2021
Combinatorial Assembly of Modular Glucosides via Carboxylesterases Regulates C. elegans Starvation Survival
Wrobel C, Yu J, Rodrigues P, Ludewig A, Curtis B, Cohen S, Fox B, O’Donnell M, Sternberg P, Schroeder F. Combinatorial Assembly of Modular Glucosides via Carboxylesterases Regulates C. elegans Starvation Survival. Journal Of The American Chemical Society 2021, 143: 14676-14683. PMID: 34460264, PMCID: PMC8594405, DOI: 10.1021/jacs.1c05908.Peer-Reviewed Original ResearchConceptsStarvation conditionsCombinatorial assemblyPremier model systemRelated nematode speciesModel organismsStarvation survivalClose homologueGenome editingBiosynthetic roleNematode speciesBiological functionsComparative metabolomicsDeletion resultsAmino acidsFirst insightModel systemMetabolite libraryLipid metabolismAdult animalsAssemblyCRISPRBiosynthesisHomologuesDularOrganisms
2020
A neurotransmitter produced by gut bacteria modulates host sensory behaviour
O’Donnell M, Fox B, Chao P, Schroeder F, Sengupta P. A neurotransmitter produced by gut bacteria modulates host sensory behaviour. Nature 2020, 583: 415-420. PMID: 32555456, PMCID: PMC7853625, DOI: 10.1038/s41586-020-2395-5.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAvoidance LearningCaenorhabditis elegansCaenorhabditis elegans ProteinsFeeding BehaviorGastrointestinal MicrobiomeIntestinesMetabolomicsMutationNeurotransmitter AgentsOctanolsOctopamineProvidenciaReceptors, Biogenic AmineReceptors, G-Protein-CoupledSensory Receptor CellsSmellTyramineTyrosine DecarboxylaseConceptsTyramine biosynthesisFood choice assaysASH nociceptive neuronsDiverse organismsCaenorhabditis elegansMutualistic relationshipComplex communitiesChoice assaysMechanistic basisHost behaviourOlfactory responsesPhysiological relevanceOctopamine receptorsGut bacteriaElegansBioactive neurotransmittersBacteriaBiosynthesisHost controlGenesNervous system activitySensory behaviorsOctopamineNociceptive neuronsProvidencia