zona incerta. Science 2024, 385: 409-416. PMID: 39052814, DOI: 10.1126/science.adk7411.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsInfant social behaviorSocial behaviorZona incertaSomatostatin-expressing neuronsNeural basisInfant behaviorBehavioral distressEmotional developmentMaternal presenceNeural activity manipulationFacilitation of learningBrain centersSocial interactionPopulations of neuronsInfant mouse brainPreweaning miceMouse brainNeuronsInfantsMiceActive manipulationBehaviorMothersDistressIncertaImmune sensing of food allergens promotes avoidance behaviour
Florsheim E, Bachtel N, Cullen J, Lima B, Godazgar M, Carvalho F, Chatain C, Zimmer M, Zhang C, Gautier G, Launay P, Wang A, Dietrich M, Medzhitov R. Immune sensing of food allergens promotes avoidance behaviour. Nature 2023, 620: 643-650. PMID: 37437602, PMCID: PMC10432274, DOI: 10.1038/s41586-023-06362-4.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsMast cellsImmune systemBALB/c miceAllergen-specific IgEDifferentiation factor 15Behavioral modificationAllergen avoidanceAllergic sensitizationAllergic inflammationFood allergyTractus solitariusC miceCysteinyl leukotrienesParabrachial nucleusAllergen ingestionE antibodiesCentral amygdalaFactor 15Mouse modelFood allergensBrain areasImmune sensingAvoidance behaviorAversive stimuliGenetic backgroundDevelopment of “Hunger Neurons” and the Unanticipated Relationship Between Energy Metabolism and Mother-Infant Interactions
Iyilikci O, Zimmer MR, Dietrich MO. Development of “Hunger Neurons” and the Unanticipated Relationship Between Energy Metabolism and Mother-Infant Interactions. Biological Psychiatry 2022, 91: 907-914. PMID: 35397878, PMCID: PMC10184517, DOI: 10.1016/j.biopsych.2022.02.962.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsFunctional Ontogeny of Hypothalamic Agrp Neurons in Neonatal Mouse Behaviors
Zimmer MR, Fonseca AHO, Iyilikci O, Pra RD, Dietrich MO. Functional Ontogeny of Hypothalamic Agrp Neurons in Neonatal Mouse Behaviors. Cell 2019, 178: 44-59.e7. PMID: 31104844, PMCID: PMC6688755, DOI: 10.1016/j.cell.2019.04.026.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsHypothalamic AgRP neuronsAgRP neuronsAdult micePostnatal day 10 miceVivo fiber photometryFunctional ontogenyIsolation-induced ultrasonic vocalizationsNon-nutritive sucklingUltrasonic vocalizationsMilk ingestionFiber photometryMilk deprivationFood ingestionNeuronsMiceMouse behaviorIngestionNeonatesGABALittermatesOveractivation
2024
What makes each of us unique? The nine-banded armadillo as a model to study individuality
Leao D, Duque A, Dietrich M. What makes each of us unique? The nine-banded armadillo as a model to study individuality. Frontiers In Mammal Science 2024, 3: 1450655. DOI: 10.3389/fmamm.2024.1450655.Peer-Reviewed Original ResearchConceptsScience of individualityInter-individual differencesNine-banded armadilloBrain-related traitsSources of varianceBiology of individualsBrain structuresGenetic clonesReproductive biologyArmadillosHuman brainBrainMammalian brainStochastic factorsBiological mechanismsScienceIndividualsBiologyStudy individualsComplex interplayEmotionsClonesThoughtsNeuroscienceArguments
2022
AgRP neurons control structure and function of the medial prefrontal cortex
