2024
Cilia structure and intraflagellar transport differentially regulate sensory response dynamics within and between C. elegans chemosensory neurons
Philbrook A, O’Donnell M, Grunenkovaite L, Sengupta P. Cilia structure and intraflagellar transport differentially regulate sensory response dynamics within and between C. elegans chemosensory neurons. PLOS Biology 2024, 22: e3002892. PMID: 39591402, PMCID: PMC11593760, DOI: 10.1371/journal.pbio.3002892.Peer-Reviewed Original ResearchConceptsIntraflagellar transportOrganization of signaling moleculesASH nociceptive neuronsAWA olfactory neuronsCiliary traffickingNociceptive neuronsCilia baseOlfactory neuronsCaenorhabditis elegansOdor responsesSignaling proteinsCilia organizationSensory neuronsCilium structurePrimary ciliaCilia structureSignaling moleculesAcute inhibitionSegregation of receptorsRegulation of responsesChemosensory neuronsNeuron typesCilium lengthNeuronal responsesEctopic branching
2022
Developmental history modulates adult olfactory behavioral preferences via regulation of chemoreceptor expression in Caenorhabditiselegans
Kyani-Rogers T, Philbrook A, McLachlan I, Flavell S, O’Donnell M, Sengupta P. Developmental history modulates adult olfactory behavioral preferences via regulation of chemoreceptor expression in Caenorhabditiselegans. Genetics 2022, 222: iyac143. PMID: 36094348, PMCID: PMC9630977, DOI: 10.1093/genetics/iyac143.Peer-Reviewed Original ResearchConceptsChemoreceptor genesDAF-16 FOXO transcription factorODR-10FOXO transcription factorsDistinct gene expression profilesGene expression profilesDauer arrestChemoreceptor expressionDauer stageAWA neuronsDauer larvaeC. elegansTranscription factorsTranscriptional profilingBehavioral plasticityPosttranscriptional mechanismsTranscriptional upregulationAdult physiologyExpression patternsExpression profilesSorted populationsBehavioral preferencesVolatile odorantsCaenorhabditiselegansReceptor regulationContext-dependent reversal of odorant preference is driven by inversion of the response in a single sensory neuron type
Khan M, Hartmann A, O’Donnell M, Piccione M, Pandey A, Chao P, Dwyer N, Bargmann C, Sengupta P. Context-dependent reversal of odorant preference is driven by inversion of the response in a single sensory neuron type. PLOS Biology 2022, 20: e3001677. PMID: 35696430, PMCID: PMC9232122, DOI: 10.1371/journal.pbio.3001677.Peer-Reviewed Original Research
2021
Combinatorial Assembly of Modular Glucosides via Carboxylesterases Regulates C. elegans Starvation Survival
Wrobel C, Yu J, Rodrigues P, Ludewig A, Curtis B, Cohen S, Fox B, O’Donnell M, Sternberg P, Schroeder F. Combinatorial Assembly of Modular Glucosides via Carboxylesterases Regulates C. elegans Starvation Survival. Journal Of The American Chemical Society 2021, 143: 14676-14683. PMID: 34460264, PMCID: PMC8594405, DOI: 10.1021/jacs.1c05908.Peer-Reviewed Original ResearchConceptsStarvation conditionsCombinatorial assemblyPremier model systemRelated nematode speciesModel organismsStarvation survivalClose homologueGenome editingBiosynthetic roleNematode speciesBiological functionsComparative metabolomicsDeletion resultsAmino acidsFirst insightModel systemMetabolite libraryLipid metabolismAdult animalsAssemblyCRISPRBiosynthesisHomologuesDularOrganisms
2020
A neurotransmitter produced by gut bacteria modulates host sensory behaviour
O’Donnell M, Fox B, Chao P, Schroeder F, Sengupta P. A neurotransmitter produced by gut bacteria modulates host sensory behaviour. Nature 2020, 583: 415-420. PMID: 32555456, PMCID: PMC7853625, DOI: 10.1038/s41586-020-2395-5.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAvoidance LearningCaenorhabditis elegansCaenorhabditis elegans ProteinsFeeding BehaviorGastrointestinal MicrobiomeIntestinesMetabolomicsMutationNeurotransmitter AgentsOctanolsOctopamineProvidenciaReceptors, Biogenic AmineReceptors, G-Protein-CoupledSensory Receptor CellsSmellTyramineTyrosine DecarboxylaseConceptsTyramine biosynthesisFood choice assaysASH nociceptive neuronsDiverse organismsCaenorhabditis elegansMutualistic relationshipComplex communitiesChoice assaysMechanistic basisHost behaviourOlfactory responsesPhysiological relevanceOctopamine receptorsGut bacteriaElegansBioactive neurotransmittersBacteriaBiosynthesisHost controlGenesNervous system activitySensory behaviorsOctopamineNociceptive neuronsProvidencia
