2013
Src Inhibits Midline Axon Crossing Independent of Frazzled/Deleted in Colorectal Carcinoma (DCC) Receptor Tyrosine Phosphorylation
O'Donnell M, Bashaw G. Src Inhibits Midline Axon Crossing Independent of Frazzled/Deleted in Colorectal Carcinoma (DCC) Receptor Tyrosine Phosphorylation. Journal Of Neuroscience 2013, 33: 305-314. PMID: 23283343, PMCID: PMC3739878, DOI: 10.1523/jneurosci.2756-12.2013.Peer-Reviewed Original ResearchConceptsSrc kinaseMidline axonsTyrosine phosphorylationSrc family kinasesDrosophila embryonic CNSReceptor tyrosine phosphorylationCommissural axonsDrosophila orthologUnexpected functionFamily kinasesEmbryonic CNSDownstream effectorsMidline attractionNetrin receptor DCCKinaseNetrin familyNovel mechanismAttractive turningPhosphorylationEffectorsReceptor DCCOrthologsCommissural neuronsVertebratesFrazzled
2009
Axon Growth and Guidance: Receptor Regulation and Signal Transduction
O'Donnell M, Chance R, Bashaw G. Axon Growth and Guidance: Receptor Regulation and Signal Transduction. Annual Review Of Neuroscience 2009, 32: 383-412. PMID: 19400716, PMCID: PMC4765433, DOI: 10.1146/annurev.neuro.051508.135614.Peer-Reviewed Original ResearchConceptsNeural developmental disordersReceptor regulationGrowth cone cytoskeletonAxon growthGrowth cone guidanceSignal transductionGuidance receptorsPathway functionWiring specificityRegulated actionGuidance cuesNervous systemNeuronal receptorsRegulationReceptorsRecent advancesCytoskeletonTransductionConsiderable progressDevelopmental disordersGrowthTemporal distributionMechanismConnectivity patternsFamily