Stutz B, Waterson MJ, Šestan-Peša M, Dietrich MO, Škarica M, Sestan N, Racz B, Magyar A, Sotonyi P, Liu ZW, Gao XB, Matyas F, Stoiljkovic M, Horvath TL. AgRP neurons control structure and function of the medial prefrontal cortex. Molecular Psychiatry 2022, 27: 3951-3960. PMID: 35906488, PMCID: PMC9891653, DOI: 10.1038/s41380-022-01691-8.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsMedial prefrontal cortexAgRP neuronsNon-selective dopamine receptor antagonistBrain functionPrefrontal cortexHypothalamic AgRP neuronsMedial thalamic neuronsAdministration of clozapineDopamine receptor antagonistVentral tegmental areaOscillatory network activityHigher-order brain functionsHypothalamic agoutiThalamic neuronsChemogenetic inhibitionDopaminergic neuronsReceptor antagonistTegmental areaNeuronal pathwaysSensorimotor gatingAdult miceModulatory impactAmbulatory behaviorConstitutive impairmentNeuronsPreparatory neurons for building a nest
Iyilikci O, Dietrich MO. Preparatory neurons for building a nest. Neuron 2022, 110: 1283-1285. PMID: 35447098, DOI: 10.1016/j.neuron.2022.03.023.Peer-Reviewed Original ResearchMeSH Keywords and Concepts
2021
Deficiency of the paternally inherited gene Magel2 alters the development of separation‐induced vocalization and maternal behavior in mice
Ortiz G, Santana GM, Dietrich MO. Deficiency of the paternally inherited gene Magel2 alters the development of separation‐induced vocalization and maternal behavior in mice. Genes Brain & Behavior 2021, 21: e12776. PMID: 34812568, PMCID: PMC9744533, DOI: 10.1111/gbb.12776.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsOrigin-specific mannerGenomic imprintingMouse developmentPaternal genesMammalian offspringDeficient offspringLoss of Magel2Specific mannerGene Magel2GenesOffspring resultsMAGEL2Combined expressionOffspringAltered behaviorSeparation-induced vocalizationsVocal behaviorExpressionMammalsPostnatal developmentGrowthImprintingPup growthAnalysis of ultrasonic vocalizations from mice using computer vision and machine learning
Fonseca A, Santana GM, Ortiz G, Bampi S, Dietrich MO. Analysis of ultrasonic vocalizations from mice using computer vision and machine learning. ELife 2021, 10: e59161. PMID: 33787490, PMCID: PMC8057810, DOI: 10.7554/elife.59161.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsMachine learning methodsUser-defined parametersDimensionality reduction toolComputer visionComputational visionMachine learningUser inputAudio filesLearning methodsDifferential geometry approachData setsGeometry approachProbability distributionRelevant informationVisionReduction toolRobust methodSoftwareFilesLearningClassificationInformationSetNeedTool
2020
AgRP neurons control compulsive exercise and survival in an activity-based anorexia model
Miletta MC, Iyilikci O, Shanabrough M, Šestan-Peša M, Cammisa A, Zeiss CJ, Dietrich MO, Horvath TL. AgRP neurons control compulsive exercise and survival in an activity-based anorexia model. Nature Metabolism 2020, 2: 1204-1211. PMID: 33106687, DOI: 10.1038/s42255-020-00300-8.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsAgRP neuronsActivity-based anorexia modelAgRP neuronal activityVivo fiber photometryFood-restricted miceFood-restricted animalsCompulsive exerciseAnorexia modelHypothalamic agoutiNeuropeptide YExercise volumeFood intakeMouse modelNeuronal activityFiber photometryDaily activationNeuronal circuitsPsychiatric conditionsAnorexia nervosaChemogenetic toolsNeuronsLong-term behavioral impactElevated fat contentVoluntary cessationFat content
News & Links
Media
News
- October 10, 2023
Immune Sensing of Allergens Promotes Avoidance Behavior
- November 09, 2015
2014 YCCI Scholars
- September 24, 2015
Of brains and bones: How hunger neurons control bone mass
- March 09, 2015
Multitasking hunger neurons also control compulsive behavior
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New Haven, CT 06510
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