2018
Thermosensation: Human Parasitic Nematodes Use Heat to Hunt Hosts
O’Donnell M, Khan M, Sengupta P. Thermosensation: Human Parasitic Nematodes Use Heat to Hunt Hosts. Current Biology 2018, 28: r795-r798. PMID: 30040942, DOI: 10.1016/j.cub.2018.05.082.Peer-Reviewed Original ResearchRictor/TORC2 mediates gut-to-brain signaling in the regulation of phenotypic plasticity in C. elegans
O’Donnell M, Chao P, Kammenga J, Sengupta P. Rictor/TORC2 mediates gut-to-brain signaling in the regulation of phenotypic plasticity in C. elegans. PLOS Genetics 2018, 14: e1007213. PMID: 29415022, PMCID: PMC5819832, DOI: 10.1371/journal.pgen.1007213.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAnimalsAnimals, Genetically ModifiedBrainCaenorhabditis elegansCaenorhabditis elegans ProteinsGene Expression Regulation, DevelopmentalIntestinal MucosaIntestinesMechanistic Target of Rapamycin Complex 2Neuronal PlasticityPhenotypeRapamycin-Insensitive Companion of mTOR ProteinSensory Receptor CellsSignal TransductionTemperatureConceptsQuantitative trait lociDauer larval stageTarget of rapamycinNematode C. elegansExternal cuesInsulin-like peptidesNeuronal functionDAF-7Phenotypic plasticityDaf-28Developmental decisionsC. elegansTrait lociCellular stressorsBacterial foodGenetic variationForaging behaviorRictor/Reproductive growthLarval developmentEnvironmental cuesNeuroendocrine gene expressionGene expressionLarval stagesFood signals
2015
Correction: Feeding state-dependent regulation of developmental plasticity via CaMKI and neuroendocrine signaling
Neal S, Takeishi A, O'Donnell M, Park J, Hong M, Butcher R, Kim K, Sengupta P. Correction: Feeding state-dependent regulation of developmental plasticity via CaMKI and neuroendocrine signaling. ELife 2015, 4: e11547. PMID: 26394001, PMCID: PMC4576173, DOI: 10.7554/elife.11547.Peer-Reviewed Original ResearchFeeding state-dependent regulation of developmental plasticity via CaMKI and neuroendocrine signaling
Neal S, Takeishi A, O'Donnell M, Park J, Hong M, Butcher R, Kim K, Sengupta P. Feeding state-dependent regulation of developmental plasticity via CaMKI and neuroendocrine signaling. ELife 2015, 4: e10110. PMID: 26335407, PMCID: PMC4558564, DOI: 10.7554/elife.10110.Peer-Reviewed Original ResearchConceptsNeuroendocrine signalingDevelopmental plasticityInsulin-like peptide genesDynamic subcellular localizationDauer decisionDauer formationILP genesDauer stageDevelopmental decisionsSubcellular localizationNutrient availabilityState-dependent regulationPeptide genesReproductive cycleUnknown mechanismCaMKICMK-1SignalingGenesSensory neuronsPlasticityExpressionAWCCaenorhabditisSmall neuronal networks
2013
Distinct functional domains of the Abelson tyrosine kinase control axon guidance responses to Netrin and Slit to regulate the assembly of neural circuits
O’Donnell M, Bashaw G. Distinct functional domains of the Abelson tyrosine kinase control axon guidance responses to Netrin and Slit to regulate the assembly of neural circuits. Development 2013, 140: 2724-2733. PMID: 23720041, PMCID: PMC3678342, DOI: 10.1242/dev.093831.Peer-Reviewed Original ResearchConceptsFunctional domainsC-terminal F-actinGuidance pathwayMidline axon crossingDistinct functional domainsAbelson tyrosine kinaseFunctional nervous systemKinase-dependent inhibitionAbl C-terminusGenetic screenMultifunctional kinaseMotor axonsNervous systemDistinct structural motifsNon-overlapping setsGuidance ligandsNeural circuitsSignaling cascadesC-terminusMidline attractionTyrosine kinaseF-actinAxon crossingAxon guidanceGuidance responsesSrc Inhibits Midline Axon Crossing Independent of Frazzled/Deleted in Colorectal Carcinoma (DCC) Receptor Tyrosine Phosphorylation
O'Donnell M, Bashaw G. Src Inhibits Midline Axon Crossing Independent of Frazzled/Deleted in Colorectal Carcinoma (DCC) Receptor Tyrosine Phosphorylation. Journal Of Neuroscience 2013, 33: 305-314. PMID: 23283343, PMCID: PMC3739878, DOI: 10.1523/jneurosci.2756-12.2013.Peer-Reviewed Original ResearchConceptsSrc kinaseMidline axonsTyrosine phosphorylationSrc family kinasesDrosophila embryonic CNSReceptor tyrosine phosphorylationCommissural axonsDrosophila orthologUnexpected functionFamily kinasesEmbryonic CNSDownstream effectorsMidline attractionNetrin receptor DCCKinaseNetrin familyNovel mechanismAttractive turningPhosphorylationEffectorsReceptor DCCOrthologsCommissural neuronsVertebratesFrazzled
