2016
CT Angiography Spot Sign, Hematoma Expansion, and Outcome in Primary Pontine Intracerebral Hemorrhage
Morotti A, Jessel MJ, Brouwers HB, Falcone GJ, Schwab K, Ayres AM, Vashkevich A, Anderson CD, Viswanathan A, Greenberg SM, Gurol ME, Romero JM, Rosand J, Goldstein JN. CT Angiography Spot Sign, Hematoma Expansion, and Outcome in Primary Pontine Intracerebral Hemorrhage. Neurocritical Care 2016, 25: 79-85. PMID: 26759226, PMCID: PMC4940347, DOI: 10.1007/s12028-016-0241-2.Peer-Reviewed Original ResearchConceptsPrimary pontine hemorrhagePositive predictive valueSupratentorial intracerebral hemorrhageIntracerebral hemorrhageHematoma expansionHospital mortalitySpot signNegative predictive valuePredictive valueNon-contrast CT scanCT angiography spot signAbsolute hematoma growthBrainstem ICHTomography angiography spot signConsecutive ICH patientsComputer-assisted volumetric analysisSpot sign presenceNegative likelihood ratioCTA spot signCollected cohortICH patientsPontine hemorrhagePPH casesHematoma growthHematoma volume
2014
Risk Factors for Computed Tomography Angiography Spot Sign in Deep and Lobar Intracerebral Hemorrhage Are Shared
Radmanesh F, Falcone GJ, Anderson CD, Battey TW, Ayres AM, Vashkevich A, McNamara KA, Schwab K, Romero JM, Viswanathan A, Greenberg SM, Goldstein JN, Rosand J, Brouwers HB. Risk Factors for Computed Tomography Angiography Spot Sign in Deep and Lobar Intracerebral Hemorrhage Are Shared. Stroke 2014, 45: 1833-1835. PMID: 24876264, PMCID: PMC4116606, DOI: 10.1161/strokeaha.114.005276.Peer-Reviewed Original ResearchConceptsLobar intracerebral hemorrhageComputed tomography angiographyBaseline ICH volumeIntracerebral hemorrhagePrimary intracerebral hemorrhageSpot signTomography angiographyICH locationICH volumeMultivariable regressionChronic cerebral small vessel diseaseCerebral small vessel diseaseDeep intracerebral hemorrhageSmall vessel diseaseTomography angiography spot signLobar ICH patientsComputed tomography angiography spot signAvailable computed tomography angiographySpot sign presenceSymptom onsetICH patientsPoor outcomeVessel diseaseAcute manifestationsHematoma expansionPredicting Hematoma Expansion After Primary Intracerebral Hemorrhage
Brouwers HB, Chang Y, Falcone GJ, Cai X, Ayres AM, Battey TW, Vashkevich A, McNamara KA, Valant V, Schwab K, Orzell SC, Bresette LM, Feske SK, Rost NS, Romero JM, Viswanathan A, Chou S, Greenberg SM, Rosand J, Goldstein JN. Predicting Hematoma Expansion After Primary Intracerebral Hemorrhage. JAMA Neurology 2014, 71: 158-164. PMID: 24366060, PMCID: PMC4131760, DOI: 10.1001/jamaneurol.2013.5433.Peer-Reviewed Original ResearchConceptsPrimary intracerebral hemorrhageIndependent validation cohortIntracerebral hemorrhageHematoma expansionValidation cohortHigh riskPrediction scoreUrban academic medical centerBaseline ICH volumeWarfarin sodium useProspective cohort studyAcute intracerebral hemorrhageMultivariable logistic regressionTomography angiography spot signComputed tomography angiography spot signAcademic medical centerPredictors of expansionCohort studyMultivariable analysisDevelopment cohortICH volumeC-statisticClinical trialsIndividualized treatmentMAIN OUTCOME