Anjali Jacob Panicker, PhD, MS
Postdoctoral AssociateAbout
Research
Publications
2024
Tricky Ts play possum to propagate autoimmune disease.
Panicker A, O'Connor K. Tricky Ts play possum to propagate autoimmune disease. Science Immunology 2024, 9: eadt4136. PMID: 39365872, DOI: 10.1126/sciimmunol.adt4136.Peer-Reviewed Original ResearchOutcome-based Risk Assessment of Non-HLA Antibodies in Heart Transplantation: A Systematic Review
Panicker A, Prokop L, Hacke K, Jaramillo A, Griffiths L. Outcome-based Risk Assessment of Non-HLA Antibodies in Heart Transplantation: A Systematic Review. The Journal Of Heart And Lung Transplantation 2024, 43: 1450-1467. PMID: 38796046, DOI: 10.1016/j.healun.2024.05.012.Peer-Reviewed Original ResearchConceptsNon-HLA antibodiesEndomyocardial biopsyHeart transplantationRejection pathologyDonor-specific anti-human leukocyte antigen antibodiesAnti-human leukocyte antigen antibodiesHistocompatibility complex class I chain-related gene ANon-human leukocyte antigenSystematic reviewNon-HLA antigensStrength of evidenceAntibody-mediated rejectionInvasive endomyocardial biopsyPositive endomyocardial biopsyClinical risk stratificationHLA-DSAHT recipientsRejection monitoringLeukocyte antigenRisk stratificationRejection eventsRisk factorsInclusion criteriaAntigen antibodiesAntibodies
2023
A single-center assessment of mental health and well-being in a biomedical sciences graduate program
Jachim S, Bowles B, Panicker A, Yousaf I, Brown A, Zoroufy A, Boehmer K, Stonnington C, Vadeboncoeur T, Lujan J, Ehlers S, Schulze A. A single-center assessment of mental health and well-being in a biomedical sciences graduate program. Nature Biotechnology 2023, 41: 728-733. PMID: 37193845, DOI: 10.1038/s41587-023-01778-9.Peer-Reviewed Original ResearchComplete tolerogenic response adjuvant stimulates Treg response to immunization
JANJAM S, Geng Y, yan Z, Shin S, Joshi K, Panicker A, shankar A, Elangovan R, Koehler J, Gnanasekar V, williams A, Feng A, ellis C, Vattikota A, Chen A, Zheng G. Complete tolerogenic response adjuvant stimulates Treg response to immunization. The Journal Of Immunology 2023, 210: 158.08-158.08. DOI: 10.4049/jimmunol.210.supp.158.08.Peer-Reviewed Original ResearchTolerogenic adjuvantAntigen-specific immunosuppressionMonophosphoryl lipid AMouse model of atherosclerosisResponse to immunizationTreg responsesTreg cellsModel of atherosclerosisAutoimmune/inflammatory diseasesVaccination regimenMurine modelNovel adjuvantsAntigen immunizationApoE-/- mouse modelVaccine adjuvantsB antigenAdjuvantImmunogenic substancesTregsVaccineImmunological illnessesImmunityLipid AOptimization of a high-throughput shotgun immunoproteomics pipeline for antigen identification
Shortreed N, Panicker A, Mangalaparthi K, Zhong J, Pandey A, Griffiths L. Optimization of a high-throughput shotgun immunoproteomics pipeline for antigen identification. Journal Of Proteomics 2023, 281: 104906. PMID: 37059220, PMCID: PMC10399726, DOI: 10.1016/j.jprot.2023.104906.Peer-Reviewed Original ResearchConceptsAdaptive immune responsesImmune responseAntigen identificationPreparation of protein extractsProtein extractsIdentification of proteinsImmunoproteomic approachAffinity chromatography columnIntra-experimental variabilityTrifluoroacetic acidPre-clinicalUnique antigensDisruption methodsTMT labelingLC-MS/MSHypothesis-driven approachIncreased total numberAntigenLC-MS/MS analysisAntigenic proteinsMass spectrometry timeProteinHigh-throughputLongitudinal mannerImmunoprecipitationComplete Tolerogenic Adjuvant Stimulates Regulatory T Cell Response to Immunization.
