Perforin Is Detrimental to Controllinγ C. muridarum Replication In Vitro, but Not In Vivo
Johnson RM, Kerr MS, Slaven JE. Perforin Is Detrimental to Controllinγ C. muridarum Replication In Vitro, but Not In Vivo. PLOS ONE 2013, 8: e63340. PMID: 23691028, PMCID: PMC3653963, DOI: 10.1371/journal.pone.0063340.Peer-Reviewed Original ResearchConceptsGenital tract infectionPerforin knockout miceChlamydia replicationTract infectionsEpithelial cellsKnockout miceC. muridarum genital tract infectionChlamydia muridarum Genital Tract InfectionClearance mechanismsVivo clearance mechanismsCD4 T cellsT cell mechanismsT cell-epithelial cell interactionsT cell degranulationNitric oxide productionBacterial clearanceEpithelial productionCell degranulationT cellsSingle-gene knockout miceWeek 7Oxide productionPerforinNitric oxideInfection