Guido Falcone, MD, ScD, MPH

Assistant Professor of Neurology; Staff Neurointensivist, Yale-New Haven Hospital; Broad Institute of MIT and Harvard

Departments & Organizations

Neurology: Neuro Intensive Care & Neurological Emergencies

Center for Neuroepidemiology and Clinical Neurological Research

Yale Medicine


I am a Neurologist with subspecialty training in Neurocritical Care and Stroke, and an Epidemiologist with expertise in Population Genetics and Big Data. While on clinical duties, I treat critically ill patients that have sustained a significant neurological injury due to ischemic stroke, subarachnoid hemorrhage, intraparenchymal hemorrhage, traumatic brain injury, seizures, recent neurosurgery, decompensated neuromuscular diseases, and several others.

My research lies at the interphase of clinical neurology, neuroimaging, population and medical genetics, and Big Data. I am interested in understanding how common and rare genetic variation influences the occurrence, severity, functional outcome and recurrence of stroke, both hemorrhagic and ischemic. Genetic variants influencing these phenotypes can be used for numerous applications, including: (1) identification of novel biological mechanisms involved in causing stroke and determining its severity and outcome, (2) answering non-genetic epidemiological questions using gene mutations as instruments (in the statistical sense of the word), and (3) risk stratification of patients according to their genetic profile. Through the International Stroke Genetics Consortium, I work in close collaboration with numerous investigators interested in stroke genomics from around the world.

Education & Training

ScD Harvard School of Public Health, Department of Epidemiology (2014)
MPH Harvard School of Public Health, Quantitative Methods (2010)
MD University of Buenos Aires School of Medicine (2001)
Board Certification United Council for Neurologic Subspecialties, Neurocritical Care (2017)
Neurocritical Care Fellowship Harvard Medical School / Massachusetts General Hospital / Brigham and Women's Hospital
SPOTRIAS Fellowship Massachusetts General Hospital
Neurology Residency F.L.E.N.I.

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Contact Info

Guido Falcone, MD, ScD, MPH
Mailing Address
Neurology20 York street
LLCI 10th floor

New Haven, CT 06520