Zheng G, Geng Y, Yan Z, Shin S, Joshi K, Panicker A, Shankar A, Elangovan R, Koehler J, Gnanasekar V, Gilles J, Munirathinam G, Chen A. Complete Tolerogenic Adjuvant Stimulates Regulatory T Cell Response to Immunization. The Journal Of Immunology 2023, 210: 609-617. PMID: 36602931, PMCID: PMC9998350, DOI: 10.4049/jimmunol.2200463.Peer-Reviewed Original Research
2021
Shotgun Immunoproteomics for Identification of Nonhuman Leukocyte Antigens Associated With Cellular Dysfunction in Heart Transplant Rejection
Gates K, Panicker A, Biendarra-Tiegs S, Vetr N, Higuita M, Nelson T, Pereira N, Griffiths L. Shotgun Immunoproteomics for Identification of Nonhuman Leukocyte Antigens Associated With Cellular Dysfunction in Heart Transplant Rejection. Transplantation 2021, 106: 1376-1389. PMID: 34923540, DOI: 10.1097/tp.0000000000004012.Peer-Reviewed Original ResearchConceptsAntibody-mediated rejectionHeart transplant recipientsAntigen-specific responsesNon-HLAPrevalence antigensAcute rejectionTransplant recipientsAbsence of donor-specific anti-HLA antibodiesDonor-specific anti-HLA antibodiesNon-HLA antibody responsesAntibody-mediated rejection patientsNon-AMR patientsAnti-HLA antibodiesHeart transplant rejectionPatient immunoglobulin GHigh-prevalence antigenEndothelial cell functionEndomyocardial biopsyAllograft rejectionGraft rejectionHeart biopsiesTransplant rejectionAntibody responseImmunofluorescence stainingPatients
2020
Role of non-HLA antigens in cardiac transplant rejection
Panicker A, Gates K, Biendarra-Tiegs S, Vetr N, Higuita M, Nelson T, Pereira N, Griffiths L. Role of non-HLA antigens in cardiac transplant rejection. The Journal Of Immunology 2020, 204: 161.7-161.7. DOI: 10.4049/jimmunol.204.supp.161.7.Peer-Reviewed Original ResearchNon-HLA antigensNon-HLA antibodiesHeart transplant patientsHuman leukocyte antigenImmune responseTransplant patientsTransplant rejectionDonor-specific anti-HLA antibodiesTerm survivalNon-HLA antibody responsesSpecific anti-HLA antibodiesAnti-HLA antibodiesCardiac allograft vasculopathyHeart transplant recipientsCardiac transplant rejectionHeart transplant rejectionCell mediated rejectionAdaptive immune responsesLong-term survivalShort-term survivalAllograft vasculopathyRejection incidenceAcute rejectionTransplant recipientsAntigen expressionImmunoproteomic identification of in vivo response toward residual antigenic proteins in xenogeneic heart valve biomaterials
Shortreed N, Panicker A, Dalgliesh A, Gates K, Griffiths L. Immunoproteomic identification of in vivo response toward residual antigenic proteins in xenogeneic heart valve biomaterials. The Journal Of Immunology 2020, 204: 161.9-161.9. DOI: 10.4049/jimmunol.204.supp.161.9.Peer-Reviewed Original ResearchCurrent heart valve prosthesesContext of tissue engineeringValve replacementTissue engineeringManagement of valvular heart diseaseECM scaffoldsValvular heart diseaseHeart valve prosthesesBovine pericardiumHumoral IgG responseNew Zealand white rabbitsZealand white rabbitsAntigen burdenNative BPIgG responsesTherapeutic approachesBiomaterialsExtracellular matrixValve prosthesisHeart diseaseRabbit modelRegenerative capacityAntigenTreatment groupsScaffolds
2019
Raising Endogenous Anti-HMGB1 IgM Antibody for Athero-Protection in the Apoe−/− Mouse Model of Atherosclerosis
Hariharasubramanian A, Elangovan R, Shankar A, Giacobazzi M, Broski A, Panicker A, Shin S, Chen A, Zheng G. Raising Endogenous Anti-HMGB1 IgM Antibody for Athero-Protection in the Apoe−/− Mouse Model of Atherosclerosis. The Journal Of Immunology 2019, 202: 196.30-196.30. DOI: 10.4049/jimmunol.202.supp.196.30.Peer-Reviewed Original ResearchMouse model of atherosclerosisWestern type dietModel of atherosclerosisB cellsIgM antibodiesReduce atherosclerosisIgM-producing B cellsB-1 cellsAnti-atherogenic efficacyNon-treated groupAortic archTreated miceAortic rootC57BL/6 miceApoE-/- mouse modelMouse modelIgM responseWeeks of ageHealthy humansAthero-protectiveMiceAtherosclerosisImmunitySpontaneous productionType diet