2009
Axon Growth and Guidance: Receptor Regulation and Signal Transduction
O'Donnell M, Chance R, Bashaw G. Axon Growth and Guidance: Receptor Regulation and Signal Transduction. Annual Review Of Neuroscience 2009, 32: 383-412. PMID: 19400716, PMCID: PMC4765433, DOI: 10.1146/annurev.neuro.051508.135614.Peer-Reviewed Original ResearchConceptsNeural developmental disordersReceptor regulationGrowth cone cytoskeletonAxon growthGrowth cone guidanceSignal transductionGuidance receptorsPathway functionWiring specificityRegulated actionGuidance cuesNervous systemNeuronal receptorsRegulationReceptorsRecent advancesCytoskeletonTransductionConsiderable progressDevelopmental disordersGrowthTemporal distributionMechanismConnectivity patternsFamily
2006
Functional analysis of Sox8 during neural crest development in Xenopus
O'Donnell M, Hong C, Huang X, Delnicki R, Saint-Jeannet J. Functional analysis of Sox8 during neural crest development in Xenopus. Development 2006, 133: 3817-3826. PMID: 16943273, DOI: 10.1242/dev.02558.Peer-Reviewed Original ResearchConceptsNeural crest developmentNeural crest progenitorsNeural plate borderCrest developmentNeural crest cellsCrest cellsSOX8 expressionExpression domainsPlate borderCranial crest cellsTrunk neural crest cellsMorpholino-mediated knockdownNeural crest specificationNeural crest formationMid-gastrula stageSpecies-specific differencesSox proteinsProgenitor specificationSoxE proteinsCrest formationTranscription factorsChick orthologPharyngeal archesMultiple lineagesNeural plateKermit 2/XGIPC, an IGF1 receptor interacting protein, is required for IGF signaling in Xenopus eye development
Wu J, O'Donnell M, Gitler A, Klein P. Kermit 2/XGIPC, an IGF1 receptor interacting protein, is required for IGF signaling in Xenopus eye development. Development 2006, 133: 3651-3660. PMID: 16914488, DOI: 10.1242/dev.02547.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsCell ProliferationCell SurvivalEyeGene Expression Regulation, DevelopmentalImmunoblottingImmunoprecipitationIn Situ HybridizationIn Situ Nick-End LabelingInsulin-Like Growth Factor INerve Tissue ProteinsPhenotypeProtein BindingProto-Oncogene Proteins c-aktReceptor, IGF Type 1Reverse Transcriptase Polymerase Chain ReactionSignal TransductionXenopusXenopus ProteinsConceptsXenopus eye developmentEye developmentPDZ domain-containing proteinsHigh amino acid similarityActive PI3-kinaseAmino acid similarityIGF1 receptorFunction phenotypesMembrane proteinsPI3-kinaseEctodermal explantsEmbryonic developmentXenopus embryosDistinct functionsEye formationNeural crestNovel componentEndogenous functionsGIPCAkt activationVivo lossPhysiological significanceIGF pathwayProteinFunction analysis
2005
The doublesex-related gene, XDmrt4, is required for neurogenesis in the olfactory system
Huang X, Hong C, O'Donnell M, Saint-Jeannet J. The doublesex-related gene, XDmrt4, is required for neurogenesis in the olfactory system. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 11349-11354. PMID: 16061812, PMCID: PMC1183594, DOI: 10.1073/pnas.0505106102.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceBasic Helix-Loop-Helix Transcription FactorsCloning, MolecularDNA PrimersGene Expression RegulationIn Situ HybridizationMolecular Sequence DataMorphogenesisNerve Tissue ProteinsOlfactory PathwaysOligonucleotide ProbesReverse Transcriptase Polymerase Chain ReactionSequence Analysis, DNATranscription FactorsXenopusXenopus ProteinsConceptsDmrt genesTranscription factorsHelix transcription factorAnterior neural ridgeNeural cell adhesion molecule expressionAnterior neural plateCell adhesion molecule expressionAdhesion molecule expressionInhibitory mutantAnimal explantsMorpholino oligonucleotideDevelopmental processesNeural inducersNeural plateExpression patternsFunctional analysisNeural ridgePlacodal markersSimilar phenotypeNeuronal differentiationMolecule expressionImportant regulatorSpecific disruptionOlfactory epitheliumLarge family