2019
The Injectisome, a Complex Nanomachine for Protein Injection into Mammalian Cells
Lara-Tejero M, Galán JE. The Injectisome, a Complex Nanomachine for Protein Injection into Mammalian Cells. EcoSal Plus 2019, 8: 10.1128/ecosalplus.esp-0039-2018. PMID: 30942149, PMCID: PMC6450406, DOI: 10.1128/ecosalplus.esp-0039-2018.Peer-Reviewed Original ResearchMeSH KeywordsBacterial ProteinsEukaryotic CellsGram-Negative BacteriaHost-Pathogen InteractionsProtein TransportType III Secretion SystemsVirulence FactorsConceptsEffector proteinsGram-negative bacteriaSecretion systemBacterial envelopeType III protein secretion systemProtein secretion systemHost cellular functionsEukaryotic plasma membraneEukaryotic cell membranesHost cell cytosolMultiprotein nanomachineEukaryotic hostsComplex nanomachinesImportant bacterial pathogensCellular functionsMammalian cellsNeedle complexOuter membranePlasma membraneCell cytosolInjectisomeCell membraneProteinBacterial pathogensCentral role
2002
Cytolethal distending toxin: limited damage as a strategy to modulate cellular functions
Lara-Tejero M, Galán JE. Cytolethal distending toxin: limited damage as a strategy to modulate cellular functions. Trends In Microbiology 2002, 10: 147-152. PMID: 11864825, DOI: 10.1016/s0966-842x(02)02316-8.Peer-Reviewed Original ResearchConceptsCytolethal distending toxinHost cell functionsDistending toxinDNA damage responseDelivery of CdtBGram-negative pathogenic bacteriaCell cycle progressionPathogenic bacteriaCell functionLimited DNA damageEukaryotic cellsCellular functionsCycle progressionAB toxinsCell cycleNuclease activityCDT holotoxinDNA damageObserved arrestActive subunitSubunitsBacterial pathogensCdtBPathogensMechanism of action