Combinatorial Assembly of Modular Glucosides via Carboxylesterases Regulates C. elegans Starvation Survival
Wrobel C, Yu J, Rodrigues P, Ludewig A, Curtis B, Cohen S, Fox B, O’Donnell M, Sternberg P, Schroeder F. Combinatorial Assembly of Modular Glucosides via Carboxylesterases Regulates C. elegans Starvation Survival. Journal Of The American Chemical Society 2021, 143: 14676-14683. PMID: 34460264, PMCID: PMC8594405, DOI: 10.1021/jacs.1c05908.Peer-Reviewed Original ResearchMeSH KeywordsAcylationAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsCarboxylic Ester HydrolasesGlucosidesMetabolomicsOrtho-AminobenzoatesStarvationConceptsStarvation conditionsCombinatorial assemblyPremier model systemRelated nematode speciesModel organismsStarvation survivalClose homologueGenome editingBiosynthetic roleNematode speciesBiological functionsComparative metabolomicsDeletion resultsAmino acidsFirst insightModel systemMetabolite libraryLipid metabolismAdult animalsAssemblyCRISPRBiosynthesisHomologuesDularOrganisms