2022
Combining Cellular Immunology With RNAseq to Identify Novel Chlamydia T-Cell Subset Signatures
Johnson RM, Asashima H, Mohanty S, Shaw AC. Combining Cellular Immunology With RNAseq to Identify Novel Chlamydia T-Cell Subset Signatures. The Journal Of Infectious Diseases 2022, 225: 2033-2042. PMID: 35172331, PMCID: PMC9159333, DOI: 10.1093/infdis/jiac051.Peer-Reviewed Original ResearchConceptsProtective T cell clonesAntibacterial effector mechanismsT cells residentB cell helpT cell clonesCytokine polarizationImmune miceIL-10Protective immunityVaccine trialsIL-13Surrogate biomarkerEffector mechanismsGenital tractT cellsVaccine candidatesChlamydia trachomatisCells residentHelper functionCellular immunologyMouse studiesHuman investigationsReproductive tractGranzyme A.Investigational data
2020
A Class II-Restricted CD8γ13 T-Cell Clone Protects During Chlamydia muridarum Genital Tract Infection
Johnson RM, Olivares-Strank N, Peng G. A Class II-Restricted CD8γ13 T-Cell Clone Protects During Chlamydia muridarum Genital Tract Infection. The Journal Of Infectious Diseases 2020, 221: 1895-1906. PMID: 31899500, PMCID: PMC7213565, DOI: 10.1093/infdis/jiz685.Peer-Reviewed Original ResearchConceptsGenital tract infectionCD8 T cellsT cell clonesChlamydia muridarum Genital Tract InfectionMHC class IIT cellsTract infectionsClass IIClass IAntigen-specific CD8 T cellsChlamydia genital tract infectionCD8 T cell clonesCD4 T cell numbersMajor histocompatibility complex class IAdoptive transfer studiesT cell numbersT cell responsesHistocompatibility complex class IComplex class IBacterial clearanceIL-13IL-5ImmunopathologyIntracellular pathogensInfection