2021
Mendelian Randomization in Stroke: A Powerful Approach to Causal Inference and Drug Target Validation
Acosta JN, Szejko N, Falcone GJ. Mendelian Randomization in Stroke: A Powerful Approach to Causal Inference and Drug Target Validation. Frontiers In Genetics 2021, 12: 683082. PMID: 34456968, PMCID: PMC8387928, DOI: 10.3389/fgene.2021.683082.Peer-Reviewed Original ResearchMendelian randomizationCardiovascular risk factorsRisk of strokeAvailable treatment optionsInflammation-related mechanismsIschemic strokeHemorrhagic strokeTreatment optionsRisk factorsLeading causeCurrent evidenceTherapeutic targetStrokeMR studiesNovel biological pathwaysDrug repurposingDrug developmentDrug target validationRandomizationTarget validationExposureBiological pathwaysCausal relationshipDiseasePowassan Meningoencephalitis: A Case Report Highlighting Diagnosis and Management
Pach JJ, Zubair AS, Traner C, Falcone GJ, Dewey JJ, Traner C. Powassan Meningoencephalitis: A Case Report Highlighting Diagnosis and Management. Cureus 2021, 13: e16592. PMID: 34430178, PMCID: PMC8378285, DOI: 10.7759/cureus.16592.Peer-Reviewed Original ResearchChronic Kidney Disease is Associated with Higher Risk and Worse Outcome after Spontaneous Intracerebral Hemorrhage (2729)
Leasure A, Vanent K, Acosta J, Woo D, Murthy S, Kamel H, Cohen J, Townsend R, Petersen N, Sansing L, Gill T, Sheth K, Falcone G. Chronic Kidney Disease is Associated with Higher Risk and Worse Outcome after Spontaneous Intracerebral Hemorrhage (2729). Neurology 2021, 96 DOI: 10.1212/wnl.96.15_supplement.2729.Peer-Reviewed Original Research
2014
Accuracy of imputation to infer unobserved APOE epsilon alleles in genome-wide genotyping data
Radmanesh F, Devan WJ, Anderson CD, Rosand J, Falcone GJ. Accuracy of imputation to infer unobserved APOE epsilon alleles in genome-wide genotyping data. European Journal Of Human Genetics 2014, 22: 1239-1242. PMID: 24448547, PMCID: PMC4169533, DOI: 10.1038/ejhg.2013.308.Peer-Reviewed Original ResearchMeSH KeywordsAllelesAlzheimer DiseaseApolipoproteins ECase-Control StudiesCerebral HemorrhageGene FrequencyGenome, HumanGenome-Wide Association StudyGenotypeGenotyping TechniquesHapMap ProjectHumansLogistic ModelsLongitudinal StudiesPolymorphism, Single NucleotidePrincipal Component AnalysisProspective StudiesQuality ControlWhite PeopleConceptsIntracerebral hemorrhageAlzheimer's diseaseSingle nucleotide polymorphismsEpsilon allelesAPOE epsilon allelesCerebral amyloid angiopathyLate-onset Alzheimer's diseaseCatabolism of chylomicronsLow-density lipoproteinGenetic risk factorsAmyloid angiopathyCommon single nucleotide polymorphismsRisk factorsApolipoprotein EDensity lipoproteinControl groupMain apoproteinApoEDiseaseGenome-wide genotyping dataEuropean ancestryImproved balanceHapMap reference panelsGenome-wide genotyping arraysAlleles