2020
Genetic underpinnings of cerebral edema in acute brain injury: an opportunity for pathway discovery
Kirsch E, Szejko N, Falcone GJ. Genetic underpinnings of cerebral edema in acute brain injury: an opportunity for pathway discovery. Neuroscience Letters 2020, 730: 135046. PMID: 32464484, PMCID: PMC7372633, DOI: 10.1016/j.neulet.2020.135046.Peer-Reviewed Original ResearchConceptsAcute brain injuryCerebral edemaBrain injuryEdema formationIntracerebral hemorrhageWorse outcomesBlood-brain barrier disruptionSecondary brain injuryBrain edema formationTraumatic brain injuryApolipoprotein E geneSecondary injuryBarrier disruptionVasogenic edemaCytotoxic edemaInflammatory processUseful intermediate phenotypeEdemaTherapeutic targetAquaporin-4Haptoglobin geneInjuryHp 2Novel susceptibility genesNon-white populationsGenetic Variation and Response to Neurocritical Illness: a Powerful Approach to Identify Novel Pathophysiological Mechanisms and Therapeutic Targets
Acosta JN, Brown SC, Falcone GJ. Genetic Variation and Response to Neurocritical Illness: a Powerful Approach to Identify Novel Pathophysiological Mechanisms and Therapeutic Targets. Neurotherapeutics 2020, 17: 581-592. PMID: 31975153, PMCID: PMC7283396, DOI: 10.1007/s13311-020-00837-2.Peer-Reviewed Original ResearchConceptsIll neurological patientsNovel pathophysiological mechanismsFinal FDA approvalNeurocritical illnessPathophysiological mechanismsTherapeutic optionsNeurocritical care researchTherapeutic targetNeurological patientsNew treatmentsFDA approvalNovel interventionsCare researchNew preventiveRehabilitation strategiesBiological pathwaysPatientsIllness
2017
Genetics of Spontaneous Intracerebral Hemorrhage
Falcone GJ, Woo D. Genetics of Spontaneous Intracerebral Hemorrhage. Stroke 2017, 48: 3420-3424. PMID: 29114093, PMCID: PMC5777521, DOI: 10.1161/strokeaha.117.017072.Peer-Reviewed Original Research