Distinct functional domains of the Abelson tyrosine kinase control axon guidance responses to Netrin and Slit to regulate the assembly of neural circuits
O’Donnell M, Bashaw G. Distinct functional domains of the Abelson tyrosine kinase control axon guidance responses to Netrin and Slit to regulate the assembly of neural circuits. Development 2013, 140: 2724-2733. PMID: 23720041, PMCID: PMC3678342, DOI: 10.1242/dev.093831.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsDrosophilaDrosophila ProteinsNerve Tissue ProteinsNetrin ReceptorsProtein BindingProtein-Tyrosine KinasesReceptors, Cell SurfaceConceptsFunctional domainsC-terminal F-actinGuidance pathwayMidline axon crossingDistinct functional domainsAbelson tyrosine kinaseFunctional nervous systemKinase-dependent inhibitionAbl C-terminusGenetic screenMultifunctional kinaseMotor axonsNervous systemDistinct structural motifsNon-overlapping setsGuidance ligandsNeural circuitsSignaling cascadesC-terminusMidline attractionTyrosine kinaseF-actinAxon crossingAxon guidanceGuidance responsesSrc Inhibits Midline Axon Crossing Independent of Frazzled/Deleted in Colorectal Carcinoma (DCC) Receptor Tyrosine Phosphorylation
O'Donnell M, Bashaw G. Src Inhibits Midline Axon Crossing Independent of Frazzled/Deleted in Colorectal Carcinoma (DCC) Receptor Tyrosine Phosphorylation. Journal Of Neuroscience 2013, 33: 305-314. PMID: 23283343, PMCID: PMC3739878, DOI: 10.1523/jneurosci.2756-12.2013.Peer-Reviewed Original ResearchConceptsSrc kinaseMidline axonsTyrosine phosphorylationSrc family kinasesDrosophila embryonic CNSReceptor tyrosine phosphorylationCommissural axonsDrosophila orthologUnexpected functionFamily kinasesEmbryonic CNSDownstream effectorsMidline attractionNetrin receptor DCCKinaseNetrin familyNovel mechanismAttractive turningPhosphorylationEffectorsReceptor DCCOrthologsCommissural neuronsVertebratesFrazzled